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Abstract: Parkinson’s disease (PD) is a common neurodegenerative disorder. There is no proven protection, but many treatments can partially improve symptoms. The disease is caused by monogenetic mechanisms in very few cases, but for the majority of patients the etiology is unknown. Epidemiological studies have identified a potential role for inflammation. The thesis investigates inflammation and i

Popular Abstract in Swedish Runt 1750 upptäckte en tysk kemist vid namn Marggraf att det var möjligt att utvinna socker från betor. Ett par decennier senare började en av hans studenter, Archard, att selektera betor utifrån deras sockerhalt och öppnade också världens första sockerbetsfabrik år 1801. Mängden utvunnet socker per rot låg runt 4 %. Sedan dess har förädling och förbättrade jordbruksmetAround 1750 a German chemist discovered it to be possible to extract sugar crystals from beet juice. Since then, breeding and improved agricultural practices have increased the concentration of sucrose per root from around 4% to around 18%. Sugar content is still one of the most important characters in sugar beet breeding, but breeders of today are also faced with many more characters, many of a c

The early Middle Ages saw the formation of the three Nordic kingdoms of Sweden, Norway and Denmark, and at that time the area studied here constituted a border region between them. During the same period the Church was very active in the area: a bishopric was established and a large number of churches were built. This makes the area a particularly interesting one to study from the point of view of

Mitochondria play a pivotal role in eukaryotic energy metabolism. Like mitochondria across most eukaryotic species, plant mitochondria contain their own genomes and protein synthesis machinery. However, many plant mitochondrial key proteins and processes remain poorly understood. An example of this is the plant mitochondrial translation initiation. Although the cryoelectron microscopy (EM) structu

Visualisering är ett viktigt verktyg för förståelsen av olika fenomen inom mekaniken. Vid datormodellering med finita elementmetoden utförs flera steg som med hjälp av visualisering kan underlätta förståelse och inlärning. CALFEM är ett finita elementverktyg utvecklat vid LTH, med fokus på utbildning. För att verifiera att en finita elementmodell är korrekt utformad är det viktigt att kunna visualVisualizing results is an important part of Finite Element (FE) modeling. Many tools exist for visualizing these results, they are often part of complete software packages for FE analysis. These packages often rely on the user being familiar with FE analysis, making them unsuitable for use in teaching the FE Method. CALFEM (Computer Aided Learning of the Finite Element Method) is an FE toolbox de

During the Devonian, 377 Ma ago, the Earth was impacted by a large celestial body, striking ground in the Siljan area in Dalarna, Sweden. The impact created what is today the largest confirmed impact structure in western Europe. Since its formation, the structure has however been heavily eroded, leaving no trace of the original crater. Today, it is instead recognizable due to the central plateau a

The Swedish national library has collected nearly all Swedish printed materials for more than three centuries. Regarding digital material, the digital legal deposit act was enacted about nine years ago. According to the law, a selection of digital publications must be sent to the national library for preservation. The Swedish digital legal deposit act has been heavily criticized, mostly because it

This project is an investigation in atmosphere, and an attempt to create a new architectural idiom through the vernacular Japanese building style minka, the ambiance and context of the woods, and, importantly, by exploring whether it is possible to keep the crookedness from the first sketches throughout the whole process, into the completed building. Minka are traditional preindustrial homes for

The large-scale expansion of wind energy is an important element of the energy transition in Germany and a necessary tool to mitigate climate change. Yet, it is contested in many rural settings across the country. This thesis builds on the argument that rural areas are a crucial factor for the energy transition. They serve as the sites that host most of the infrastructure needed in the transition

Businesses today need to recognize that they have to be fast at realizing and exploiting new competitive advantages before the opportunity is lost. Instead of the traditional focus on price and quality, there is a shift towards the delivery of value to customers. This is strongly connected to the reduction of downtime of production and high reliability. Here the spare parts supply chain plays an i

Diabetic retinopathy is an ophthalmic complication of diabetes that currently affects 93 million people worldwide. Diabetic macular edema is a subtype of diabetic retinopathy that is characterized by leaking blood vessels in the central part of the retina, and it is a major cause of vision loss in individuals with diabetes. Screening for retinopathy is performed at regular intervals to identify su

