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Effects of pharmaceutical excipients on the chemical stability of therapeutic proteins in a parenteral formulation

Proteins and peptides are widely used for the prevention, management, and cure of various illnesses. This vast therapeutic potential represents a significant portion of the pharmaceutical industry in the form of vaccines, antibodies, enzymes, and other protein-based therapeutics. During the drug development process, these proteins/peptides are affected by various environmental factors such as temp

Internet of Things och samtycke enligt dataskyddsförordningen – En undersökning om hur väl dataskyddsförordningens reglering, särskilt gällande samtycke, är anpassad för Internet of Things

Internet of Things (IoT), det vill säga fysiska objekt med inbyggd elektronik som kan kopplas upp mot internet och styras eller utbyta data över nätet, har idag blivit en självklar del i många personers vardag. Det kan vara allt från hälsoarmband och kylskåp, till glödlampor och termostater. Som förutspås har vi dock ännu inte sett det stora genombrottet för denna teknik och vad den kan komma att The Internet of Things (IoT), i.e. physical objects with embedded electronics that can be connected to the internet and be controlled or exchange data over the network, has become an integral part of many people's daily lives. IoT devices can be anything from fitness trackers and refrigerators to light bulbs and thermostats. However, as is being predicted, we have yet to see the major breakthr

Den Vanvördiga Paradoxen: Unga vuxna konsumenters uppfattning av ett vanvördigt tonfall på varumärkens sociala medier

Title: The Irreverent Paradox: Young adult consumers' perceptions of an irreverent tone on brands' social media Seminar date: May 30th 2024 Course: FEKH29, Degree Project Undergraduate level in marketing, 15 UPC Authors: Joel Baumann & Douglas Cederlund Advisor/s: Nikos Macheridis Key words: Social media marketing; Tone of voice; Irreverence; Consumer experiences; Authenticity Research

Mellan liv och rätt - En analys av den rättsliga regleringen av sen selektiv fosterreduktion i Sverige

I samband med graviditeter förekommer flerbörd, vilket leder till ökade medicinska risker för både fostren och den gravida kvinnan. Det gör att det kan finnas anledning att reducera antalet foster. Fosterreduktion kan bl.a. göra att möjligheterna att överleva ökar för kvarvarande foster. Trots att fosterreduktion har visat sig vara ett ingrepp som minskar riskerna för både foster och modern så är Pregnancies are in some cases associated with multiple pregnancies, which is leading to increased medical risks for the fetus and the pregnant woman. This means that there may be a reason to reduce the number of fetuses. Among other things, fetal reduction can increase the chances of survival for the re-maining fetuses. Although fetal reduction has been shown to be a procedure that reduces the ris

Mapping flood-prone areas in Bangladesh and assess how climate change will impact future flood risks

Bangladesh faces recurrent and severe flooding due to its low-lying topography and intense monsoon climate, making it one of the most flood-prone countries in the world. These floods pose significant threats to human life, infrastructure, and economic stability which is projected to intensify under future climate change scenarios. This thesis presents a flood susceptibility assessment using the An

'Squaring the circle': A case study of justification vis-à-vis financiers in cultural industries

In light of the recent austerity measures affecting cultural policy in several Western countries, this thesis aims to investigate the values mobilised by a cultural festival in Cologne, Germany, to justify its activities to financiers. A qualitative case study approach was adopted, involving interviews with festival representatives and document analysis of funding applications. Drawing on Boltansk

Alloying of Lead-Free Layered Double Perovskite Nanocrystals for Tailoring Structural and Optoelectronic Properties

The race towards sustainability In a rapidly advancing society, energy consumption has increased in tandem with the rise of digitalisation and modern lifestyles. However, the recent situation of producing energy is to use finite resources such as fossil fuels. Furthermore, the use of said resource has side effects that are highly undesirable, as it is a huge contributor towards global warming. Alt

Professional Emotions in Court : A Sociological Perspective

Professional Emotions in Court examines the paramount role of emotions in the legal professions and in the functioning of the democratic judicial system. Based on extensive interview and observation data in Sweden, the authors highlight the silenced background emotions and the tacitly habituated emotion management in the daily work at courts and prosecution offices. Following participants ‘backstaProfessional Emotions in Court examines the paramount role of emotions in the legal professions and in the functioning of the democratic judicial system. Based on extensive interview and observation data in Sweden, the authors highlight the silenced background emotions and the tacitly habituated emotion management in the daily work at courts and prosecution offices. Following participants ‘backsta

