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This paper contains a joint ESHG/ASHG position document with recommendations regarding responsible innovation in prenatal screening with non-invasive prenatal testing (NIPT). By virtue of its greater accuracy and safety with respect to prenatal screening for common autosomal aneuploidies, NIPT has the potential of helping the practice better achieve its aim of facilitating autonomous reproductive

A new, two-layer canopy module with thermal inertia as part of the detailed snow model SNOWPACK (version 3.2.1) is presented and evaluated. As a by-product of these new developments, an exhaustive description of the canopy module of the SNOWPACK model is provided, thereby filling a gap in the existing literature. In its current form, the two-layer canopy module is suited for evergreen needleleaf f

Evaluating potentially analgesic effects of drugs and various treatments is critically dependent on valid animal models of pain. Since primary somatosensory (SI) cortex is likely to play an important role in processing sensory aspects of pain, we here assess whether monitoring SI cortex nociceptive C fibre evoked potentials can provide useful information about central changes related to hyperalges

Six-membered cyclic carbonates are potential monomers for phosgene and/or isocyanate free polycarbonates and polyurethanes via ring-opening polymerization. A two-step process for their synthesis comprising lipase-catalyzed transesterificationofa polyol, trimethylolpropane(TMP) with dimethylcarbonate(DMC)in a solvent-free system followed by thermal cyclization was optimized to improve process effic

Legal professionals' opinions about the memory abilities of child and adult witnesses are important in the legal process. We surveyed 266 legal professionals (Swedish police, prosecutors, and attorneys) and 33 lay judges about their beliefs about child and adult eyewitnesses' recall and metacognitive abilities. Prior research has usually asked for direct comparisons of children and adults but this

BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic mark

Five molybdenum oxide samples, subjected to conditions of oxidative ammonolysis and ammoxidation of toluene at 450 and 460°C, respectively, have been characterized using X-ray diffraction, scanning and transmission electron microscopy, and specific surface area measurements. In oxidative ammonolysis, the relatively large, freshly prepared MoO3 crystals are reduced to smaller MoO2 crystals with a c

This working paper discusses the different Asian experiences of the Green Revolution from the late 1960s to the 1980s in the perspective of earlier developments of agricultural intensification. The intention of the paper is to identify common features and conditions contributing to the considerable success of Asian agriculture over the past 30 years. The authors argue that the Green Revolution mus

We investigate in detail the effect of electron and light- and heavy-hole state mixing on the transmission coefficients and current-voltage characteristics of interband tunnelling broken-gap heterostructures in the presence of a quantizing magnetic field perpendicular to the interfaces. Double-barrier and barrierless resonant tunnelling structures made from InAs, A1Sb, and GaSb are considered. The

The removal of color and chemical oxygen demand (COD) from simulated dye wastewater containing Acid Orange II was experimentally investigated using coagulation-electrooxidation. Two kinds of coagulation methods, ferrous-mediated coagulation and electrocoagulation were tested as pretreatment. The electrooxidation was carried out in a cell with a three-phase three-dimensional electrode using granula

Four different non-nuclear industries have been investigated regarding the presence of radioactive elements, with the focus on natural radioactivity. The aim of the studies was to investigate the flow of radionuclides in the processes and/or to estimate doses to exposed workers. The first industry investigated was phosphate processing in the manufacture of dicalcium phosphate (DCP), which is used

During south Scandinavian Late Bronze Age, c. 900-500 BC, a new tool was invented. It consisted of a wooden shaft and a knife blade made out of flint. One singel of this tool still exists today. It was found in a Danish bog in late 19th century. But there are many of the knife blades of flint; in museum collections or in flint assemblages from archaeological excavations. Archaeologists call them l

Protein dynamics on the microsecond-millisecond time scales often play a critical role in biological function. NMR relaxation dispersion experiments are powerful approaches for investigating biologically relevant dynamics with site-specific resolution, as shown by a growing number of publications on enzyme catalysis, protein folding, ligand binding, and allostery. To date, the majority of studies

We study agents situated in partially observable environments, who do not have sufficient resources to create conformant plans. Instead, they generate plans which are conditional and partial, execute or simulate them, and learn to evaluate their quality from experience. Our agent employs an incomplete symbolic deduction system based on active logic and situation calculus for reasoning about action

Widespread presence of toxic and persistent pollutants in the environment, even at low concentrations, causes risks of adverse effects to human health and the ecosystem. Biological methods for treatment of water streams and removal of persistent pollutants are of great interest due to their simplicity, low cost, and mild operational conditions without harmful by-products. The purpose of this resea

In an exploratory investigation of personality patterns, Swedish air force pilots (n = 22) and ground officers (n = 14) were tested with the Creative Functioning Test, the Serial Color Word test, and the Spiral After-Effect Technique. The participants also answered open questions about their work and about creativity related items. Achievement ratings were made by their superior officers. An initi

This paper presents the manufacturing experience of an outer rotor permanent magnet synchronous machine with four different stators. The advantageous features of powder technology and molding techniques are tested when constructing and manufacturing the stators for a 28-pole 30-slot machine. The selected machine configuration is taking advantages of the concept of the modular windings and at the s

The modern synthesis of genetics with evolution slanted our understanding of evolution and of ourselves by rejecting Darwin’s view of animals as participating in their own evolution. Defining evolution in terms of genetics, the modern synthesis indulges excessive individualism and distorted self-images as self-made. At the same time, such gene-centred thought, evoking images of master molecules ma

Age-associated and degenerative loss of functional integrity in soft tissues develops from effects of cumulative and subtle changes in their extracellular matrix (ECM). The highly ordered tendon ECM provides the tissue with its tensile strength during loading. As age and exercise collude in the high incidence of tendinopathies, we hypothesized that aged tendons fail due to cumulative damage result