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The pulmonary route has emerged as a promising strategy for delivering protein therapeutics, particularly for patients suffering from respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and pulmonary infections. This project investigated the effect of operating parameters of a laboratory spray dryer on the characteristics of powders composed of Bovine Serum Albumin
Introduction: Many countries in the world are still facing high maternal mortality rates and women still die due to preventable pregnancy- and birth-related causes. This could be prevented with an improvement in the quality of care and yet many countries, especially in the rural areas, have challenges in doing so. In order to understand why is care given in certain way, more qualitative studies ne
5-Hydroxymethylfurfural (HMF) is a versatile bio-based platform chemical that can substitute fossil-derived intermediates in polymers, solvents, and fuels, thereby contributing to a fossil-free chemical industry. While first-generation feedstocks such as high-fructose corn syrup have been widely studied, their use raises concerns about competition with food supply. In contrast, second-generation r
Cameras mounted on boats and in other similar environments can be hard to use if waves and wind cause unwanted motions of the camera which disturbs the desired image. However, this is a problem that can be fixed by applying mechanical image stabilization which is the goal of this thesis. The mechanical image stabilization is achieved by controlling two stepper motors in a pan-tilt-zoom (PTZ) camer
Popular Abstract in Swedish I allt större grad har effektivitetsbegreppet kommit i fokus i samhällsomvandlingen. I huvudsak utgår vi från att effektivitet i första hand är liktydigt med ekonomisk effektivitet. Existensen av en slags övergripande, ekonomisk "rationalitet", tas för given och har närmast karaktären av naturlag eller central, samhällelig grundbult. Under det senaste decenniet har omfaThe study takes as its starting point the far-reaching organizational changes that have occurred within the public sector in Sweden, particularly the public health care sector, during the last decade. The aim of achieving efficacy has been an important driving force in these processes, which often concern mergers or reductions in personnel that are regarded as a route to success. Paradoxically, Sw
Popular Abstract in Swedish Intestinal ischemi/reperfusion (I/R) är ett potentiellt mycket allvarligt tillstånd som kan bero dels på direkt ocklusion av mesenteriella kärl, men även vara sekundärt till andra tillstånd med nedsatt visceral cirkulation, som exempelvis chock eller akut pankreatit. Trots korrekt och även initialt framgångsrik behandling av den bakomliggande orsaken till I/R-tillståndeIntestinal ischemia and reperfusion (I/R) is a potentially life-threatening condition, sometimes leading to a systemic inflammatory response and the potential development of the multiple organ dysfunction syndrome. The overall aim of the thesis was to study the effects of intestinal I/R on pulmonary function with special emphasis on removal of excess alveolar fluid, pulmonary endothelial barrier p
The EU governance of food safety and GM food and feed has gone through significant changes since the BSE crisis and food scares during the 1990s. This work focuses on one particular new feature; the role of stakeholders representing the food chain: biotech associations, farmer organizations, food and feed processors, consumer organizations and environmental NGOs. These stakeholders are not merely
This thesis reports a study involving the use of Halomonas boliviensis, a moderate halophile, for production of biopolyester poly(3-hydroxybutyrate) (PHB) and compatible solutes ectoine and hydroxyectoine through high cell-density cultivation comprising fed-batch cultures. PHB is a biodegradable plastic produced by bacteria as energy reserve and can potentially be used as a replacement of fossil b
Analysis methods are currently being miniaturized in order to save time and money while achieving higher sensitivities. The ultimate goal is to create a lab-on-a-chip where all analysis steps and instruments can be automated and integrated into a single chip. In order to perform cellassays and microparticle based bioassays on chip, methods to manipulate particles and cells in microsystems are desi
The N-terminal RNA binding domain of U1A has been shown to fold in a two-state process without accumulating any intermediates. U1A has a symmetrically curved chevron plot which seems to result mainly from changes of the transition state. At low concentrations of denaturant the transition state occurs early in the folding reaction, whereas at high denaturant concentration it moves close to the nati
