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Insulin resistance is a hallmark of type 2 diabetes, an increasingly common disorder. The cause of insulin resistance is supposedly failures in the processes used by insulin to signal to the interior of its target cells. These failing steps are still unknown, most probably because of incomplete knowledge of how the insulin signals are transmitted. Since insulin resistance is strongly linked to obe
The enzymatic degradation of plant polysaccharides is a process of fundamental importance in nature which involves a wide range of enzymes. In this work, the structure and function of hemicellulose-degrading enzymes was investigated. The focus was on a beta-mannanase (TrMan5A) produced by the filamentous fungus Trichoderma reesei. This enzyme is composed of a catalytic module and a carbohydrate-bi
The enzymatic degradation of wood polysaccharides such as cellulose and hemicellulose is an important process in nature. In addition, cellulases and hemicellulases can be used in industrial applications. Fuel ethanol can potentially be produced from wood by enzymatic hydrolysis of cellulose followed by yeast fermentation of the formed sugars. In this thesis, fungal glycoside hydrolases, cellulase
Popular Abstract in Swedish Våra kroppar är uppbyggda av celler. Dessa celler har olika funktioner beroende på var i kroppen de finns. Varje cell tar upp näring, omvandlar den till energi, och energin används för att cellen ska kunna fortleva och utöva specialiserade funktioner samt eventuellt reproducera sig. Kolhydrater är viktiga beståndsdelar i celler. De flesta av oss förknippar kolhydrater Proteoglycans (PGs) is a class of highly anionic macromolecules that consist of one or more linear polysaccharide chains (glycosaminoglycans, GAGs) covalently attached to a core protein. The biological functions of PGs are mainly due to the interactions of GAG chains with various protein ligands and regulatory factors, such as cytokines and growth factors. PGs and GAGs are critical for a diverse s
Among the formats introduced in Swedish radio in the 1930s, the theatre series about contemporary family life has turned out an exceptional survivor. The first family series, ”Ingenjör Björck med familj” (1936-1943), was followed by 22 related series during the rest of the 20th century, each cultivating its own intimate and ritual based bond with the listeners. The dissertation ”Höra hemma. Familj
Popular Abstract in Swedish Att vara kritisk till våra dagars medier är en självklarhet, medan 1800-talets presspionjärer däremot har fått behålla hjältestatusen. I "Pressen i provinsen" tecknas den moderna pressens genombrott dock som en utdragen och långtifrån entydig process. Från att på 1700-talet ha varit arenor där alla hade rätten att delta i det upplysta samtalet, blev tidningarna under böThis study treats ideas of how newspapers should be edited, from the middle of the 18th century to the middle of the 19th century. It deals both with notions of communication and how these were carried out. The empirical focus is on the Swedish province Östergötland and its two main cities, the ecclesiastical, military and administrative Linköping and the mercantile and financially important Norrk
Can an educational programme develop tomorrow’s leaders? Can the mindset and skill set found in successful leaders be taught and learnt in educational programmes? This paper presents a leadership program, a cross disciplinary master programme atLund University, Sweden. The students study technology and management, however, the programme’s unique value proposition lies in its focus on leadership.Th
This paper presents simulation results for a sliding-IF SiGe E-band transmitter circuit for the 81-86 GHz E-band. The circuit was designed in a SiGe process with fT = 200 GHz and uses a supply of 1.5 V. The low supply voltage eliminates the need for a dedicated transmitter voltage regulator. The carrier generation is based on a 28 GHz quadrature voltage oscillator (QVCO). Upconversion to 84 GHz is
Pharmacokinetic (PK) and pharmacodynamic (PD) properties for the selection of resistant pneumococci were studied by using three strains of the same serotype (6B) for mixed-culture infection in time-kill experiments in vitro and in three different animal models, the mouse peritonitis, the mouse thigh, and the rabbit tissue cage models. Treatment regimens with penicillin were designed to give a wide
Popular Abstract in Swedish Avhandlingen behandlar den kristna minoriteten Old Order Amish i USA ur ett ecklesiologiskt perspektiv. Genom att dels använda centrala begrepp som utgår från den undersökta gruppens egen religiösa vokabulär, dels några av de angreppssätt som är förhärskande inom det kyrkovetenskapliga studiet, framträder en fördjupad bild av amishfolkets insida. Hur uppfattar amish siThe thesis focuses on the way the Amish view their life and actions as Christians. With its basis in first-hand observations from the settlements of Dover (DE) and Lancaster (PA) the inquiry describes, analyzes and interprets the ecclesiastical life of the Old Order Amish from an ecclesiological viewpoint. Utilizing a specific model of analysis the dissertation examines the institutions (church/f
