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Early white matter pathology in the fornix of the limbic system in Huntington disease

Gabery S, Kwa JE, Cheong RY, Baldo B, Ferrari Bardile C, Tan B, McLean C, Georgiou-Karistianis N, Poudel GR, Halliday G, Pouladi MA and Petersén Å.  Acta Neuropathologica. 142(5): 791-806 (2021) doi: 10.1007/s00401-021-02362-8. Abstract Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. The typical motor symptoms have been a

https://www.huntington-research.lu.se/early-white-matter-pathology-fornix-limbic-system-huntington-disease - 2026-05-09

Ubiquitin specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1α

Hyrskyluoto A, Bruelle C, Lundh SH, Do HT, Kivinen J, Rappou E, Reijonen S, Waltimo T, Petersén Å, Lindholm D and Korhonen L.Human Molecular Genetics 23: 5928-5939 (2014)AbstractHuntington's disease (HD) is an autosomal inherited neurological disease caused by a CAG repeat expansion in the first exon of huntingtin gene encoding for the huntingtin protein (Htt). In HD there is an accumulation of in

https://www.huntington-research.lu.se/ubiquitin-specific-protease-14-reduces-cellular-aggregates-and-protects-against-mutant-huntingtin - 2026-05-09

Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice

Dickson E, Soylu-Kucharz R , Petersén Å and Björkqvist M. Mol Metab. 2022 Mar;57:101439. doi: 10.1016/j.molmet.2022.101439. Epub 2022 Jan 7. Abstract Objective In Huntington's disease (HD), the disease-causing huntingtin (HTT) protein is ubiquitously expressed and causes both central and peripheral pathology. In clinical HD, a higher body mass index has been associated with slower disease progress

https://www.huntington-research.lu.se/hypothalamic-expression-huntingtin-causes-distinct-metabolic-changes-huntingtons-disease-mice - 2026-05-09

IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model

Soylu-Kucharz R, Khoshnan A and Petersén Å. iScience 2022 Jan 19;25(2):103771. doi: 10.1016/j.isci.2022.103771. eCollection 2022 Feb 18. Abstract Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, but underlying mechanisms are not fully known. As the IKKβ/NF-κB pathway is an

https://www.huntington-research.lu.se/ikkb-signaling-mediates-metabolic-changes-hypothalamus-huntingtons-disease-mouse-model-0 - 2026-05-09

Microarray profiling of hypothalamic gene expression changes in Huntington’s disease mouse models

Dickson E, Sai Dwijesha A, Andersson N, Lundh S, Björkqvist M, Petersén Å and Soylu-Kucharz R. Frontiers in Neuroscience. 2022 Nov 3;16:1027269. doi: 10.3389/fnins.2022.1027269. PMID: 36408416; PMCID: PMC9671106. Abstract Structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of Huntington’s disease (HD), a neurodegenerative diso

https://www.huntington-research.lu.se/microarray-profiling-hypothalamic-gene-expression-changes-huntingtons-disease-mouse-models - 2026-05-09

Twisting mice move the dystonia field forward

Petersén Å1 and Kirik D2.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.2Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.Journal of Clinical Investigation 17:1-3 (2014)AbstractA common form of the hyperkinetic movement disor

https://www.huntington-research.lu.se/twisting-mice-move-dystonia-field-forward - 2026-05-09

Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients

Hellem MNN, Cheong RY, Tonetto S, Vinther-Jensen T, Hendel RK, Larsen IU, Nielsen TT, Hjermind LE, Vogel A, Budtz-Jørgensen E, Petersén Å and Nielsen JE. Parkinsonism and Related Disorders. 99: 23-29 (2022).  Abstract Objective: Huntington's disease (HD) is an inherited neurodegenerative disease with motor, cognitive and psychiatric symptoms. Non-motor symptoms like depression and altered social c

https://www.huntington-research.lu.se/decreased-csf-oxytocin-relates-measures-social-cognitive-impairment-huntingtons-disease-patients - 2026-05-09

Oxytocin in Huntington’s disease and the spectrum of amyotrophic lateral sclerosis-frontotemporal dementia

Bergh S, Cheong R Y, Petersén Å and Gabery S. Front. Mol. Neurosci., 14 September 2022; Sec. Molecular Signalling and Pathways; doi.org/10.3389/fnmol.2022.984317   Abstract Neurodegenerative disorders (NDDs) such as Huntington’s disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by progressive loss of selectively vulnerable popu

https://www.huntington-research.lu.se/oxytocin-huntingtons-disease-and-spectrum-amyotrophic-lateral-sclerosis-frontotemporal-dementia - 2026-05-09

Comorbidities and clinical outcomes in adult- and juvenile-onset Huntington's disease: a study of linked Swedish National Registries (2002-2019)

Furby H, Moore S, Nordstroem A-L, Houghton R, Lambrelli D, Graham S, Svenningsson P and Petersén Å. Journal of Neurology. 270(2): 864-876 (2023) doi:10.1007/s00415-022-11418-y. Abstract Background: Huntington's disease (HD) is a rare, neurodegenerative disease and its complex motor, cognitive and psychiatric symptoms exert a lifelong clinical burden on both patients and their families. Objective:

https://www.huntington-research.lu.se/comorbidities-and-clinical-outcomes-adult-and-juvenile-onset-huntingtons-disease-study-linked - 2026-05-09

