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The observation that neural grafts can induce dyskinesias has severely hindered the development of a transplantation therapy for Parkinson's disease (PD). We addressed the hypothesis that inflammatory responses within and around an intrastriatal graft containing dopamine neurons can trigger dyskinetic behaviors. We subjected rats to unilateral nigrostriatal lesions with 6-hydroxydopamine (6-OHDA)
Finansieringen av nationella vetenskapliga tidskrifter har blivit ett lömskt problem eller ett wicked problem inte bara för historia utan för humaniora i stort. Liksom andra lömska problem utmärks denna fråga av att själva problembeskrivningen är föränderlig, definitionerna undflyende samt att problemet är sammanvävt med andra komplexa problemområden. För en långsiktig lösning är det därför nödvänThe question of how to fund Swedish academic journals such as Scandia has become a wicked problem, not only for history but also for the humanities as a whole. This issue is confounded by the difficulty in terms of categorizing these journals and their funding needs and further complicated by the global movement towards open access. For the humanities, the issue of how to fund these journals is of
Amyloid formation is linked to devastating neurodegenerative diseases, motivating detailed studies of the mechanisms of amyloid formation. For Aβ, the peptide associated with Alzheimer’s disease, the mechanism and rate of aggregation have been established for a range of variants and conditions in vitro and in bodily fluids. A key outstanding question is how the relative stabilities of monomers, fi
Resilience in tourism studies has mainly departed from a socio-ecological system-theory approach and has developed knowledge in relation to different tourism contexts. This approach has consequences for the conceptualization of resilience and sets limits. Calls for theory development on resilience see a need to take account of, for instance, politics and power relations, and conflicts over resourc
Wind power is seen by many observers as an important part of the transition to a sustainable energy system, since it does not contribute to the environmental problems connected with dominating energy forms such as fossil fuel, nuclear power and large-scale hydro power. At the same time wind power has some characteristics that makes it a special challenge for land use planning. In Sweden, where win
Popular Abstract in Swedish Vanlig bagerijäst, Saccharomyces cerevisiae, används i storskalig etanol framställning från majs och sockerrör. Användandet av dessa råvaror för etanolproduktion konkurerar dock med framställning av spannmål för föda och djurhushållning. Den här avhandlingen har syftat till att få bagerijäst att använda sockerarten xylos, som finns i stora halter i restprodukter från skBaker’s yeast, Saccharomyces cerevisae, has been engineered to utilize the pentose sugar xylose present in lignocellulose biomass for the production of ethanol. Currently ethanol production from xylose is slow which limits the implementation of said strains in industrial production. This thesis describes the investigation of several metabolic aspects that control the rate of xylose utilization by
Purpose: Sick leave and unemployment are highly prevalent among people with affective disorders. Their depression severity is disabling and inversely related to having employment. No evidence-based vocational rehabilitation exists for this target group. Knowledge is therefore needed to understand the psychosocial factors that affect depression severity in order to develop new rehabilitation interv
The present thesis explores Japanese imperative constructions from a general linguistic perspective, as well as examining the imperative as a cross-linguistic object of study. On the definitional side, a terminological apparatus for the description and analysis of imperatives and directives is presented. It includes the proposal that the range of conventional directive strategies in a language be
Objective: To evaluate the effect of dosage on the metabolic response to vegetables added to a mixed lunch meal, and to relate the amounts to the tripartite plate model. Carrots were chosen as an example, and the carrots were blanched, frozen and boiled to include possible effects of processing and cooking. The effects of carrots steeped in lactic acid, as produced at fermentation, were also studi
Catalytic incineration is one of the methods to reduce the emissions of CO and VOCs. Low operation temperature and low catalyst cost are essential parameters for catalytic incinerators. Pt/Al2O3 catalysts are frequently used today, but the cheaper metal oxide catalysts can be very competitive if comparable overall activity is obtained. This thesis concerns how it is possible to decrease the operat
This doctoral thesis has its theoretical origin in the notion that the information flow between management teams, financial analysts and investors is especially exposed to information asymmetry when knowledge-intense companies are concerned. Information asymmetry may aggravate agency problems and risk causing an impairment of the efficient allocation of capital on the stock market. Therefore, the
Vascular smooth muscle cells (VSMCs) in the intact vascular wall are differentiated for contraction, whereas the response to vascular injury involves transition towards a synthetic phenotype, with increased tendency for proliferation. Platelet-derived growth factor (PDGF) is thought to be important for this process. We investigated expression and functional coupling of PDGF receptors (PDGFRs) alph
The concentration of cholesterol in cell membranes affects membrane fluidity and thickness, and might regulate different processes such as the formation of lipid rafts. Since interpreting experimental data from biological membranes is rather intricate, investigations on simple models with biological relevance are necessary to understand the natural systems. We study the effect of cholesterol on th
Oxy-fuel combustion is one of the proposed technologies which have the potential to achieve zero CO2 emission. Strontium cobalt based perovskite oxygen carriers are promising materials for air separation with a high selectively for oxygen. And these perovskites can produce an oxygen enriched carbon dioxide stream for an oxy-fuel combustion process. The relatively low oxygen production yield may be
Popular Abstract in Swedish Populärvetenskaplig svensk sammanfattning Har allvarliga infektioner orsakade av bakterien Haemophilus influenzae försvunnit? En undertyp av H. influenzae, typ b (Hib), var tidigare en fruktad orsak till struplocksinflammation, hjärnhinneinflammation och svår blodförgiftning hos små barn. Problemet var så stort att allmän vaccination mot Hib infördes i många länder i böWhat is the current status of Haemophilus influenzae as an agent of invasive infection in Sweden? H. influenzae type b (Hib) used to be a common cause of meningitis, epiglottitis and severe sepsis in young children. In the late 1980’s an effective conjugated vaccine against Hib was developed and a dramatic fall in Hib incidence was observed in countries that implemented vaccination. This includes
The modernisation of Swedish households during the twentieth century prompted a considerable productivity growth in household production. This paper examines the association between this process and the allocation of female time in Swedish urban households during the period 1920-1990. Estimates presented in the paper suggest a minimum potential time reduction for a fixed volume of routine househol
AIM AND OBJECTIVE: To describe the study design of a randomised controlled trial with the aim of comparing two different regimes for children with newly diagnosed type 1 diabetes; hospital-based care and hospital-based home care. BACKGROUND: Procedures for hospital admission and sojourn in connection with diagnose vary greatly worldwide and the existing evidence is insufficient to allow for any c
The study examines a hitherto neglected genre in Swedish poetry of the 17th and 18th centuries: the animal epitaph. From 1670 to 1760 a considerable number of such poems were composed by several of the leading poets of the day. Besides tracing the history of the genre back to its origins in the ancient Greek epigram, I am chiefly concerned with the functions that the writing of such epigrams had i
This thesis presents a number of results and algorithms for the numerical solution of problems in geometric computer vision. In geometric computer vision one tries to extract geometric information about the world and the observer from a sequence of images. Estimation of scene structure and camera motion using only image data has been one of the central themes of research in photogrammetry, geodesy
