Topical negative pressure (TNP) treatment is a commonly used technique in the hospital care of acute or postoperative large, open wounds. In recent years the method has also been used to promote healing of so-called hard-to-heal ulcers, e.g. pressure ulcers, various leg ulcers, and diabetic foot ulcers. The SBU enquiry service has summarized the scientific literature on the clinical effects of TNP

Background: Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mitogenic and angiogenic factor, which is expressed at an increased level in human prostate tumours and is associated with a poor prognosis. We studied the effect of FGF8b on tumour

Isla de los Estados (54A degrees 45'S, 63A degrees 10'aEuro"64A degrees 46'W) lies east of the main island of Tierra del Fuego and is the southeastern-most point in Argentina. Because of its geographic position near the latitudes of the Southern Hemisphere Westerlies and the strong influence of the Antarctic Circumpolar Current (ACC), the area is suitable for paleoecological and paleoclimate resea

Many commercial dye preparations are cocktails of active dyes and various by-products that are recalcitrant to biological degradation and end up in significant amounts in the effluent after the dyeing process. Conventional wastewater treatment processes are not able to degrade such compounds and detoxify the effluent, thus alternative treatments should be developed. In our work we suggest to use p

Structural equilibrium properties of transient networks formed by microemulsion droplets and ABA triblock copolymers in solution have been studied by Monte Carlo simulation. The droplets were represented by soft spheres and the polymers by junctions connected by harmonic bonds with an angular potential regulating the intrinsic chain stiffness. The interaction parameters were selected such that the

In this paper we introduce a new algorithm for seismic imaging based on the flow out of Gaussian wave packets. We follow the standard strategy of decomposing data into wave packets and flowing them out along rays to approximate the downward wavefield extrapolation, and finally applying an imaging condition. We revisit each computational step to gain efficiency. Furthermore, we develop procedure fo

MicroRNAs have emerged as important regulators of smooth muscle phenotype and may play important roles in pathogenesis of various smooth muscle related disease states. The aim of this study was to investigate the role of miRNAs for urinary bladder function. We used an inducible and smooth muscle specific Dicer knockout (KO) mouse which resulted in significantly reduced levels of miRNAs, including

In models of anomaly-mediated supersymmetry breaking (AMSB), the lightest chargino is predicted to have a lifetime long enough to be detected in collider experiments. This letter explores AMSB scenarios in pp collisions at root s = 7 TeV by attempting to identify decaying charginos which result in tracks that appear to have few associated hits in the outer region of the tracking system. The search

Background: The complexity and dynamical nature of community interactions make modelling a useful tool for understanding how communities develop over time and how they respond to external perturbations. Large community-evolution models (LCEMs) are particularly promising, since they can address both ecological and evolutionary questions, and can give rise to richly structured and diverse model comm

Objective To investigate whether the risk allele for systemic lupus erythematosus (SLE) in the signal transducer and activator of transcription factor 4 (STAT4) gene, defined by the single nucleotide polymorphism (SNP) rs10181656(G), is associated with vascular events and/or presence of prothrombotic anti-phospholipid antibodies (aPL) in patients with SLE. Methods Two independent groups of unrelat

Although no common genetic defect has been described in chronic lymphocytic leukemia (CLL), recurrent genomic aberrations (i.e. deletions of chromosome 11q, 13q, 17p and trisomy 12) are important for prognostication. Deletion of 13q as single aberration is associated with the best prognosis, whereas del(11q) and del(17p) predict a poor outcome. Recent development of high-resolution genomic techniq

For vehicles using grid power to charge the battery, traction circuit components are not engaged during the charging time, so there is a possibility to use them in the charger circuit to have an onboard integrated charger. The battery charger can be galvanically isolated or nonisolated from the grid. Different examples of isolated or nonisolated integrated chargers are reviewed and explained. More

Normally dye molecules are adsorbed onto the nanocrystal (NC) surface in dye-NC mixed solution, but it is very unlikely that all dye molecules present in the solution will be attached to NCs. The distribution of dye molecules on the NC surface is an important factor to take into account while investigating the quenching of NC emission via energy transfer to adsorbed dye molecules. Here, we analyse

The human host-defense peptide LL-37 not only displays antimicrobial activity but also immune modulating properties that trigger intracellular signaling events in host cells. Since the cytolytic activity of high LL-37 concentrations affects cell viability, the function of LL-37 requires tight regulation. Eukaryotic cells therefore benefit from protective measures to prevent harmful effects of LL-3

Background: The aim of this study is to analyze longitudinally, based on four measurements at intervals of eight years, the annual effect of age group and birth cohort on regular exercise in the Swedish population from 1980-1981 to 2004-2005. Methods: We followed a randomly drawn subsample of individuals aged 16-63 years, interviewed by professional interviewers, from the Swedish Annual Level of L

Several zooplankton species are susceptible to ultraviolet radiation (UV), suggesting that UV may shape zooplankton community composition. Little is known, however, about the quantitative effects of long-term UV exposure in relation to biological processes. Therefore, we studied effects of UV on behaviour, population dynamics and reproduction of several zooplankton taxa. We identified different st