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The i-motif tetrameric structure is built up from two parallel duplexes intercalated in a head-to-tail orientation, and held together by hemiprotonated cytosine pairs. Two topologies exist for the i-motif structure, one with outermost 3' extremities and the other with outermost 5' extremities, called the 3'E and 5'E topology, respectively. Since the comparison of sugar and phosphate group interact
The incorporation of drugs into Gelucires has been reported to increase the dissolution rate of poorly soluble drugs, often leading to improved drug bioavailability. In pharmaceutical applications, it is important to know how the excipient interacts with the drug, and how the mixture behaves during manufacturing, storage as well as during administration. The uptake of water by an amphiphilic excip
We performed a physiological and morphological characterization of sensilla auricillica in male Eriocrania semipurpurella moths. Each auricillic sensillum contained three olfactory receptor neurons. Responding neurons (87 of 139) could be grouped into five physiological types. Type 1 responded to (R,Z)-6-nonen-2-ol and type 2 to its enantiomer (S,Z)-6-nonen-2-ol, both of which are pheromone compon
Objective: To describe the principles and operation of a new telemetry-based function test for the Nucleus (R) cochlear implant, known as the CS19 Intra-Cochlear Impedance Matrix (IIM) and to present results from a multicentre clinical study to establish reproducibility (test-retest reliability) and normative ranges. Method: The IIM test measures bipolar impedances between all electrode pairs and
Gel dosimetry measures the absorbed radiation dose with high spatial resolution in 3D. However, recently published data show that the response of metacrylic-based polymer gels depends on the segmented delivery pattern, which could potentially be a considerable disadvantage for measurements of modern dynamic radiotherapy techniques. The aim of this study is to design a dynamic compartment model for
Mobile communication systems are becoming increasingly heterogeneous as new standards emerge. Currently, the wireless operators are upgrading their existing 3G networks such as UMTS and CDMA2000 to different kinds of 4G networks such as LTE and WiMAX. We can witness these days that mobile terminals are having the capability to access many of these wireless network types. The networks are very diff
Current developments in genetics and genomics entail a number of changes and challenges for society as new knowledge and technology become common in the clinical setting and in society at large. The relationship between genetics and ethics has been much discussed during the last decade, while the relationship between genetics and the political arena-with terms such as rights, distribution, experti
The artistic doctoral project Singing in action – processes of vocal improvisation is an investigation of vocal improvised performance from my point of view as a classically trained singer and vocal improviser. It focuses on an artistic tradition which has its roots in medieval Provence and Italy (Wilén, 2013a) and which is an expanding classical vocal genre of today: opera and art song improvisat
In the wake of the war and occupation of Iraq, 2003–2004, international legal scholars struggled to understand and adequately describe the event and the law surrounding it. This study takes that situation of uncertainty as its point of departure, and it unfolds through an analysis of the material conditions and linguistic–rhetoric and affective–psychic registers through which the Administrator of In the wake of the war and occupation of Iraq, 2003–2004, international legal scholars struggled to understand and adequately describe the event and the law surrounding it. This study takes that situation of uncertainty as its point of departure, and it unfolds through an analysis of the material conditions and linguistic–rhetoric and affective–psychic registers through which the Administrator of
In order to distinguish various film-worlds among themselves and from our intersubjective, shared reality I propose to introduce two parameters: warpedness and enfoldednes. The various ratios between these two parameters serve to create what I call »the film-world map«. The time-imageʼs embeddedness within the temporal dimension is what I mean by strong enfoldedness. A world that is enfolded is a
We have all experienced how a telephone conversation can be more challenging than speaking face to face. Understanding the intended meaning of a speaker‘s words requires forming an impression of the current mental state of the speaker, including her beliefs, intentions, and emotional state (Sperber & Wilson, 1995). Facial expressions are an important source of this information. In this study,
This book argues that we are currently witnessing not merely a decline in the quality of social science research, but the proliferation of meaningless research, of no value to society, and modest value to its authors - apart from securing employment and promotion. The explosion of published outputs, at least in social science, creates a noisy, cluttered environment which makes meaningful research
In order to understand how visions and narratives about the Internet are articulated, negotiated, and circulated in China, one needs to address and unpack a number of interrelated issues. It is important to map who has the possibility to articulate visions on the Internet in China, who is actually doing it and why, what having a ‘vision’ actually means, and which platforms different individuals an
Even though anthropogenic nano-sized tungsten carbide nanoparticles (WC NPs) have been found in the environment, there are currently no investigations on their environmental fate. This work studies the interaction between natural organic matter (NOM) and WC NPs, as well as the potential uptake by the aquatic model organism Daphnia magna. We here show that the affinity between WC NPs and humic acid
We present estimates of standardized selection (directional and quadratic) differentials via reproductive success on eight morphological traits in a newly founded long-term study population of great reed warblers Acrocephalus arundinaceus in Sweden. In order to predict the evolutionary response to selection in these traits we present estimates of heritabilities (h(2)), phenotypic (r(P)) and geneti
The fractional dispersion model for natural rivers, extended by including a first order reaction term, contains four parameters. In order to estimate these parameters a fractional Laplace transform-based method is developed in this paper. Based on 76 dye test data measured in natural streams, the new parameter estimation method shows that the fractional dispersion operator parameter F is the contr
In order to obtain biomarker values that reflect body burden of persistent organohalogen pollutants (POP), concentrations of lipophilic POP in serum or plasma are generally expressed on a lipid weight basis, and not on a fresh weight basis. There are two different approaches to determine the lipid content in serum and plasma. The gravimetric determination is more expensive, and longer experience i
BACKGROUND: Human glandular kallikrein 2 (hK2) and prostate-specific antigen (PSA) are members of an extensive kallikrein family of proteases. Both proteases are secreted as zymogens or proenzymes containing a seven amino acid propeptide that must be proteolytically removed for enzymatic activation. The physiological proteases that activate pro-hK2 and pro-PSA are not known. METHODS: The pro-hK2 p
Within the paradigm of population dynamics a central task is to identify environmental factors affecting population change and to estimate the strength of these effects. We here investigate the impact of observation errors in measurements of population densities on estimates of environmental effects. Adding observation errors may change the autocorrelation of a population time series with potentia
Malignant hyperthermia susceptibility is diagnosed using an in vitro contracture test (IVCT). In families in which the mutation is known, genetic tests are also available. The inheritance pattern is regarded as autosomal dominant, which predicts equal proportions of men and women affected. The aim of this study was to investigate whether there were sex differences in the diagnostic outcome of the
