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Objectives: To investigate the effect of prolonged neutralisation of tumour necrosis factor alpha (TNFalpha) on the radiological course in rheumatoid arthritis (RA). To assess whether the radiological course can be predicted by clinical variables or biological markers of cartilage and synovium turnover and of endothelial activation. Patients and methods: Forty seven patients with active RA enrolle

In this investigation the possibilities to achieve three different goals for sustainable forestry in the landscape of Stenbrohult have been studied: Preserved biodiversity, balanced nutrient budgets, and a valuable production of timber. The consequences for the landscape and for the different estates were studied. The case study area of Stenbrohult is situated in southern Sweden, and is made up of

This work presents an event-based control structure using the generalized predictive control (GPC) algorithm with actuator deadband. The main objective of this work is to limit the number of controlled system updates. In this approach, the controlled process is sampled with a constant sampling time and is updated in an asynchronous way that depends on the obtained control signal value. To achieve

By exposing photosystem II (PSII) samples to an incrementing number of excitation flashes at room temperature, followed by freezing, we could compare the Mn-derived multiline EPR signal from the S-2 oxidation state as prepared by 1, 5, 10, and 25 flashes of light. While the S-2 multiline signals exhibited by these samples differed very little in spectral shape, a significant increase of the relaxa

In an effort to find conditions favouring bioelectrocatalytic reduction of oxygen by surface-immobilised human ceruloplasmin (Cp), direct electron transfer (DET) reactions between Cp and an extended range of surfaces were considered. Exploiting advances in surface nanotechnology, bare and carbon-nanotube-modified spectrographic graphite electrodes as well as bare, thiol- and gold-nanoparticle-modi

In experiments, the feasibility was demonstrated of generating multi-MeV electrons in a form of a collimated beam utilizing a table-top laser system delivering 200 fs pulses with P-L=1.2 TW and 10 Hz capability. The method uses the process of relativistic self-channeling in a high-density gas jet producing electron densities in the range of 3x10(19)-6x10(20) cm(-3). In a thorough investigation, an

This paper contains a joint ESHG/ASHG position document with recommendations regarding responsible innovation in prenatal screening with non-invasive prenatal testing (NIPT). By virtue of its greater accuracy and safety with respect to prenatal screening for common autosomal aneuploidies, NIPT has the potential of helping the practice better achieve its aim of facilitating autonomous reproductive

A new, two-layer canopy module with thermal inertia as part of the detailed snow model SNOWPACK (version 3.2.1) is presented and evaluated. As a by-product of these new developments, an exhaustive description of the canopy module of the SNOWPACK model is provided, thereby filling a gap in the existing literature. In its current form, the two-layer canopy module is suited for evergreen needleleaf f

Pyridinium triflate protic ionic liquids have been demonstrated to be highly dissociated, and nonstoichiometric compositions have been used in protic energy devices such as the all-organic proton battery. Herein, we use a combination of pulsed field gradient NMR spectroscopy and electrochemical impedance spectroscopy to investigate the charge transport properties of the nonstoichiometric protic io

The aim of this study was to investigate potential dose reductions to the heart, left anterior descending coronary artery (LAD), and ipsilateral lung for left-sided breast cancer using visually guided deep inspiration breath-hold (DIBH) with the optical surface scanning system Catalyst™, and how these potential dosimetric benefits are affected by intrafractional motion in between breath holds. For

The objective of this paper is to present the main results of an engineering-research project dealing with model-based evaluation of waste streams treatment from a biotech company. This has been extensively done in domestic treatment systems, but is equally important, and with different challenges in industrial wastewater treatment. A new set of biological (activated sludge, anaerobic digestion),

Background: Early initiation of breastfeeding (EIBF) lowers the risk for all-cause mortality in babies, including those with low birth weight. However, rates of neonatal mortality and delayed initiation of breastfeeding remain high in most low- and middle-income countries. This study aimed to assess the trends and factors associated with EIBF in Namibia from 2000 to 2013. Methods: An analysis of E

When light is used to study structures, the wavelength limits the size of the details that can be resolved. Visible light can be used to investigate structures as small as a micrometre in size. To study smaller structures a shorter wavelength is required. The wavelength of hard X-ray radiation is much shorter than that of visible light, and is comparable to the distance between atoms in solids and

The radionuclides (210)Po and (210)Pb widely present in the terrestrial environment are the final long-lived radionuclides in the decay of (238)U in the earth's crust. Their presence in the atmosphere is due to the decay of (222)Rn diffusing from the ground. The range of activity concentrations in ground level air for (210)Po is 0.03-0.3 Bq m(-3) and for (210)Pb 0.2-1.5 Bq m(-3). In drinking water

Lipid oxidation is a major problem in muscle foods, leading to a loss in quality and nutritional value. It occurs in raw meat but is usually more pronounced in cooked meat. Since the demands of consumers for ready-to-eat foods have increased, the control of off-flavour in cooked meat is an important industrial problem. One way of minimising the development of lipid oxidation is to optimise the act

Wrap Your Troubles into Dreams, är ett praktikbaserat forskningsprojekt. Undersökningen berör stadsomvandlingsprocesser i Stockholmsområdet, speglade genom två politiska förhållningssätt gestaltat i staden: genomförandet av det funktionsseparerade Stockholms City (under 1960-talet) och de senaste decenniernas privatisering av stadsrummet. I forskningen har jag utgått från två platser som i motreakWrap Your Troubles into Dreams is a practice-based artistic research project. The study investigates city transformation processes in the Stockholm area, by viewing them through two political attitudes expressed in the city; the introduction of the function-separated Stockholm City area (during the 1960s) and the privatisation of urban space during the last few decades. I have based my research on

The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75–78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on mult

Personuppgifter blir allt viktigare i den digitala ekonomin. Omfattningen av insamling och behandling ökar och riskerar att hota den personliga integriteten. Trots att personlig integritet och respekten för privatlivet räknas som som en mänsklig rättighet har dessa en väldigt svag position relativt andra rättigheter och samhälleliga behov. Detta ter sig ganska underligt eftersom den personliga intPersonal data is becoming increasingly important in the digital economy. The scope of collection and treatment increases and may threaten personal integrity. Although privacy is regarded as human right, privacy has a very weak position relative other rights and social needs. This is quite strange as privacy is often considered a prerequisite for many of the traditional rights such as freedom of sp

Den 11 januari 2015 trädde Europaparlamentets och rådets direktiv 2011/99/EU av den 13 december 2011 om den europeiska skyddsordern och Europaparlamentets och rådets förordning (EU) nr 606/2013 av den 12 juni 2013 om ömsesidigt erkännande av skyddsåtgärder i civilrättsliga frågor i kraft inom Europeiska unionen. På grund av sin natur behövdes kompletterande bestämmelser införas i svensk nationell On January 11th, 2015, Directive 2011/99/EU of the European Parliament and of the Council of 13 December 2011 on the European protection order and Regulation (EU) No 606/2013 of the European Parliament and of the Council of 12 June 2013 on mutual recognition of protection measures in civil matters entered force in the European union. Due to the complex nature of the regulation, supplementary legis