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Fertility requires the faithful proliferation of germ cells and their differentiation into gametes. Controlling these cellular states demands precise timing and expression of gene networks. Nucleic acid binding proteins (NBPs) play critical roles in gene expression networks that influence germ cell development. There has, however, been no functional analysis of the entire NBP repertoire in control
Achievement of sustainability goals is an epic task for developing economies that still strive to fulfil their basic needs. The availability of limited resources in the developing world vis-à-vis the ever-increasing demand poses further challenges to developing economies willing to transition into circular economies. Reverse logistics (RL) can facilitate this transition towards a circular economy
BACKGROUND: Compared to ischemic stroke, sex differences in patient outcomes following intracerebral hemorrhage (ICH) are underreported. We aimed to determine sex differences in mortality and functional outcomes in a large, unselected Swedish cohort.METHODS: In this observational study, data on 22,789 patients with spontaneous ICH registered in the Swedish Stroke Register between 2012 and 2019 wer
AIM: To describe sociodemographic disparities in temporal trends of incidence and age distributions of first registered osteoarthritis (OA) diagnosis in southern Sweden.METHODS: We identified all Skåne residents aged 35+ who had lived in the region at any point during the period 2006-2019 with no previous OA diagnosis (ICD-10 codes M15-M19) for 8 years prior to inclusion in the study (n = 849,061)
IMPORTANCE: Perforated colonic diverticulitis usually requires surgical resection, which is associated with significant morbidity. Cohort studies have suggested that laparoscopic lavage may treat perforated diverticulitis with less morbidity than resection procedures. OBJECTIVE: To compare the outcomes from laparoscopic lavage with those for colon resection for perforated diverticulitis. DESIGN, S
Amyloid fibrils are highly insoluble in neutral aqueous media of regular ionic strengths making solubilization a difficult task that normally calls for extremely harsh treatment. This is among the reasons for the routine employment of synthetic proteins in amyloid research, where the amylogenic components are needed. Here we describe a process for solubilizing amyloid in pure water that we adopted
Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid within arteries of the cerebral cortex and leptomeninges. This condition is age related, especially prevalent in Alzheimer's disease (AD) and the main feature of certain hereditary disorders. The vascular smooth muscle cells (VSMC) appear to play a vital role in the development of CAA and have been found to produce t
This paper aims to explore how four Bolivian small and medium-sized enterprises’ business has overcome the gaps in reliance on traditional small and medium-sized enterprises’ business models, i.e., to extract and sell raw unrefined natural resources in a local area, and instead make productive use of innovation inputs (technology, higher-educated people) by innovating their business models. We wer
The broad goal of this thesis is to develop a deeper mathematical understanding of the processes at work in the neuronal network of a brain by rigorously examining very fundamental elements of the processes involved. Paper I considers the flow of discrete signals on a graph and Paper II the complexity arising from the interplay of simple units. The concrete probabilistic investigations of such mod
This chapter analyzes five cases in which the Turkish Constitutional Court banned political parties, advocating for equal citizenship rights for the Kurdish people, based on their alleged violation of the law on political parties, which prohibits claims of the existence of minorities. The chapter aims to explore the conceptualization of minority rights within the juridico-political realm of Turkey
The Long-Term Global Goal (LTGG) is the focal point for addressing future climate change. This paper explores a specific institutional context: the Structured Expert Dialogue (SED) of the UN Framework Convention on Climate Change (UNFCCC). Set up as a platform for interaction between experts and UN negotiators, the SED is a site where scientific information about the LTGG and net-zero was translat
The Øresund Fixed Link is a 15,9 km road and railway connection between the southerly Swedish city of Malmö and its neighbor across the Øresund strait, Copenhagen, in Denmark. The link, which opened in 2000, consists of an elevated bridge, including a high stay cable bridge, an artificial island, as well as a submerged tunnel. The operators of the link, Øresundsbron Consortium, have recently, as p