Popular Abstract in Swedish I Sverige bestäms fastighetsgränsers sträckningar i första hand av gränsmärken på marken, därefter av förrättningskartor och mätuppgifter. Under senare år har efterfrågan på digital fastighetsinformation ökat kraftigt, inte minst beträffande lägesnoggranna gränsdata i den nationella registerkartan. Den utvecklade positioneringstekniken med GPS utgör idag en grundförutsäIn Sweden, the course of a property boundary is first and foremost determined by boundary marks on the ground, and only secondly by cadastral survey plans and measurements. In recent years, the demand for digital property information has increased substantially, not least in respect of accurate boundary data in the national cadastral map. Today, well-established techniques such as GPS positioning
The present thesis addresses three issues related to proteinaceous films at solid/liquid interfaces: adsorption, lubrication and enzymatic interactions. Most of the work has been devoted to oral systems. In addition, gelatin has been investigated as a model protein. Salivary protein adsorption from human whole saliva (HWS) onto hydroxyapatite (HA) and silica has been characterised using ellipsome
Liberalisation and deregulation of public utility sectors has been introduced in several European countries. In 1994 Swedish municipalities were instructed to reorganise waste collection routines by enlarging the number of fractions to be able to reuse waste fractions in an environmental benign way. The public waste sector have to a considerable extent been diversified and deregulated. At the same
Popular Abstract in Swedish FN:s konferens om miljö och utveckling i Rio 1992 blev startpunkten för det lokala Agenda 21 arbetet och många svenska kommuner påbörjade lokala Agenda 21 processer under 1993. Avhandlingen syftar till att undersöka hur människor i fyra svenska kommuner upplever hållbar utveckling. Vad är viktigt för människor, och vem/vilka har ansvaret? Vidare analyseras individens käThe UN conference in Rio on Environment and Development in 1992 was the starting point for the local Agenda 21 work and several Swedish municipalities began their local Agenda 21 processes in 1993. This thesis aims at investigating how people perceive sustainable development in four Swedish municipalities. What is important and who is responsible? Individual influence and strategies for implementa
This work has focused on studying the in-cylinder pressure fluctuations caused by rapid HCCI combustion and determine what they consist of. Inhomogeneous autoignition sets up pressure waves traversing the combustion chamber. These pressure waves induce high gas velocities which causes increased heat transfer to the walls or in worst case engine damage. In order to study the pressure fluctuations a
Increased research is being driven by the automotive industry facing challenges, requiring to comply with both current and future emissions legislation, and to lower the fuel consumption. The reason for this legislation is to restrict the harmful pollution which every year causes 3.3 million premature deaths worldwide [1]. One factor that causes this pollution is NOx emissions. NOx emission legisl
BACKGROUND: Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by brain accumulation of aggregated amyloid-beta (Aβ) and alpha-synuclein (αSYN), respectively. In order to develop effective therapies, it is crucial to understand how the Aβ/αSYN aggregates can be cleared. Compelling data indicate that neuroinflammatory cells, including astrocytes and microglia, play a central ro
West African Sahelian and Sudanian ecosystems provide essential services to people and also play a significant role within the global carbon cycle. However, climate and land use are dynamically changing, and uncertainty remains with respect to how these changes will affect the potential of these regions to provide food and fodder resources or how they will affect the biosphere-atmosphere exchange
Climate change is exposing high-latitude systems to warming and a shift towards more shrub-dominated plant communities, resulting in increased leaf-litter inputs at the soil surface, and more labile root-derived organic matter (OM) input in the soil profile. Labile OM can stimulate the mineralization of soil organic matter (SOM); a phenomenon termed “priming.” In N-poor subarctic soils, it is hypo
Background: While recommendations for the optimal distribution of surgical services in high-income countries (HICs) exist, it is unclear how these translate to resource-limited settings. Given the significant shortage and maldistribution of surgical workforce and infrastructure in many low- and middle-income countries (LMICs), the optimal role of decentralization versus regionalization (centraliza
