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M giants with IGRINS : III. Abundance trends for 21 elements in the solar neighborhood from high-resolution near-infrared spectra

Context. To be able to investigate the chemical history of the entire Milky Way, it is imperative to also study its dust-obscured regions in detail, as this is where most of the mass lies. The Galactic Center is an example of such a region. Due to the intervening dust along the line of sight, near-infrared spectroscopic investigations are necessary to study this region of interest.Aims. The aim of

Electronic Correlations in Multiferroic Van der Waals CuCrP2S6 : Insights from X-ray Spectroscopy and DFT

The electronic structure of high-quality van der Waals multiferroic CuCrP2S6 crystals was investigated by applying photoelectron spectroscopy methods in combination with DFT analysis. Using X-ray photoelectron and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy at the Cu L2,3 and Cr L2,3 absorption edges, we determine the charge states of ions in the studied compound. Analyzing the

Predicting developmental deficiencies at the age of four based on data from the first seven months of life

The study examines very Young children with the aim of identifying precursors of developmental problems during, the first 7 months of age. Information front screening, and observations in the birth clinic, in the first level of health care. and from parents was collected on five different occasions. The information that Was included concerning the child and family was defined as either optimal or

Comparison between two extreme NAO winters and consequences on the thermal regime of Lake Vendyurskoe, Karelia

For 10 consecutive winters, measurements were carried out in Lake Vendyurskoe, Karelia, Russia. The aim of these measurements was to investigate some of the physical processes in this small shallow lake during its ice-covered period. Detailed measurements of ice thickness and condition, snow thickness, water temperature, salt content, and currents were developed into a database. Within this databa

Hypoglycaemia leads to an increased QT interval in normal men

Hypoglycaemia is presumed to be the cause of death in about 3% of insulin-treated diabetic patients. Some of these patients suffer from hypoglycaemic brain damage, but the majority have no evident brain damage and are supposed to have died from other causes such as a cardiac arrhythmia. The putative mechanism is a hypoglycaemia-induced prolongation of the QT interval which increases the risk of ma

Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials

BACKGROUND: In early breast cancer, variations in local treatment that substantially affect the risk of locoregional recurrence could also affect long-term breast cancer mortality. To examine this relationship, collaborative meta-analyses were undertaken, based on individual patient data, of the relevant randomised trials that began by 1995. METHODS: Information was available on 42,000 women in 78

Selective targeting of primary and secondary nucleation pathways in Ab42 aggregation using a rational antibody scanning method

Antibodies targeting Ab42 are under intense scrutiny because of their therapeutic potential for Alzheimer’s disease. To enable systematic searches, we present an “antibody scanning” strategy for the generation of a panel of antibodies against Ab42. Each antibody in the panel is rationally designed to target a specific linear epitope, with the selected epitopes scanning the Ab42 sequence. By screen

Optimal proportional–integral–derivative set-point weighting and tuning rules for proportional set-point weights

In this study, design of low-order feedforward controllers from both reference signal and measurable disturbance for proportional–integral–derivative (PID) controllers is considered. The feedforward controllers from reference are equivalent to the use of a PID controller with set-point weighting. The design problem is formulated as a convex optimisation problem and then solved for a batch of proce

Chronology and styles of glaciation in an inter-fjord setting, northwestern Svalbard

A 30-m-thick sedimentary succession at Leinstranda on the southwestern coast of Br circle divide ggerhalv circle divide ya, northwestern Svalbard, spans the two last glacial-interglacial cycles and reveals information on glacial dynamics, sea-level changes and the timing of these events. We investigated the deposits using standard stratigraphical and sedimentological techniques, together with grou

Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening.

This paper contains a joint ESHG/ASHG position document with recommendations regarding responsible innovation in prenatal screening with non-invasive prenatal testing (NIPT). By virtue of its greater accuracy and safety with respect to prenatal screening for common autosomal aneuploidies, NIPT has the potential of helping the practice better achieve its aim of facilitating autonomous reproductive

Automatic ultrarapid activation and inhibition of cortical motor systems in spoken word comprehension

To address the hotly debated question of motor system involvement in language comprehension, we recorded neuromagnetic responses elicited in the human brain by unattended action-related spoken verbs and nouns and scrutinized their timecourse and neuroanatomical substrates. We found that already very early on, from similar to 80 ms after disambiguation point when the words could be identified from

Robust Surface Doping of Bi2Se3 by Rubidium Intercalation

Rubidium adsorption on the surface of the topological insulator Bi2Se3 is found to induce a strong downward band bending, leading to the appearance of a quantum-confined two-dimensional electron gas state (2DEG) in the conduction band. The 2DEG shows a strong Rashba-type spin orbit splitting, and it has previously been pointed out that this has relevance to nanoscale spintronics devices. The adsor

Evaluating the Machinability of Inconel 718 Using Polar Diagrams

Abstract in UndeterminedThe use of a polar diagram method for describing and evaluating the machinability ofInconel 718 was explored. Five key parameters of the work material, representing themechanical and physical properties, which have the strongest influence on its machinability,were employed in the diagrams. These five parameters were integrated into asingle polar diagram, used to describe th

Off-resonance rotating-frame relaxation dispersion experiment for (13)C in aromatic side chains using L-optimized TROSY-selection.

Protein dynamics on the microsecond-millisecond time scales often play a critical role in biological function. NMR relaxation dispersion experiments are powerful approaches for investigating biologically relevant dynamics with site-specific resolution, as shown by a growing number of publications on enzyme catalysis, protein folding, ligand binding, and allostery. To date, the majority of studies

Retarded sorption in wood : experimental study, analyses and modeling

Models of moisture flow processes in wood are normally based on a Fickian approach. In many instances, there are considerable discrepancies between modelling and experimental results. It is shown in this thesis that a major cause for these discrepancies is a so-called retarded sorption which is not accounted for in conventional theories. This retarded sorption occurs in the wood cell wall. A spec

Prevention of progression to severe obesity in a group of obese schoolchildren treated with family therapy

STUDY OBJECTIVE. To evaluate the effect of family therapy on childhood obesity. DESIGN. Clinical trial. One year follow-up. SETTING. Referral from school after screening. PARTICIPANTS. Of 1774 children (aged 10 to 11), screened for obesity, 44 obese children were divided into two treatment groups. In an untreated control group of 50 obese children, screened in the same manner, body mass index (BMI

The utility of the GHRH-arginine test for diagnosing GH deficiency in adults with childhood acute lymphoblastic leukemia (ALL) treated with cranial irradiation.

Context: The insulin tolerance test ( ITT) is the current standard diagnostic test for the diagnosis of adult GH deficiency ( GHD), but alternative tests, such as the GHRH- arginine test, have been proposed. Objective: We investigated the sensitivity and specificity of the GHRH- arginine test using ITT as the gold standard in diagnosing GHD in a group of young adults treated with cranial irradiati

Incidence of diabetes in middle-aged men is related to sleep disturbances.

OBJECTIVE—Sleep deprivation in healthy men has been experimentally found to result in disturbances in glucose metabolism and in sympathovagal imbalance. The aim of the present study was to investigate whether sleep disturbances and elevated resting heart rate are associated with increased risk of developing diabetes. RESEARCH DESIGN AND METHODS—A group of 6,599 initially healthy, nondiabetic men