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Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR
The correct folding of proteins is of paramount importance for their function, and protein misfolding is believed to be the primary cause of a wide range of diseases. Protein folding has been investigated with time-averaged methods and time-resolved spectroscopy, but observing the structural dynamics of the unfolding process in real-time is challenging. Here, we demonstrate an approach to directly
One of the functional proteins in rapeseed-the amphiphilic protein oleosin-could be used to stabilize emulsions. The objectives of this study were to extract oleosins from cold-pressed rapeseed press-cake, optimize the extraction process, and investigate their emulsifying and anti-oxidative capacity. The proteins were recovered from industrially cold-pressed rapeseed press-cake at different alkali
A paradigm shift is emerging in universities especially regarding how personalized and collaborative mobile learning should be addressed. Recently three international benchmarking projects on quality of e-learning in higher education have been carried out by Lund University in Sweden. These showed that quality has to be valued from a holistic perspective and to a higher extent from learning dimens
Popular Abstract in Swedish Syftet med denna avhandling är att skapa en bättre förståelse för vilken betydelse institutioner har för innovationsprocesser inom regionala innovationssystem. Den fokuserar särskilt på hur olika typer av institutioner på skilda geografiska nivåer samspelar; hur institutionell påverkan förändras i samband med att innovationsprocesser utvecklas över tid; samt vilka möjliEconomic geographers have long been intrigued by the role of institutions in innovation processes. It has been argued that differences in institutions are among the factors explaining the uneven innovative capacity across and within countries. The regional innovation system approach highlights the interrelationships of firms, universities, governmental authorities and other organizations, as well
Sources of elemental carbon (EC) and organic carbon (OC) in atmospheric aerosols (carbonaceous aerosols) were investigated by collection of weekly aerosol filter samples at six background sites in Northern Europe (Birkenes, Norway; Vavihill, Sweden; Risoe, Denmark; Cabauw and Rotterdam in The Netherlands; Melpitz, Germany) during winter 2013. Analysis of 14C and a set of molecular tracers were use
Popular Abstract in Swedish Dagens samhälle är väldigt beroende av fordon av olika slag. Aldrig förr har människor rest till olika delar av världen, så mycket som idag. Den enorma mängden resors och transporter som sker varje dag är en tung belastning för vår natur. Bilar och lastbilar, som ökar i antal varje dag, släpper ut giftiga avgaser på vägarna och flygplan förbrukar enorma mängder fossilt Urban traffic involves frequent acceleration and deceleration. During deceleration, the energy previously used to accelerate the vehicle is mainly wasted on heat generated by the friction brakes. If this energy that is wasted in traditional internal combustion engines (ICE) could be saved, the fuel economy would improve. Today there are several solutions to meet the demand for better fuel economy
Galactoglucomannans (GGM) can be used as a precursor for the production of surfactants, plastics, hydrogels etc. However, separation of galactoglucomannan (GGM) from lignin and lignin-carbohydrate-complexes using membrane filtration is difficult. Precipitation of GGM with anti-solvents is an approach that has been previously studied. A membrane filtration step prior to precipitation is economicall
In the context of complex intergenerational challenges such as climate change and sustainable development, it is increasingly important for scientists and policy-makers to actively engage with and support the meaningful participation of youth in policy and decision-making. This research evaluates the effectiveness and impact of the Youth in Landscapes Initiative in supporting the active participat
Using unique longitudinal microdata linking administrative records from Sweden and Finland, we study how immigrant naturalization relates to cultural proximity. We analyze how Swedish citizenship acquisition depends on mother tongue by comparing Swedish-speaking and Finnish-speaking immigrants from Finland, who arrived in Sweden in 1988–2004, and contrast with other Nordic-born immigrants. We trea
The Intergovernmental Panel on Climate Change (IPCC) has provided periodic assessments of the state of knowledge on climate change for 30 years. While these assessments have been central to the making of international climate policy, their relevance has been questioned in the post-Paris era. Can the IPCC's global kinds of knowledge match the demands of an increasingly decentralized and polycentric
Background. Natural gas makes a significant contribution to the current energy supply and its importance, in relation to both the German and worldwide energy supplies, will increase further in decades to come. In addition to its high degree of efficiency, the low level of direct GHG combustion emissions is also an advantageous factor. However, around 90% of natural gas is methane (CH4), which is t
The level of extracellular calcium has been demonstrated to regulate important physiological processes like cell growth and apoptosis. We demonstrate that in the bladder cancer cell line RT4, an increased extracellular calcium level induces apoptosis and that the HER1 receptor functions as a cell survival factor and delays apoptosis. After 12 h of calcium treatment (10 mM) apoptosis was detected i
Background and Objectives: Multiple processes have been identified as potential contributors to chronic pain, with increasing evidence illustrating an association with aberrant levels of neuroimmune mediators. The primary objectives of the present study were to examine central nervous system cytokines, chemokines, and growth factors present in a chronic pain population and to explore patterns of t
Background: A velocity offset error in phase contrast cardiovascular magnetic resonance (CMR) imaging is a known problem in clinical assessment of flow volumes in vessels around the heart. Earlier studies have shown that this offset error is clinically relevant over different systems, and cannot be removed by protocol optimization. Correction methods using phantom measurements are time consuming,
During substrate-limited growth, some strains of Thiosphaera pantotropha nitrify heterotrophically and denitrify aerobically. These processes are thought to be used as NADH overflow mechanisms, resulting from a restricted oxygen respiration capacity. In this study, the behavior of T. pantotropha regarding the NADH overflow in the presence of substantial concentrations of substrate was examined. Co
Xylooligosaccharides (XOS) have gained increased interest as prebiotics during the last years. XOS and arabinoxylooligosaccharides (AXOS) can be produced from major fractions of biomass including agricultural by-products and other low cost raw materials. Endo-xylanases are key enzymes for the production of (A)XOS from xylan. As the xylan structure is broadly diverse due to different substitutions,
To examine pathways of glutamate and glutamine metabolism in the ectomycorrhizal fungus Paxillus involutus, tracer kinetic experiments were performed using L-[U-C-14]glutamate and L-[U-C-14]glutamine and the enzyme inhibitors methionine sulfoximine (MSX), azaserine (AZA) and aminooxyacetate (AOA). When [C-14]glutamate was supplied to fungal cultures, 25% of the radioactivity of the amino acid frac
Background: Activated mast cells can produce and release a number of inflammatory mediators involved in the pathophysiological process of acute conditions. The aim of the study was to evaluate the effect of mast cell stimulation on the early development of multiple organ dysfunction (MODS) in acute pancreatitis (AP). Methods: AP was induced by the intraductal infusion of 5% sodium taurodeoxycholat
Interest in the use of renewable raw materials for the production of various compounds that can replace fossil-based products is steadily increasing. In this study, the extraction and separation of hemicellulosic oligomers from spruce, to be used for the production of polymers such as hydrogels, was investigated. The focus of the study was on gel filtration of the solution from steam treatment of
