The aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is a defining characteristic of Alzheimer's disease. Because of the complexity of this aggregation process, effective therapeutic inhibitors will need to target the specific microscopic steps that lead to the production of neurotoxic species. We introduce a strategy for generating fibril-specific antibodies that selectively suppres

This paper uses an analytical framework of multi-level and multi-phase perspectives to explore low carbon transition pathways for the UK road transport system. The work draws on the impact made by the national (UK) and regional (EU) low carbon policy instruments on the UK road sector. The results show that the transformation pathway, which is at the take-off phase on a large scale, is the only ful

Major socio-ecological issues such as climate change have a global character. For the atmosphere it does not matter from which point in the world greenhouse gases are emitted. The structural preconditions for any ‘good life’ likewise have global reach. In this chapter, we theorise and operationalise the individual, social and ecological dimensions for prosperity and the ‘good life’ at national lev

The eye-tracking method was used to assess the influence of detailed, colorful illustrations on reading behaviors and learning outcomes. Based on participants’ subjective ratings in a pre-study, we selected eight one-page human anatomy lessons. In the main study, participants learned these eight human anatomy lessons; four were accompanied by detailed illustrations, and the other four were accompa

Source location for real aperture radar (RAR) has raised many concerns in the fields of ground-based monitoring for aircrafts and vessels. Notably, the resolution of RAR in azimuth is constrained by the antenna beam width, which results in low degree of location accuracy. In this paper, we exploit the inherent sparseness of the target distributions to formulate a superresolution methodology to loc

Background Abdominal symptoms are diagnostically challenging to general practitioners (GPs): although common, they may indicate cancer. In a prospective cohort of patients, we examined abdominal symptom frequency, initial diagnostic suspicion, and actions of GPs in response to abdominal symptoms. Methods Over a 10-day period, 493 GPs in Norway, Denmark, Sweden, Belgium, the Netherlands, and Scotla

COORDINATION OF WORD ONSET ARTICULATORY GESTURES IN SWEDISH: ANTICIPATORY CUES TO WORD ACCENTS

Highly collimated betatron radiation from a laser wakefield accelerator is a promising tool for spectroscopic measurements. Therefore, there is a requirement to create spectrometers suited to the unique properties of such a source. We demonstrate a spectrometer which achieves an energy resolution of 1800) and is angularly resolving the x-ray emission allowing the reference and spectrum to be recor

Background: Injury by the sting of Lesser weever fish (Trachinus vipera) may lead to severe pain, edema or tissue necrosis. Cellular effects of the venom are still incompletely understood. Previous observations revealed that purified Lesser weever fish venom (LWFV) induces suicidal death of erythrocytes and HCT116 human colon carcinoma cells. The present study addressed the effect of the venom on

Multi-particle cumulants and corresponding Fourier harmonics are measured for azimuthal angle distributions of charged particles in pp collisions at s = 5.02 and 13 TeV and in p + Pb collisions at sNN = 5.02 TeV, and compared to the results obtained for low-multiplicity Pb+Pb collisions at sNN = 2.76 TeV. These measurements aim to assess the collective nature of particle production. The measuremen

The tracking performance parameters of the ATLAS Transition Radiation Tracker (TRT) as part of the ATLAS inner detector are described in this paper for different data-taking conditions in proton-proton, proton-lead and lead-lead collisions at the Large Hadron Collider (LHC). The performance is studied using data collected during the first period of LHC operation (Run 1) and is compared with Monte

Cross section and S factor of the proton- and alpha-induced reactions have been studied for the Ruthenium and tin isotopes in the effective energy range, i.e. Gamow window. These reactions are important for developing the understanding for nucleosynthesis, particularly for the synthesis of p nuclei (p process). In this work, cross sections and S factor have been calculated through TALYS in Hauser–

Superhard cutting tool materials were sintered in cBN–(Ti3SiC2–TiC) system via high pressure–high temperature method. Sintering was performed under the pressure 8 GPa in the 1400–2400°C temperature range. The initial mixtures of three compositions were chosen with 90, 80 and 60 vol % cBN. The mixtures were prepared by mixing cBN (1–3 μm) and Ti3SiC2–TiC (< 2 μm). It was found, that upon sintering,

The present review covers a wide scope of occupational heat stress related issues. The problematics related to climate change have placed heat exposure on the agenda. As a result, the research on heat effects has increased in recent years and a considerable amount of new material has become available. The literature includes general and specific reviews that focus on various heat-related aspects i