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Introduction: Primary progressive aphasia (PPA) is divided into three prototypical subtypes that are all characterized by their single core symptom of aphasia. Although later in their course, other cognitive, behavioral, and motor domains may become involved, little is known about the progression profile of each subtype relative to the other subtypes. Methods: In this longitudinal retrospective co
Acute dyspnea with underlying congestion is a leading cause of emergency department (ED) visits with high rates of hospitalization. Adrenomedullin is a vasoactive neuropeptide hormone secreted by the endothelium that mediates vasodilation and maintains vascular integrity. Plasma levels of biologically active adrenomedullin (bio-ADM) predict septic shock and vasopressor need in critically ill patie
AIMS: This study aimed to investigate the association between the 'Shrunken pore syndrome' (SPS) and risk of death, 30 day rehospitalization, and health-related quality of life (QoL) in heart failure (HF) patients. SPS is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatin C /eGFRcreatinine ratio.METHODS AND RESULTS: A total of 373 p
A bis(18-crown-6) Tröger's base receptor and 4-substituted hepta-1,7-diyl bisammonium salt ligands have been used as a model system to study the interactions between non-polar side chains of peptides and an aromatic cavity of a protein. NMR titrations and NOESY/ROESY NMR spectroscopy were used to analyze the discrimination of the ligands by the receptor based on the substituent of the ligand, both
Haemophilia A and B are rare congenital, recessive X-linked disorders caused by lack or deficiency of clotting factor VIII (FVIII) or IX (FIX), respectively. The severity of the disease depends on the reduction of levels of FVIII or FIX, which are determined by the type of the causative mutation in the genes encoding the factors (F8 and F9, respectively). The hallmark clinical characteristic, espe
Ozonation is an established technique used to reduce the discharge of organic micropollutants into the aquatic environment, but the possibility of predicting the ozone demand for different wastewater matrices is still limited, especially in the presence of suspended solids (SS). A new tool for the prediction of the removal of organic micropollutants with ozone, based on dissolved and particulate m
We have obtained the X-ray crystal structure of the galectin-8 N-terminal domain (galectin-8N) with a previously reported quinoline–galactoside ligand at a resolution of 1.6 Å. Based on this X-ray structure, a collection of galactosides derivatised at O3 with triazole, benzimidazole, benzothiazole, and benzoxazole moieties were designed and synthesised. This led to the discovery of a 3-O-(N-methyl
Purpose: The discipline's most common uses for literature reviews—identifying gaps, developing research agendas, and categorizing the literature—too often fail to challenge, change or advance theoretical perspectives. The authors offer guidance to theorization through literature reviews. The key to theory advancement is consistency between the state of theory and the chosen review type. Design/met
Many glaciated valleys in Scotland contain distinctive, closely spaced ridges and mounds, which have been termed ‘hummocky moraine’. The ridges and mounds are widely interpreted as ice-marginal moraines, constructed during active retreat of mainly temperate glaciers. However, hummocky terrain can form by various processes in glacial environments, and it may relate to a range of contrasting glaciod
COL1-related overlap disorder is a condition, which is not yet considered as part of the 2017 EDS classification. However, it should be investigated as an alternative diagnosis for any patient with hypermobile EDS. This could allow providing appropriate genetic counseling.
Proof load testing may be performed to confirm the reliability of the bridge for an existing classification or to prove the reliability for a higher classification.In this paper, a probabilistic decision analysisapproach is applied to the scenario for the evaluation of target proof load in the situation where information on the bridge resistance model is lacking. In this case, the resistance model
The invasive Spanish slug (Arion vulgaris) is an important pest species in agriculture and horticulture in Europe. In the last decades it has spread across the continent where it outcompetes native slug and snail species, thus posing a threat for biodiversity. A popular anecdote suggests to promote Roman snails (Helix pomatia) in gardens because they are able to control A. vulgaris. We examined a
Cardiovascular disease (CVD) is one of the leading causes of death worldwide. Atherosclerosis, a chronic pathology directly related to the circulatory system, develops due to an interplay between several molecular events. Atherosclerotic plaque build-up can lead to a reduction in arterial blood flow and finally, myocardial infarction (MI). To prevent or slow down of the CVD progression, it is impo
BACKGROUND: Autonomous cortisol secretion in patients with adrenal incidentalomas is associated with increased mortality, but detailed information about the risk associated with specific levels of autonomous cortisol secretion is not available.OBJECTIVE: To measure the association between mortality and levels of autonomous cortisol secretion in patients with adrenal incidentalomas.DESIGN: Retrospe
New digitally enabled modes of food provisioning are being developed. The aim of this paper is to examine, empirically illustrate, and conceptualize how and under what conditions these digital food platforms become routinized and what this means for the enabling of sustainable food consumption.Drawing on an ethnographically inspired study of three digital food provision platforms - i.e. meal box s
Audio description (AD) provides access to audiovisual materials for people with visual impairments and blindness (BVI) and offers a richer and more detailed understanding and experience. The cognitive approach to AD concerns perceptual, cognitive and meaning-making processes underlying production and reception of AD. By meaning-making, we mean multimodal textual and contextual processing, understaAudio description (AD) provides access to audiovisual materials for people with visual impairments and blindness (BVI) and offers a richer and more detailed understanding and experience. The cognitive approach to AD concerns perceptual, cognitive and meaning-making processes underlying production and reception of AD. By meaning-making, we mean multimodal textual and contextual processing, understa
