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We discovered structurally novel human calcium-sensing receptor (CaSR) allosteric agonists and compared their pharmacology to phenylalkylamine calcimimetics. 1-Benzothiazol-2-yl-1-(2,4-dimethyl-phenyl)-ethanol (AC-265347) activated CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays with potencies of 30 and 10 nM, respectively. (S)-1-Benzothiazol-2-yl-1-(2,4-di
The purpose of this thesis was to study secondary school students' motivation to learn a second foreign language in addition to English. In addition to the empirical investigation of L3 motivation over a program of study and the testing of the widely-held assumption that L2 English impacts negatively on L3 motivation, the aim was also to contribute to the conceptual development of self-based motiv
Background: The understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles or the efficiency for medical drug delivery via the lung. However, there are few experimental data on particle respiratory tract deposition, and the existing data deviates considerably when comparing results for particles > 1 μm. Methods: We designed an experim
Background: Deep learning convolutional neural networks (CNN) may facilitate melanoma detection, but data comparing a CNN's diagnostic performance to larger groups of dermatologists are lacking.Methods: Google's Inception v4 CNN architecture was trained and validated using dermoscopic images and corresponding diagnoses. In a comparative cross-sectional reader study a 100-image test-set was used (l
Background: Many people ageing with late effects of polio (LEoP) experience new or increased impairments which could negatively influence daily life. Currently, there is limited knowledge how LEoP-related impairments change over time. Objectives: To assess how various self-reported impairments change over 10 years among people with LEoP, and explore factors associated with the changes. Methods: Th
This thesis explores the interactions between cells and nanowires, to increase our understanding of how cells are affected and how they can be manipulated by these one-dimensional, semiconductor crystals (lengths 1-10 µm, diameters <100 nm). These are much smaller than most mammalian cells (10-30 µm in diameter), and it is generally held that nanowires can be interfaced with cells without adverse
There are more than eighty international agreements and many additional programmes dealing with technology transfer. Moreover, several international conventions require that aid programs, both to address acute emergencies and to assist in the longer-term building of viable infrastructures, be undertaken in specific and concrete ways. However, problems inevitably arise when good intentions are put
Abstract in UndeterminedIn the humanitarian context, gender mediates access to aid. The gender of the beneficiary is not only intrinsically linked with her/his disaster vulnerability (Enarson, 2002), but also to their ability to physically access aid distribution points (Lutz and Gady, 2004) and even to be considered a beneficiary in the first place. There is, however, yet another factor mitigatin
BACKGROUND: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail.METHODS
Water security offers to the local population an adequate quality and quantity of water for health, economy, livelihoods and ecosystems. Hence, achieving basic levels of water security should be a priority in areas where access to fresh water is scarce. The Punata alluvial fan (Bolivia) is a semiarid zone and an important agricultural zone, where the main source of water is groundwater. Therefore,
BACKGROUND: There has been a growing body of evidence associating consumption of ultra-processed foods (UPF) with adverse health outcomes including depression, cardiovascular disease, all-cause mortality. However, whether UPF are associated with dementia is unknown. The authors investigated the associations between UPF and dementia incidence in UK biobank.METHODS: We included 72,083 participants (
Background: Alzheimer’s disease (AD) is foremost characterized by β-amyloid (Aβ)-extracellular plaques, tau-intraneuronal fibrillary tangles (NFT), and neuroinflammation, but over the last years it has become evident that peripheral inflammation might also contribute to the disease. AD patients often demonstrate increased levels of circulating proinflammatory mediators and altered antibody levels
Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2 m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and biocl
Enligt svensk processrätt råder som huvudregel fri bevisvärdering och fri bevisföring. Fri bevisföring innebär att det som utgångspunkt inte får finnas någon begränsning av vilken sorts bevisning som presenteras i en rättegång. Detta hänger samman med den fria bevisvärderingen som innebär att det inte finns några regler gällande hur en viss typ av bevisning får värderas. Vidare har enligt artikel According to Swedish procedural law, the process of production of evidence and the evaluation of evidence should be free. That the production of evidence is free means that, as a general rule, there must be no restriction on the type of evidence presented in trial. This is connected with the free evaluation of evidence, which means that there must be no rules regarding how a certain type of eviden
Gender-based violence survivors have barriers to access to justice around the globe. However, States are responsible for removing those barriers and ensuring that everyone can access needed services and justice without discrimination regardless of their gender, sexual orientation, race, nationality, disability, or age. Turkey is no exception with its international commitments and domestic laws to
Vacation or staycation? Seasonal migration is common practice among many different species, including many birds. Birds living in cold climates, such as Scandinavia, experience food shortage during the winter months. Thus, many chose to vacation abroad where the climate is warmer and food is plentiful. However, not all bids in a population make the move – some stay put. This is known as partial
The purpose of this research is to achieve a deeper insight of the emulsifying, suspending, and gelling properties of the meat proteins and see the possibility to use them to produce reduced-salt emulsion-type sausages. Sarcoplasmic and myofibrillar proteins were extracted from pork (longissimus dorsi, LD). Firstly, their aggregation behaviors in different salt concentrations – namely, 0.15 M, 0.4
Diabetes mellitus är en av vår tids största folksjukdomar och påverkar miljontals människor runtom i världen. World health organization (WHO) uppskattade att ungefär 422 miljoner vuxna led av diabetes 2014 och att diabetes orsakade 1,5 miljoner dödsfall 2012. I Sverige beräknas ca 1 miljon människor lida av diabetes eller vara i riskzonen för att utveckla diabetes. Antalet människor som berörs attPrevious studies have shown that increased incorporation of odd chain saturated fatty acids (OCFAs) into plasma phospholipids is associated with a lower future risk of developing type 2 diabetes and that decreased levels of OCFAs are linked to increased insulin resistance. Since the β-cell plays a pivotal role in the progression of type 2 diabetes it is of interest to investigate if elevated level
Syftet med denna uppsats är att, genom att använda en rättsdogmatisk metod och ett kritiskt perspektiv, utreda huruvida en sådan processuell preklusionsregel som föreslagits i SOU 2015:12 Överprövning av upphandlingsmål m.m. bör införas i upphandlingslagarna. Den föreslagna lagen skulle innebära att en part till stöd för sin talan får åberopa nya omständigheter och bevis först i kammarrätten endasThe purpose of this essay is to, by using a legal dogmatic method and a critical perspective, investigate whether a procedural rule of preclusion as proposed in SOU 2015:12 Överprövning av upphandlingsmål m.m. should be passed into the acts of public procurement. The proposed law would imply that a party as support of its action is allowed to refer to new circumstances and evidences for the first
Increasing demand for metals might lead to extraction of metals from materials, previously, thought of as waste. A letter by the Swedish Environmental Protection Agency and Geological Survey of Sweden from 2017 encouraged new and innovative waste treatments as well as recycling of waste produced in association with mining. The conventional treatment of acid mine wastewater creates large volumes of
