2-Hydroxypyridine-Ligated Pd-complexes as pre-catalysts in Hydrogen Borrowing Chemistry α -Alkylation of Ketones Using Alcohols
An efficient method for selective alpha-alkylation of ketones with alcohols was developed using 2-hydroxypyridine-based ligands coordinated by palladium as pre-catalysts. The reactions were performed without additional additives under mild reaction conditions. The method is environmentally friendly to build C-C bond as water is the only byproduct. This tandem reaction proceeds via dehydrogenation