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Background: Treatment seeking for gambling disorder is known to be low and there has been a lack of longitudinal research regarding treatment opportunities. The present study aimed to assess possible changes in treatment uptake after a formal introduction of gambling disorder in social services and health care legislations, by using register data, including patient characteristics with respect to

RNA therapeutics is a new class of targeted therapies that has entered the clinic in the last decade. Lipid nanoparticles (LNPs) and conjugation to N-acetylgalactosamine have proven to be efficient strategies to deliver RNA payload to the liver. Successful delivery of sensitive RNA molecules to other target tissues or tumors remains one of the key challenges with the development of new RNA-based t

BACKGROUND: Post-partum hemorrhage (PPH) is the major cause of maternal mortality in Ghana and worldwide. Active management of the third stage of labor (AMTSL) is a globally recommended three-step method that in clinical trials has been proven effective in prevention of PPH. The AMTSL guidelines were introduced in 2003, modified in 2006, and has been part of the national guidelines in Ghana since

The Major Intrinsic Proteins, MIPs, constitute a large, ancient superfamily of membrane proteins that are found in all kingdoms of life. Most MIPs facilitate passive diffusion of water across biological membranes (aquaporins), although many channels are also permeable for glycerol and other small uncharged solutes, (aquaglyceroporins). Other substrates reported for specific MIPs are anions, carbon

Popular Abstract in Swedish Denna avhandling fokuserar en religiös aktör i det civila samhället under en konfliktfylld tid. Judiska, muslimska och kristna barn studerade tillsammans i anglikanska missionsskolor under den brittiska mandattiden i Palestina. Jerusalem var då etniskt och religiöst delat. Det anglikanska utbildningsprojektet var en del av den Anglikanska kyrkans försök att främja konflThis thesis concerns a religious actor in the civil society in times of violent conflict. During the British Mandate period in Palestine, Jewish, Muslim and Christian children studied together at Anglican missionary schools. At this time Jerusalem bore all the imprints of ethnic and religious separation and division. The Anglican educational project became part of the efforts made by the Anglican

Context. The structures of the outer atmospheres of red giants are very complex. Recent interpretations of a range of different observations have led to contradictory views of these regions. It is clear, however, that classical model photospheres are inadequate to describe the nature of the outer atmospheres. The notion of large optically thick molecular spheres around the stars (MOLspheres) has b

Optical spectroscopy has been used as a supplement to conventional techniques for analyzing and diagnosing cancer in many human organs. Because ocular tumors may be characterized by their different melanin content, we investigated the feasibility of using transscleral visible/near-infrared spectroscopy (Vis/NIRS) to estimate the quantity of melanin in a novel uveal melanoma phantom of ex vivo porc

Protein structure and stability are inherent in the amino acid sequence and governed by non-covalent interactions. The cooperation between forces is, however, perplexing and not well understood. In order to elucidate and predict protein folding and stability, detailed studies of non-covalent interactions are required. Presented in this thesis are detailed studies on electrostatic interactions in

Popular Abstract in Swedish Radiojodbehandling av sköldkörteln är den vanligaste radiofarmakaterapin. För att beräkna aktiviteten 131I som krävs för att ge en viss stråldos till sköldkörteln behöver sköldkörtelns massa och den individuella biokinetiken bestämmas. Biokinetiken består vanligtvis av det individuella upptaget av jodid och den biologiska halveringstiden av jod i sköldkörteln. Den bioloRadioiodine therapy of hyperthyroidism is the most frequently performed radiopharmaceutical therapy. To calculate the activity of 131-I to be administered for giving a certain absorbed dose to the thyroid, the mass of the thyroid and the individual biokinetic data, normally in the form of uptake and biologic half-time, have to be determined. The biologic half-time is estimated from several uptake

The way in which the cortical cytoskeleton associates to the plasma membrane (PM) must be elucidated to understand the structural dynamics of many processes in the plant cell. In the present study, isolated cauliflower (Brassica oleracea L.) PM vesicles were used to characterize membrane/cytoskeleton interactions. Both actin and tubulin were shown to copurify with PM vesicles and this copurificati

Human activity is constantly causing environmental problems due to production and release of numerous chemicals. A group of compounds of special concern is persistent organic pollutants (POP). These toxic, lipophilic chemicals have a high chemical and biological stability, and tend to accumulate in the lipid phase of living organisms. A major sink for POPs are sediments, and consequently these are

Popular Abstract in Uncoded languages [abstract language: Dutch] [Figure 5.1 can be found in the uploaded files] Populair wetenschappelijke samenvatting --- Van Hipparchus tot Gaia --- Sterrenkunde is waarschijnlijk één van de oudst bekende wetenschappen van de mensheid. Prehistorische culturen waren al gefascineerd door de manier waarop de sterren, planeten en kometen zich aan de hemel voortbewThe space astrometry mission Gaia, planned for launch in 2013 by the European Space Agency (ESA), will provide the most comprehensive and accurate catalogue of astrometric data for galactic and astrophysical research in the coming decades. It will observe roughly one billion stars, quasars and other point like objects for which the five astrometric parameters (position, parallax and proper motion)

The thesis focuses on the numerical simulation of the flow field in gas turbine burners. Due to tougher and tougher requirements on low levels of emission of pollutants there is a need for new combustion technologies. In gas turbines one method to attain low pollutant levels is the use of lean premixed combustion. However, in lean combustion, problems related to the flame stability can arise. Swi

This thesis summarizes experimental work in which the powerful Ti:sapphire lasers at the High Power Laser Facility at the Lund Laser Centre have been employed to investigate laser-produced X-rays and relativistic channelling. These lasers produce short pulses, of the order of 50 fs, with energies ranging from 1 mJ to 1 J. Thus, the peak powers reach several terawatts and with the most powerful las

Variations in molybdenum isotopic composition, spanning the range of similar to 2.3 parts per thousand in the terms of Mo-97/Mo-95 ratio, have been measured in sediment cores from three lakes in northern Sweden and north-western Russia. These variations have been produced by both isotopically variable input of Mo into the lakes due to Mo isotopic heterogeneity of bedrock in the drainage basins and

Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both

Popular Abstract in Swedish Utveckling av AMS-tekniken och tillämpningar på 3H och 59Ni mätningar Traditionellt mäter man radioaktivitet genom att registrera den utsända strålningen från sönderfallande kärnor. Denna sönderfallsmätning fungerar oftast bra så länge halveringstiden (den tid det tar för hälften av kärnorna att sönderfalla) är kort nog samt då man har tillräckligt mycket material. MetAccelerator mass spectrometry (AMS) is a highly sensitive technique for counting atoms. Its main advantage in comparison with radiometric methods is the smaller amount of sample required (by a factor of a thousand). The method has a high efficiency and requires only some ten mg of sample material. The radioisotope 59Ni is of great importance in nuclear waste management in the nuclear industry. Thi

Popular Abstract in Swedish Avhandlingen handlar om utvecklingsarbete av institutionsvård för ungdomar. Årligen bevil-jar Statens institutionsstyrelse ett tiotal miljoner kronor till utvecklingsprojekt för sina institu-tioner. Sedan i mitten av 1990-talet har stora satsningar gjorts för att utveckla institutionernas kompetens i familj- och nätverksarbete. Syftet med avhandlingen är att undersöka i

Background: Walking and cycling to school could be an important regular source of physical activity in growing children. The aim of this 12 months prospective observational study was thus to evaluate the effect of self-transportation to school on bone mineral accrual and gain in bone width in pre-pubertal children, both traits independently contributing to bone strength. Methods: Ninety-seven girl