Gaia DR3 reveals the complex dynamical evolution within star clusters

Context. Star clusters, composed of stars born from the same molecular cloud, serve as invaluable natural laboratories for understanding the fundamental processes governing stellar formation and evolution. Aims. This study aims to investigate correlations between the Mean Interdistance (Di), Mean Closest Interdistance (Dc) and Median Weighted Central Interdistance (Dcc) with the age of star cluste

Observation of thickness-independent ultrafast relaxation times in MPCVD few-layer graphene

Graphene presents unique optoelectronic properties, making it attractive for the development of a wide range of new and advanced technological applications such as high-speed photodetectors and all-optical modulators. The study and control of the generated carriers in graphene, namely their ultrafast relaxation dynamics, are of great importance for these applications. Here, we report the ultrafast

Prevalence and Determinants of the Composite Index of Anthropometric Failure in Children Under Five Years in Bangladesh: Insights From a National Survey

ABSTRACT Child undernutrition remains a significant public health issue in Bangladesh, with high rates of stunting, wasting, and underweight. The Composite Index of Anthropometric Failure (CIAF) offers a comprehensive tool for assessing overall undernutrition. Although previous studies in Bangladesh have utilized CIAF, they have relied on older datasets. Estimating the current status is essential

Stakeholders' Perspectives on the Landscape of Peer Support in Swedish Mental Health Services : A Qualitative Study

The integration of peer support workers (PSW) into the mental health services workforce has offered additional avenues to strengthen service provision. In Sweden, the availability of peer support workers has grown significantly over the past decade, yet there has been insufficient investigation into their organization and implementation. Consequently, there is a growing need for further research i

High-Resolution 3D Turbo Spin-Echo Wrist MRI at 7T Accelerated by Compressed Sensing

This study aimed to obtain high-resolution 3D isotropic turbo spin-echo (TSE) wrist MRI acquisitions at 7T, with and without fat suppression, facilitated by compressed-sensing (CS) acceleration. In 16 healthy subjects, fat-suppressed (FS) and nonfat-suppressed (NFS) TSE wrist images were obtained. The protocol consisted of a SENSE-accelerated scan, with an isotropic voxel size of 0.45 mm and acqui

Genetic, morphological, and feather isotope variation of migratory willow warblers show gradual divergence in a ring.

Abstract The circular distribution of the willow warbler Phylloscopus trochilus around the Baltic Sea shares many features with the classic examples of ring species; however, the system is much younger. It has previously been shown that a secondary contact zone is located in central Scandinavia, where there are narrow clines for several morphological traits coincident with a migratory divide. Here

A virtual-accelerator-based verification of a Monte Carlo dose calculation algorithm for electron beam treatment planning in clinical situations.

Background and purpose The introduction of Monte Carlo (MC) techniques for treatment planning and also for verification purposes will have considerable impact on the radiation therapy planning process. The aim of this work was to use a virtual accelerator to study the performance of a MC-based electron dose calculation algorithm, implemented in a commercial treatment planning system. Methods The

Contrasting Approaches in the Implementation of GRADE Methodology in Guidelines for Haemophilia and Von Willebrand Disease

Introduction: The 2024 ISTH clinical practice guideline (CPG) for treatment of congenital haemophilia, the NBDF-McMaster Guideline on Care Models for Haemophilia Management, and ASH ISTH NBDF WFH guidelines on the diagnosis and management of VWD all utilised GRADE methodology. Aim: Discuss missed opportunities and the methodological approach of the ISTH Guideline in contrast to how GRADE was previ

A century of theories of balancing selection

Traits that affect organismal fitness are often very genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature (after all) “selects” the best genotypes at the expense of those that fall short. Explaining the extensive genetic variation of fitness-related traits is thus a longstanding puzzle in evolutionary biol

Input rates, decay losses and accumulation rates of carbon in bogs during the last millennium: internal processes and environmental changes

In peatlands the balance between litter input and decay loss in the oxic acrotelm determines the rate of carbon input to the anoxic catotelm with carbon lost at very slow rate. In the acrotelm the C/N-quotient decreases with depth and indicates the loss of carbon from the acrotelm. On one boreo-nemoral and three subalpine ombrotrophic bogs in Sweden the carbon losses in the acrotelm plus the appar

A method to identify investigative blind spots (MIBS) : Addressing blunt-end factors of ultra-safe organizations’ investigation-work-as-done

Ultra-safe organizations, such as Air Navigation Service Providers (ANSPs), have extensive safety management organizations and generally excellent safety records with very few serious incidents and accidents. This development has been supported by increasingly advanced and effective methods. However, recent research has uncovered how the application of even advanced incident investigation methods