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Polymeric multilayer capsules formed by the layer-by-layer (LbL) technique are interesting candidates for the purposes of storage, encapsulation, and release of drugs and biomolecules for pharmaceutical and biomedical applications. In the current study, cellulose-based core-shell particles were developed via the LbL technique alternating two cellulose derivatives, anionic carboxymethyl-cellulose (
Synaptic transmission is mediated by neurotransmitters that are stored in synaptic vesicles (SV) and released at the synaptic active zone (AZ). While in recent years major progress has been made in unraveling the molecular machinery responsible for SV docking, fusion and exocytosis, the mechanisms governing AZ protein and SV trafficking through axons still remain unclear. Here, we performed stop-f
Although spatial resolution in fluorescence microscopy and related fields has advanced to the nanometer scale, time resolution has remained essentially unchanged and is set by the camera system’s imaging time. Yet adequate time resolution is crucial for information acquisition about, for instance, dynamical processes in cells. This acquisition typically proceeds by analyzing biomolecular trajector
A numerical and experimental study of partial admission in a low reaction two-stage axial air test turbine is performed in this paper. In order to model one part load configuration, corresponding to zero flow in one of the admission arcs, the inlet was blocked at one segmental arc, at the leading edge of the first stage guide vanes. Due to the unsymmetrical geometry, the full annulus of the turbin
Enzymes are dynamic entities, and their conformational dynamics are intimately linked to their function and evolvability. In this context, protein tyrosine phosphatases (PTPs) are an excellent model system to probe the role of conformational dynamics in enzyme function and evolution. They are a genetically diverse family of enzymes, with a highly conserved catalytic domain, identical catalytic mec
Integrated Assessment (IA) models aim at providing information- and decision-support to complex problems. This paper argues that uncertainty analysis in IA models should be user-driven in order to strengthen science–policy interaction. We suggest an approach to uncertainty analysis that starts with investigating model users’ demands for uncertainty information. These demands are called “uncertaint
The thickening effect of a hydrophobically modified polymer in an aqueous solution is dependent on intermolecular hydrophobic associations, and if the polymer concentration is significantly above the overlap concentration also on chain entanglements. In this investigation we have added different cyclodextrins (CD) in order to decouple hydrophobic polymer-polymer associations via inclusion complex
Background: It is highly important in nursing care for persons with stroke to screen for, assess and manage eating difficulties. The impact on eating after stroke can be of different types, comprising dysphagia as well as eating difficulties in a larger perspective. Eating difficulties can cause complications such as malnutrition, dehydration, aspiration, suffocation, pneumonia and death. There is
The action of three matrix metalloproteinases (MMPs), 72- and 95-kDa gelatinases (MMP-2 and MMP-9) and PUMP (MMP-7), and a cysteine proteinase, cathepsin B, were investigated on aggrecan the major proteoglycan of cartilage. All the enzymes cleaved aggrecan although the activity of the 95-kDa gelatinase was very low. Specific cleavage sites were investigated following incubation with a purified agg
For years, safety improvements have been made by evaluating incident reports and analyzing errors and violations. Current developments in safety science, however, challenge the idea that safety can meaning-fully be be seen as the absence of errors or other negatives. Instead, the question becomes whether a company is aware of positive ways in which people, at all level of the organisation, contrib
Background: Monoclonal antibodies (mAb) are important tools in the management of tumor disease, and the discovery of antibodies with both specific cancer cell targeting and capacity to enter the cells by internalization are critical to improve the therapeutic efficacy. Method: Antibody cancer cell targeting and internalization properties of fluoroscein-conjugated mAb made against Lewis Y (BR96) we
The visual content of out-of-body experiences (OBEs) has received little attention but a number of theories of OBEs include implicit predictions regarding the determinants of this phenomenological feature. Hypnagogic imagery and unusual sleep experiences, weak synaesthesia and preference for employing object and spatial visual imagic cognitive styles were psychometrically measured along with the i
Proteins can adjust their structure and function in response to shifting environments. Functional diversity is created not only by the sequence but by changes in tertiary structure. Here we present evidence that lipid cofactors may enable otherwise unstable protein folding variants to maintain their conformation and to form novel, biologically active complexes. We have identified unsaturated C18 f
The crystallization Process in aqueous solutions of the drug bicalutamide and the effect of the polymer polyvinylpyrrolidone (PVP) have been studied. Results showed that PVP decreased the crystallization Fate significantly in a system with PVP concentrations as low as 0.01% (w/w), without changing the polymorph formed. The crystal habit was altered already at PVP concentrations as low as 0.001% (w
This study deals with the transformation of institutions of higher technical education in Sweden. It situates those processes in the context of educational reforms during the second half of the 20th century. Lund Institute of Technology, Lunds tekniska högskola (LTH), is focused upon. It was founded in 1961 as a major addition to the expanding higher education system. As a newly established instit
We have previously proposed a blind system identification method that exploits the underlying dynamics of non-Gaussian signals in [Li and Andersen, "Blind identification of Non-Gaussian Autoregressive Models for Efficient Analysis of Speech Signals," Proceedings of the International Conference on Acoustics, Speech and Signal Processing (ICASSP), May 2006, vol. 1, pp. I-1205-1-1208]. The signal mod
Popular Abstract in Swedish Villkoren för utbildning och undervisning förändras i väsentliga avseenden i takt med samhällets tilltagande komplexitet. Det är många gånger svårt för både lärare och elever att veta hur man på bästa sätt ska orientera sitt pedagogiska handlande. Med utgångspunkt från tre pedagogiska kontexter - grundskolan, de särskilda ungdomshemmen och grundskollärarutbildningen - pPedagogical practice is, in several important considerations, contradictory in character. In this dissertation attenention is drawn towards the field of tension that prevails between pedagogical action, which can be descibed in terms of strategic processes and communicative pedagogical action. While the former places the preconditions for effective knowledge development of the individual at the ce
Popular Abstract in Swedish I »operatörens blick« beskrivs ett projekt där möjligheter för IT-stöd i erfarenhetsöverföring undersökts inom ett område där konfrontationen mellan datorisering och yrkeskunnande är särskilt tydlig - operatörsarbete i processindustrin. Driftsstörningar av olika omfattning är ett kontinuerligt inslag i operatörsarbetet och snabba förändringar i risknivå är en central deStudies in process control automation show that manual control skills are important in handling situations where the automatic control system fails. The fact that these skills are particularly difficult to maintain and develop in automated production environments is usually described as one of the ironies of automation. This work explores new roles for computer support in developing and maintainin
The first paper, Pharmaceutical R&D: a real option approach, considers the process of pharmaceutical R&D analyzed with real option theory. This process is analyzed as an opportunity to research and develop a new pharmaceutical. Contrary to other models using real option analysis I use an option that takes time to exercise. Thus, the important aspect of long R&D processes when developin
The present study deals with free play in preeschool. The purpose is to investigate the way children conceptualize play, and the significance of play in preeschool activities. The latter has been illuminated through an analysis of normative documents, and vatious methods have been worked out that show how the possibilities of play can be made use in preschool. Group interviews with children betwee
