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Leaders of work package 7: Jan Nilsson and Olle Melander This work package focuses on diabetes-driven cardiovascular disease (CVD). The mild age-related diabetes (MARD) cluster, together with the mild obesity-related diabetes (MOD) and the severe insulin-resistant diabetes (SIRD) has the highest risk of developing CVD.Central to the studies in this work package are a number of well-characterised c

https://www.ludc.lu.se/ludc-irc/mild-age-related-diabetes-mard-mechanisms-and-pathways - 2026-05-29

News from the Innovation Office.

https://www.ludc.lu.se/newsletters - 2026-05-29

Leaders of work package 5: Ola Hansson and Eva Degerman SIRD is a novel form of diabetes representing the most insulin resistant (both hepatic and peripheral) form, with most features of the metabolic syndrome but also hepatic steatosis. In this work-package we explore mechanisms and pathways relevant to insulin resistance in various organs and tissues, such as liver, adipose tissue, kidney, skele

https://www.ludc.lu.se/ludc-irc/severe-insulin-resistant-diabetes-sird-mechanisms-and-pathways - 2026-05-29

Leaders of work package 1: Emma Ahlqvist and Dmytro Kryvokhyzha One of the main resources to the LUDC-IRC is the access to large well-phenotyped cohorts, which can be linked to information from the public health care system. Central to the LUDC-IRC work is the exploitation of the more refined diabetes classification, which will help us more systematically search for pathogenic mechanisms underlyin

https://www.ludc.lu.se/ludc-irc/data-harmonisation-and-integration - 2026-05-29

Leaders of work package 8: Gustav Smith and Andreas Edsfeldt LUDC-IRC takes advantage of the accumulated expertise of investigators and resources available to conduct recall trials based on pathogenetically relevant biomarkers or genotypes or based upon subtype of diabetes.Work package 8 has access to  unique, large-scale clinical cohorts that include patients with diabetes and diabetes-associated

https://www.ludc.lu.se/ludc-irc/clinical-validation-randomised-trials-and-interventions - 2026-05-29

Head: Ola Hansson Our research interest is to understand how genetic variation influences skeletal muscle function and whole-body metabolism. We use translational approaches and regularly conduct focused intervention studies in humans, including skeletal muscle biopsies. From the biopsies, muscle stem cells (satellite cells) are isolated and later used for preclinical measurements. In our projects

https://www.ludc.lu.se/research/ola-hansson - 2026-05-29

Albert Salehi’s group The etiology of metabolic syndrome and type 2 diabetes is complex and involves the interaction between both genetic and environmental factors including nutritional state with consequent metabolic signals. There are currently no clinical treatments to prevent, reverse, or efficiently cure the progression of rapid beta-cell demise or insulin resistance in diabetes-prone individ

https://www.ludc.lu.se/research/islet-cell-physiology - 2026-05-29

Head: Karin Stenkula My research group is focused on experimental cell biology research within the diabetes and obesity field. The overall purpose of our research is to explore both normal adipose cell function and the cellular mechanisms causing impaired glucose- and lipid metabolism associated with insulin resistance and type 2 diabetes. At a single cell level, we have shown that the GLUT4 trans

https://www.ludc.lu.se/glucose-transport-and-protein-trafficking - 2026-05-29

Daniel Agardh’s group Our researchThe overall purpose of our research is to uncover the genetic and environmental etiology of three autoimmune diseases – celiac disease, type 1 diabetes, and autoimmune thyroiditis. Specific autoantibody markers are used to predict the clinical onset of these three lifelong autoimmune diseases. Longitudinal studies of children at increased risk allow studies of the

https://www.ludc.lu.se/research/celiac-disease-and-diabetes-unit - 2026-05-29

Head: Karin Berger   According to WHO, improving nutrition is the single most important contributor to reduce the burden of diabetes in Europe. Polyphenols are compounds with anti-oxidative effect providing taste and color in plant-based food. In the last decade, polyphenol-rich foods have received increased interest from researchers and food industry. The main reason for this interest is the reco

https://www.ludc.lu.se/research-0/molecular-nutrition-group - 2026-05-29

Leaders for work package 6: Nils Wierup, Cecilia Holm, and Olga Göransson The mild obesity-related diabetes (MOD) cluster includes the most obese but not the most insulin resistant individuals. Obesity is a common risk factor for type 2 diabetes and its complications. This work package explores the differences between metabolically healthy and unhealthy obesity and focuses on elucidating the mecha

https://www.ludc.lu.se/ludc-irc/mild-obesity-related-diabetes-mod-mechanisms-and-pathways - 2026-05-29