We think much of a current consumption is strongly based on various types of loans every person should have an idea about how the loan approval mechanism works. Because everybody wants to know if they have a possibility of getting a loan approval, almost all banks’ web pages have a maximum loan calculator, which gives a client a maximum loan amount he/she could borrow at a current date given certa

This thesis contains four independent studies that analyze various aspects of the nexus of inequality, globalization, and health with the aim to build our knowledge so some of the empirical relationships connecting these three concepts. Using data on four welfare attributes in Zambian households, Chapter 2 explores three approaches to evaluate multidimensional inequality. The examination indicate

Popular Abstract in Swedish NÄR ÖRESUNDSBRON INVIGDES ÅR 2000 nådde förväntningarna på dansk-svensk integration sin kulmen. Prognoser och framtidsspekulationer haglade. Nyhetsbrev, reklamkampanjer, webbplatser och konferenser producerades på löpande band. Öresundsbron förenade Öresundsregionen. Öresundsregionen förenade skåningar och själlänningar. Tillsammans skulle de forna broderfolken skapa enThe Öresund Bridge between Denmark and Sweden was inaugurated in the year 2000, connecting the city of Malmö and the Danish capital Copenhagen. The bridge was an important move towards the visionary realisation of a transnational Öresund Region. In this dissertation the communicative aspects of the regional process are put in focus. The vision of the Öresund Region that developed during the 1990s

Phage display technology is a common approach for discovery of therapeutic antibodies. Drug candidates are typically isolated in two steps: First, a pool of antibodies is enriched through consecutive rounds of selection on a target antigen, and then individual clones are characterized in a screening procedure. When whole cells are used as targets, as in phenotypic discovery, the output phage pool

Popular Abstract in Swedish Magnetkameran är ett diagnostiskt instrument med vilket man kan ta skiktbilder av kroppen. Den började användas i sjukvården för drygt 20 år sedan och baseras på ett fysikaliskt fenomen som kallas för kärnmagnetisk resonans (MR). Detta innebär att vissa atomkärnor som placeras i ett starkt magnetfält kan avge en radiosignal när de utsätts för korta radiopulser. RadiosigContrast-enhanced magnetic resonance angiography (CE-MRA) is a diagnostic method for imaging of vascular structures based on nuclear magnetic resonance. Vascular enhancement is achieved by injection of a contrast medium (CM). Studies were performed using two different types of CM: conventional paramagnetic CM, and a new type of CM based on hyperpolarized (HP) nuclei. The effects of varying CM con

Continuous water-table (WT) measurements from peatlands are scarce and – if existing at all –very short. Consequently, proxy indicators are critically needed to simulate hydrological changes in peatlands over longer time periods. In this study, we demonstrate that tree-ring width (TRW) records of Scots pine (Pinus sylvestris L.) growing in the Čepkeliai peatland (southern Lithuania) can be used as

Paper for the Public and Social Innovation Conference (PUBSIC), Lillehammer University College, Lillehammer, Norway, 15-17 November, 2017Theme 7B: managing and evaluating sustainable innovation Katja Lindqvist & Ulrika Westrup, Department of Service Management and Service Studies, Lund University, Swedenkatja.lindqvist@ism.lu.se, ulrika.westrup@ism.lu.se In search of a model for sustainable inPaper for the Public and Social Innovation Conference (PUBSIC), Lillehammer University College, Lillehammer, Norway, 15-17 November, 2017 Theme 7B: managing and evaluating sustainable innovation In search of a model for sustainable innovation in welfare services Katja Lindqvist & Ulrika WestrupDepartment of Service Management and Service Studies, Lund University, Swedenkatja.lindqvist@ism.lu.s

This doctoral thesis examines the encounter between the dead and the living within 19th and 20th century landscape cemeteries. It shows how the relationship unfolds through the materiality and practices occurring within them.Landscape cemeteries were established from the late 18th century and with their garden-inspired design, location outside of the city and increasing secular administration were