TIllgänglighetsformulär

Beskrivning av hur webplatsen brister i tillgänglighet (obligatorisk) Webadress till sidan (obligatorisk) Detta måste vara en extern URL som t.ex. http://example.com. Bristen i tillgänglighet med hjälpmedel Om bristen i tillgänglighet beror på att webbplatsen inte fungerar med något hjälpmedel du använder, beskriv det och vilka hjälpmedel det är. Vilket operativsystem och vilken webläsare använder

https://www.msf.lu.se/formular/tillganglighetsformular-0 - 2026-05-09

9th Öresund Workshop on Radiotherapy - October 5-6, 2022

    Welcome to the 9th Öresund Workshop on Radiotherapy, October 5-6, 2022 The annual Öresund Workshop on Radiotherapy is open for professionals and researchers at the radiotherapy-related departments in Gothenburg, Lund, Rigshospitalet and Herlev. The concept of the meeting is based on many presentations from the participants, as well as interactive sessions. It is an excellent opportunity to kee

https://www.msf.lu.se/9th-oresund-workshop-radiotherapy-october-5-6-2022 - 2026-05-09

Registration for the 9th Öresund Workshop on Radiotherapy

Registration and abstract submission can only be made through this web form. Deadline will be on January 18, 2022. If you discover later that you need to cancel or make any changes to your registration, please notify us by email at your earliest convenience. Statusmeddelande Detta formulär är tyvärr stängt för nya inlämningar. Leave this field blank

https://www.msf.lu.se/formular/registration-9th-oresund-workshop-radiotherapy - 2026-05-09

XenX User Meeting 2022

The first XenX user meeting will take place on May 25, starting at 1 pm. To support interaction and possible synergy between user groups, participants will be given the opportunity to present their work. After the user presentations there will also be time for sharing experiences over some snacks. Please sign up using the form below before April 30. More information about venue and program will fo

https://www.msf.lu.se/formular/xenx-user-meeting-2022 - 2026-05-09

10th Öresund Workshop on Radiotherapy - March 1-2, 2023

Welcome to the 10th Öresund Workshop on Radiotherapy, March 1-2, 2023 The annual Öresund Workshop on Radiotherapy is open for professionals and researchers at the radiotherapy-related departments in Gothenburg, Lund, Rigshospitalet and Herlev. The concept of the meeting is based on many presentations from the participants, as well as interactive sessions. It is an excellent opportunity to keep up

https://www.msf.lu.se/10th-oresund-workshop-radiotherapy-march-1-2-2023 - 2026-05-09

Low-field MRI

Background MRI at low field strength has re-emerged as a hot research topic in the last few years largely due to advantages including: reduced costs, lower power and infrastructure requirements, and potential for making the scanner portable. Our group in Lund is part of a multi-national research consortium called UNITY (Ultra-low field NeuroImaging in The Young), financed by the Bill and Melinda G

https://www.msf.lu.se/research/mr-physics-group/research-environments/low-field-mri - 2026-05-09

Ny som student

Har du blivit antagen till Sjukhusfysikerutbildningen ? Grattis och välkommen! Här följer praktiskt information. Kom ihåg att tacka ja till din platsFör att behålla din plats på Sjukhusfysikerutbildningen måste du tacka ja till din plats på antagning.se.Om antagningsbesked och svar samt viktiga datum på antagning.se.Introduktionsmöte, informationsföreläsning och välkomstbrevSjukhusfysikerutbildnin

https://www.msf.lu.se/sjukhusfysikerutbildning/om-utbildningen/ny-som-student - 2026-05-09

Forskningsprojekt avseende MSF:s utbildning på forskarnivå

Målgrupp för denna information: Personer som disputerat för doktorsexamen inom forskarutbildningsämnena radiofysik och medicinsk strålningsfysik i Lund, vid Naturvetenskaplig fakultet, Lunds universitet, under tidsperioden 1969-2023Forskningsprojekt avseende utbildningstid och doktorsavhandlingars omfattning i forskarutbildningsämnena radiofysik och medicinsk strålningsfysik vid Naturvetenskaplig

https://www.msf.lu.se/forskningsprojekt-avseende-msfs-utbildning-pa-forskarniva - 2026-05-09

Studieuppehåll och studieavbrott

StudieuppehållStudieuppehåll innebär att du gör tillfälligt uppehåll i påbörjade studier på en utbildning och att du har för avsikt att återuppta studierna igen vid en senare tidpunkt. För att beviljas studieuppehåll och garanterad plats vid återkomst till utbildningen behöver du kunna styrka särskilda skäl, se nedan. Om du anger att du önskar studieuppehåll exempelvis från och med höstterminen 20

https://www.msf.lu.se/sjukhusfysikerutbildning/studiehandboken/studieuppehall-och-studieavbrott - 2026-05-09