Sealings are an important part in the industrial robot. One important property of the seal is to keep all particles and fluids from the outside, away from the important components inside the robot. Another important property is to keep the oil and grease inside the robot, and prevent leakage. The seal also prevent leakage inside the industrial robot and reduces the risks of sensitive components to
Complement C3 in control: Pulling the strings behind β-cells in the diabetes scene Complement protein C3 has been discovered to be expressed in the pancreatic β-cells and play crucial roles in their biology regardless of the Immune responses. In my project, I looked into further uncovering the novel roles and intracellular processing of this protein in the β-cells. Complement system is a well-st
Syfte & mål: Syftet med detta examensarbete är att få insyn i hur hållbara stadsutvecklingsstrategier genom implementeringar av olika certifieringar och strategier kan påverka mindre samhällen. Där undersöker man det rådande läget gällande den hållbara stadsutvecklingen i tätorterna samt hur olika utvecklingsstrategier på internationell, nationell och regional nivå kan påverka mindre samhällenAim and purpose: The purpose of this thesis is to gain insight into how sustainable urban development strategies through the implementation of various certifications and strategies can affect small towns. It examines the current situation regarding sustainable urban development in small towns and how different development strategies at the international, national and regional levels can affect sma
Directed relation graph with error propagation (DRGEP) method combined with extensive validation for 0D, 1D and 2D CFD modeling supported by sensitivity and Rate-Of-Production (ROP) analyses are implemented for comparative study of detailed and reduced kinetic mechanisms for CH 4 + H 2 combustion. To this end, two detailed kinetic mechanisms, namely AramcoMech 2.0 and recently updated Konnov me
The transition towards low-carbon energy systems undeniably requires a strong scale-up in the diffusion of renewable energy technologies globally. Given its theoretical and techno-economic potential, solar photovoltaics (PV) is considered an important option. The envisioned scale-up of the use of solar PV, however, requires an in-depth and system-oriented perspective on structures and processes re
Quantitative nuclear medicine imaging is an increasingly important frontier. In order to achieve quantitative imaging, various interactions of photons with matter have to be modeled and compensated. Although correction for photon attenuation has been addressed by including x-ray CT scans (accurate), correction for Compton scatter remains an open issue. The inclusion of scattered photons within the
Leading philosophical accounts of joint activity, such as Michael Bratman’s account of ‘shared intentional activity’, take joint activity to be the outcome of two or more agents having a ‘shared intention’, where this is a certain pattern of mutually known prior intentions (plans) that are directed toward a common goal. With Bratman’s account as a foil, I address two lacunas that are relatively un
Klimatförändringarna kommer att påverka ekosystem och samhällen över hela världen. Det är ett problem som kräver drastiska och omedelbara förändringar av vårt sätt att leva och av våra samhällsstrukturer, och därmed politiskt engagemang av aldrig tidigare skådat slag. Under de senaste 30 åren, sedan bildandet av Förenta Nationernas ramkonvention om klimatförändringar (Klimatkonventionen; UNFCCC) åThe rise of climate change as an issue of global concern has rested on scientific representation and understanding of the causes and impacts of, and responses to climatic change. The Intergovernmental Panel on Climate Change (IPCC), in particular, has been central to how climate change has become known as a global political problem. This thesis aims to critically examine the production, negotiatio
The Bogong moth (Agrotis infusa) is a small, night-active Australian moth that has a remarkable lifestyle. Afterhatching from its pupa in spring, it migrates over 1000 km to the Australian Alps, where it spends the summer incool alpine caves. In the beginning of autumn, the moths emerge from the caves and fly back to their breedinggrounds, where they mate, lay eggs, and die. The following year, a
BackgroundDense Non Aqueous Phase Liquids (DNAPL) such as chlorinated solvents are common pollutants stemming from different types of industries including dry cleaning facilities, and reports on cases showing serious risk to soil and ground water are frequent on a global scale. DNAPLs are especially problematic as they are denser than water and move down through the groundwater, not always followi
