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We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 ×
This paper presents updated Monte Carlo configurations used to model the production of single electroweak vector bosons (W, Z/γ∗) in association with jets in proton-proton collisions for the ATLAS experiment at the Large Hadron Collider. Improvements pertaining to the electroweak input scheme, parton-shower splitting kernels and scale-setting scheme are shown for multi-jet merged configurations ac
City-wide climate adaptation for pluvial flood mitigation requires fast and reliable simulation tools. Considering the limitations of hydrodynamic models at city-scale simulations, data driven models have high potential in the development of surrogate tools. This study explores the Google DeepMind WaveNet™ model architecture to map hydrological response of catchments onto hydraulic parameters of t
In dry sandy soil, soil water is naturally redistributed by forces owing to matric and gravitational potential, and temperature gradients. Occurring shrub vegetation strongly influences these patterns by hydraulic redistribution within the soil. This means that plants can move water from moist to drier soil areas to extract nutrients from the drier soil and enhance nutrient uptake. This incorporat
An experimental investigation of surface pressure distributions (mean and r.m.s.) on two tubes (circular cylinders) mounted in an in-line or tandem arrangement was carried out in a low-speed, closed-circuit wind tunnel. The measurements were mainly performed at a subcritical Reynolds number, Re = 2·0 × 104, at three different turbulence intensities of the approaching cross-flow (0·1, 1·4 and 3·2%)
Hur ska vi komma till rätta med de stora utmaningar som den globala klimatkrisen ställer oss inför? Som individer kan vi alla bidra genom att sortera våra sopor, köra miljövänligt, eller kanske välja att ta cykeln till jobbet. Alla våra individuella bidrag räknas förstås. Men stora delar av vår mänskliga förmåga att förändra världen kommer inte från hur vi agerar var och en, utan från vår gemensamThe world is facing a climate crisis and established firms are set to play a critical role in the societal changes that are needed to defeat it. At the same time, digital technologies are advancing to enable many of the technological solutions that will be required. Together, these two trends, toward greater environmental sustainability and digitalized business, superficially suggest opportunities
Sustainability Science (SS) is known for aspiration to support societies towards ecologically sound trajectories – a fabulously reflexive, ultimately critical and deeply self-aware field with a diverse community of highly skilled and creative researchers of noble goals, rigorous training and active engagement with ‘real life’ (so we claim, or at least aspire for). We try hard to alter extinction o
The study aims to explore the increasingly relevant and theoretically underexplored field of ridesharing as a solution for first and last-mile transportation, its success factors and challenges, as well as the process of integrating ridesharing into a public transport network. It utilizes a business model innovation framework as the theoretical basis to explore success factors as well as challenge
Blockchain technology has in recent years gained significant momentum in a wide variety of industries. However, in the context of SMEs the IS body of research is lacking, both in terms of why SMEs should consider this new technology and the factors that affect a potential adop-tion. To explore this research gap, the authors derived a conceptual framework from the exist-ing literature along with el
This thesis examines the extent to which the French and Swiss models of corporate criminal liability may inform the development of proposals to extend the jurisdiction of the International Criminal Court (ICC) to encompass legal persons. The study employs a combination of doctrinal and comparative legal methodology, with particular emphasis on the legal models through which criminal liability may
Aedes aegypti is one of the most lethal disease vectors in modern history, spreading a majority of the deadliest diseases mediated by mosquitos. To try and combat this, mankind has, for a long time, tried to create repellents to keep the insects away. These repellents affect receptors in the mosquitos, keeping them at bay. One receptor that is highly expressed in the mosquito’s prey/host sensory o
This thesis explores the influence of the current economic paradigm, usually referred to as neoliberalism, on various aspects of life, thereby creating its own psychology. This psychology of neoliberalism, with a strong focus on competitiveness, individualism, and consumerism, creates intertwined dynamics for individuals, public institutions, and society and functions as the backbone of economic g
This project was completed in collaboration with the graph database company Neo4j with the aim of developing a new algorithm for automatic detection of software bugs that degrade system performance, commonly referred to as performance regressions in the industry. Due to the large number of benchmarks used to monitor different aspects of the product environment, a flexible and robust solution was n
My main contribution to the Human Ecology field is exploring the relationship between memories and images of the future when pursuing transition imaginaries. By ‘feeling with the head and reasoning with the heart’, I used a sensory ethnographic method to listen to people's life stories during my fieldwork in Bolivia with territorial defenders. Throughout the data collection and analysis, there
Agonistic peace is an emerging approach in peace studies that advocates for non-violent and political continuation of conflict through transformation of inter-groups relationships so that former antagonists recognize each other as legitimate actors. As of yet, the practical implications of agonistic peace for ending violence and promoting durable peace have been relatively understudied, especially
Urban green space (UGS) refers to open spaces within an urban context that are filled with greenery and nature. These can range from very small vegetation to expansive park areas. The common denominator is that they have proven to be beneficial for human health and well-being. Access to green spaces is also important for children. Research suggests that time spent in green spaces supports the beha
6G technology is set to revolutionize wireless communication, advancing far beyond speed enhancements to reshape how we interact with technology. A key factor in this evolution is the efficient use of the radio spectrum, particularly in the centimetre-wave (FR3) bands, ranging from 7 GHz to 24 GHz. This thesis investigates strategies for adapting FR2 transceivers to operate in FR3 frequencies thro
Streptococcus pyogenes, or group A streptococci (GAS) is a well known agent of pharyngitis. The same goes for the closely related S. dysgalactiae subspecies equisimilis (SDSE). Recent data indicates that a third pathogen called Fusobacterium necrophorum, with similarly severe complications to GAS is the second most common pathogen in pharyngitis. These infections cause the greatest damage in low
