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Background Prostate cancer is one of the leading causes of cancer related deaths. For diagnosis, predicting the outcome of the disease, and for assessing potential new biomarkers, pathologists and researchers routinely analyze histological samples. Morphological and molecular information may be integrated by aligning microscopic histological images in a multiplex fashion. This process is usually

Recension av Magnus Alkarp, Fyra dagar i april: påskkravallerna i april 1943.

Acidogenic fermentation of wastewater can serve as a first step in a process for mixed culture production of polyhydroxyalkanoates (PHA) since the produced volatile fatty acids (VFA) are preferred substrates for PHA production. Acidogenic fermentation of industrial wastewaters (cheese whey permeate and three pulp and paper mill effluents) was evaluated in batch and continuous experiments. From the

Objective To compare drug survival on adalimumab, etanercept and infliximab in patients with rheumatoid arthritis (RA). Methods Patients with RA (n=9139; 76% women; mean age 56 years) starting their first tumour necrosis factor (TNF) inhibitor between 2003 and 2011 were identified in the Swedish Biologics Register (ARTIS). Data were collected through 31 December 2011. Drug survival over up to 5 ye

Also known as access block, shortage of inpatient beds is a common cause of emergency department (ED) boarding and overcrowding, which are both associated with impaired quality of care. Recent studies have suggested that access block not simply causes boarding in EDs, but may also result in that patients are less likely to be admitted to the hospital from the ED. The present study's aim was to inv

Twenty-five public supply wells throughout the hydrogeologically diverse region of Scania, Southern Sweden are subjected to environmental tracer analysis (3H–3He, 4He, CFCs, SF6 and for one well only also 85Kr and 39Ar) to study well and aquifer vulnerability and evaluate possibilities of groundwater age distribution assessment. We find CFC and SF6 concentrations well above solubility equilibrium

We examine how the generation and propagation of high-order harmonics in a partly ionized gas medium affect their strength and synchronization. The temporal properties of the resulting attosecond pulses generated in long gas targets can be significantly influenced by macroscopic effects, in particular by the intensity in the medium and the degree of ionization which control the dispersion. Under s

We add the Wess-Zumino-Witten term to the N = 3 massive nonlinear sigma model and study the leading logarithms in the anomalous sector. We obtain the leading logarithms to six loops for pi(0) -> gamma*gamma* and to five loops for y*pi pi pi. In addition we extend the earlier work on the mass and decay constant to six loops and the vector form factor to five loops. We present numerical results for

The soil salinity distribution and solute transport properties of three different soil types were investigated and compared within a project area in northeastern Egypt. For this purpose, dye tracer experiments and salinity sampling were carried out. The resulting salinity maps showed that the soil salinity in the cultivated western site of the project area is 8-10 times higher than that in the cul

Popular Abstract in Swedish Allergiska besvär från luftvägarna utgör ett stort och växande folkhälsoproblem. Det finns idag ingen bot mot dessa sjukdomar och de kan, om de inte behandlas, utgöra ett betydande hinder i vardagen. Även om dagens mediciner i de allra flesta fall kuperar symtomen väl, vet man, att många patienter är odiagnostiserade eller saknar behandling trots diagnos. Målet med behAllergic diseases, which constitute a global health problem, have been defined as one of the epidemics of the twenty-first century. Since there are no cures for allergic diseases today, the goal of treatment is to get the disease under control so that the patient can live a normal life with optimal chances of development. Patient-reported outcomes for control assessment have been a focus of attent

Serine/arginine (SR) protein-specific kinase (SRPK), a family of cell cycle-regulated protein kinases, phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing. However, the physiologic roles of this event in cell cycle are incompletely understood. Here, we show that SRPK2 binds and phosphorylates acinus, an SR protein essential for RNA splicing, and redist

Background: Transanal endorectal one-stage pull-through (TERPT) procedure in children with Hirschsprung’s disease (HD) is frequently used worldwide. In order to give the families realistic expectations and to plan the medical care for the years after TERPT, the long term outcome is of great importance. Aim: To collect information on the long term outcome reported after one stage TERPT procedure fo

We propose a sender-specific blockmodel for network data which utilizes both the group membership and the identities of the vertices. This is accomplished by introducing the edge probabilities $(\theta_{i, v})$ for $1\le i\le c, 1\le v\le n$, where $i$ specifies the group membership of a sending vertex and $v$ specifies the identity of the receiving vertex. In addition, group membership is conside

Recension av Dennis E. Showalter & Harold C. Deutsch (red.), Om Tyskland segrat – 53 alternativa scenarier.

Attention deficit/hyperactivity disorder (ADHD) is characterized by inattention, impulsivity, and motor hyperactivity. Several lines of research support a crucial role for the dopamine transporter (DAT) gene in this psychiatric disease. Consistently, the most commonly prescribed medications in ADHD treatment are stimulant drugs, known to preferentially act on DAT. Recently, a knock-in mouse [DAT-c