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PMCA4 is a critical regulator of Ca2+ homeostasis in mammalian cells. While its biological and prognostic relevance in several cancer types has already been demonstrated, only preclinical investigations suggested a metastasis suppressor function in melanoma. Therefore, we studied the expression pattern of PMCA4 in human skin, nevus, as well as in primary and metastatic melanoma using immunohistoch
Incumbent firms face growing pressure to transform their business towards sustainability. However, business models for sustainability (BMfS) and circularity are grounded in fundamentally different institutional logic which, for incumbents, creates tensions with existing business models, structures and routines. How organizations manage tensions from conflicting logics is explored comprehensively i
The aim of our study was to test the hypothesis that administration of Regenerating islet-derived protein 3α (Reg3α), a protein described as having protective effects against oxidative stress and anti-inflammatory activity, could participate in the control of glucose homeostasis and potentially be a new target of interest in the treatment of type 2 diabetes. To that end the recombinant human Reg3α
ABSTRACT: Radiation dosimetry is central to virtually all radiation safety applications, optimization, and research. It relates to various individuals and population groups and to miscellaneous exposure situations-including planned, existing, and emergency situations. The International Commission on Radiological Protection (ICRP) has developed a new computational framework for internal dose estima
Introduction: Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfusion practices in the ICU vary considerably. Therefore, we aim to provide contemporary epidemiologic
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 ×
This paper presents updated Monte Carlo configurations used to model the production of single electroweak vector bosons (W, Z/γ∗) in association with jets in proton-proton collisions for the ATLAS experiment at the Large Hadron Collider. Improvements pertaining to the electroweak input scheme, parton-shower splitting kernels and scale-setting scheme are shown for multi-jet merged configurations ac
City-wide climate adaptation for pluvial flood mitigation requires fast and reliable simulation tools. Considering the limitations of hydrodynamic models at city-scale simulations, data driven models have high potential in the development of surrogate tools. This study explores the Google DeepMind WaveNet™ model architecture to map hydrological response of catchments onto hydraulic parameters of t
In dry sandy soil, soil water is naturally redistributed by forces owing to matric and gravitational potential, and temperature gradients. Occurring shrub vegetation strongly influences these patterns by hydraulic redistribution within the soil. This means that plants can move water from moist to drier soil areas to extract nutrients from the drier soil and enhance nutrient uptake. This incorporat
An experimental investigation of surface pressure distributions (mean and r.m.s.) on two tubes (circular cylinders) mounted in an in-line or tandem arrangement was carried out in a low-speed, closed-circuit wind tunnel. The measurements were mainly performed at a subcritical Reynolds number, Re = 2·0 × 104, at three different turbulence intensities of the approaching cross-flow (0·1, 1·4 and 3·2%)
Hur ska vi komma till rätta med de stora utmaningar som den globala klimatkrisen ställer oss inför? Som individer kan vi alla bidra genom att sortera våra sopor, köra miljövänligt, eller kanske välja att ta cykeln till jobbet. Alla våra individuella bidrag räknas förstås. Men stora delar av vår mänskliga förmåga att förändra världen kommer inte från hur vi agerar var och en, utan från vår gemensamThe world is facing a climate crisis and established firms are set to play a critical role in the societal changes that are needed to defeat it. At the same time, digital technologies are advancing to enable many of the technological solutions that will be required. Together, these two trends, toward greater environmental sustainability and digitalized business, superficially suggest opportunities
Sustainability Science (SS) is known for aspiration to support societies towards ecologically sound trajectories – a fabulously reflexive, ultimately critical and deeply self-aware field with a diverse community of highly skilled and creative researchers of noble goals, rigorous training and active engagement with ‘real life’ (so we claim, or at least aspire for). We try hard to alter extinction o
The study aims to explore the increasingly relevant and theoretically underexplored field of ridesharing as a solution for first and last-mile transportation, its success factors and challenges, as well as the process of integrating ridesharing into a public transport network. It utilizes a business model innovation framework as the theoretical basis to explore success factors as well as challenge
Blockchain technology has in recent years gained significant momentum in a wide variety of industries. However, in the context of SMEs the IS body of research is lacking, both in terms of why SMEs should consider this new technology and the factors that affect a potential adop-tion. To explore this research gap, the authors derived a conceptual framework from the exist-ing literature along with el
This thesis examines the extent to which the French and Swiss models of corporate criminal liability may inform the development of proposals to extend the jurisdiction of the International Criminal Court (ICC) to encompass legal persons. The study employs a combination of doctrinal and comparative legal methodology, with particular emphasis on the legal models through which criminal liability may
Aedes aegypti is one of the most lethal disease vectors in modern history, spreading a majority of the deadliest diseases mediated by mosquitos. To try and combat this, mankind has, for a long time, tried to create repellents to keep the insects away. These repellents affect receptors in the mosquitos, keeping them at bay. One receptor that is highly expressed in the mosquito’s prey/host sensory o
This thesis explores the influence of the current economic paradigm, usually referred to as neoliberalism, on various aspects of life, thereby creating its own psychology. This psychology of neoliberalism, with a strong focus on competitiveness, individualism, and consumerism, creates intertwined dynamics for individuals, public institutions, and society and functions as the backbone of economic g
This project was completed in collaboration with the graph database company Neo4j with the aim of developing a new algorithm for automatic detection of software bugs that degrade system performance, commonly referred to as performance regressions in the industry. Due to the large number of benchmarks used to monitor different aspects of the product environment, a flexible and robust solution was n