Leaders for work package 4: Lena Eliasson and Enming Zhang (Enming Zhang acts as Erik Renström’s deputy) The severe insulin-deficient diabetes (SIDD) subgroup is characterised by non-autoimmune impaired insulin secretion and was previously hidden in the type 2 diabetes group. In this work package we aim to examine underlying mechanisms of to find possible pharmacological targets to be used in pers

https://www.ludc.lu.se/ludc-irc/severe-insulin-deficient-diabetes-mechanisms-pathways - 2026-05-29

Leaders for work package 3: Luis Sarmiento-Pérez, Åke Lernmark, and Annelie Carlsson Investigators at the LUDC-IRC have a long track record of conducting studies aimed at early prediction and prevention of type 1 diabetes (in our new sub classification also referred as SAID – severe autoimmune diabetes) and its complications in children. Efforts include the initiation and maintenance of well-chara

https://www.ludc.lu.se/ludc-irc/severe-autoimmune-diabetes-said-mechanisms-and-pathways - 2026-05-29

The LUDC Bioinformatics Unit provides researchers, students, and technical personnel affiliated with LUDC with bioinformatics, biostatistics, and computational support. The unit also offers access to a high-performance computing environment. For questions or support requirements, please see contact details on this page.Link to webpage with more information about support and contact detailsBioinfor

https://www.ludc.lu.se/resources/ludc-bioinformatics-unit - 2026-05-29

Our team is here to help you with bioinformatics, biostatistics, and computational support. Do you have short and specific questions for our experts? Our preferred means of communication is our dedicated Slack channel. Anyone with a Faculty of Medicine email address (@med.lu.se) can join this channel. You can also email your questions directly to specific members of the Bioinformatics Unit.Link to

https://www.ludc.lu.se/resources/ludc-bioinformatics-unit-contact - 2026-05-29

Do you have an idea or research results that you would like to pursue further? Students and researchers at Lund University can discuss ideas with an innovation developer at LU Innovation. One way for you to ensure that your research findings bring value outside of the research environment is to transform them into a new service, product, or method. If you believe that your research findings could

https://www.ludc.lu.se/resources/innovation-support - 2026-05-29

Ola Hansson’s group Our researchOur research unit is interested in learning how genetic variation influences skeletal muscle function and whole-body metabolism.We use translational approaches and regularly conduct focused intervention studies in humans. These studies involve taking skeletal muscle biopsies. From the biopsies, muscle stem cells (satellite cells) are isolated and later used for prec

https://www.ludc.lu.se/translational-muscle-research-unit - 2026-05-29

Corrado Cilio’s group Our researchThere is still no cure for type 1 diabetes (T1D), a disease which is associated with severe chronic complications. Obtaining a comprehensive understanding of the triggers and mechanisms responsible for beta cell loss in T1D is crucial for establishing therapeutic approaches that can either slow down or prevent the disease.Our research focuses on understanding how

https://www.ludc.lu.se/research/diabetes-immunovirology - 2026-05-29

Allan Vaag’s group Our researchOur translational research strategy integrates multiple complementary research fields and innovative technologies to address key questions in the fields of integrative physiology, for example ex vivo multi-omics, muscle and adipose tissue biology, genetics, epigenetics, epidemiology, register research, and clinical trials.Our team and collaborators take advantage of

https://www.ludc.lu.se/research/translational-diabetes-research - 2026-05-29

The Flow Cytometry Core Facility at LUDC provides instrumentation and technical assistance to perform flow cytometric analysis and operator-based cell sorting service to all Lund University scientists. Scientists from other universities and the industry can also use the equipment. The LUDC Flow Cytometry Core Facility at LUDC is a flow cytometry facility located at Clinical Research Centre in Malm

https://www.ludc.lu.se/resources/flow-cytometry-core-facility-ludc - 2026-05-29