The 'antiporter module' of respiratory chain Complex I includes the MrpC/NuoK subunit - a revision of the modular evolution scheme
Respiratory chain Complex I or NADH:quinone oxidoreductase catalyzes oxidation of NADH in the mitochondrial matrix or bacterial cytoplasm and reduction of quinone in the membrane, coupled to pumping of 4H+/2e- across the membrane. The same enzyme complex is also capable of the reverse reaction, i.e. @D@mH+-supported NAD+ reduction. The molecular mechanism that couples electron transfer to proton p
