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The abuse of flunitrazepam (FZ) compounds is worldwide, and several studies have reflected on the consequences with regard to violence, aggression and criminal lifestyle of FZ users. Criminals take high doses of FZ or some other benzodiazepines to "calm down" before the planned crime. There is support from earlier studies that most likely, all benzodiazepines may increase aggression in vulnerable
A detailed study has been made of soot growth in two premixed flat ethylene/air flames, at I broken vertical bar = 2.1 and I broken vertical bar = 2.3, where focus has been on following the change in optical properties from nascent to more mature soot, and the importance of these properties for laser-induced incandescence (LII). A combination of two-color LII (2C-LII) and elastic light scattering
John Kingdon's Multiple Streams Framework (MSF) constitutes a powerful tool for understanding the policy process, and more specifically, agenda-setting, through three separate streams: problems, policies and politics. This article argues that the MSF would benefit from further development of the problem stream. It introduces a clearer conception of agency into the problem stream by suggesting the
HAMLET (human alpha-lactalbumin made lethal to tumor cells) interacts with multiple tumor cell compartments, affecting cell morphology, metabolism, proteasome function, chromatin structure and viability. This study investigated if these diverse effects of HAMLET might be caused, in part, by a direct effect on the ATP synthase and a resulting reduction in cellular ATP levels. A dose-dependent reduc
Background: Monoclonal antibodies (mAb) are important tools in the management of tumor disease, and the discovery of antibodies with both specific cancer cell targeting and capacity to enter the cells by internalization are critical to improve the therapeutic efficacy. Method: Antibody cancer cell targeting and internalization properties of fluoroscein-conjugated mAb made against Lewis Y (BR96) we
The visual content of out-of-body experiences (OBEs) has received little attention but a number of theories of OBEs include implicit predictions regarding the determinants of this phenomenological feature. Hypnagogic imagery and unusual sleep experiences, weak synaesthesia and preference for employing object and spatial visual imagic cognitive styles were psychometrically measured along with the i
Proteins can adjust their structure and function in response to shifting environments. Functional diversity is created not only by the sequence but by changes in tertiary structure. Here we present evidence that lipid cofactors may enable otherwise unstable protein folding variants to maintain their conformation and to form novel, biologically active complexes. We have identified unsaturated C18 f
The crystallization Process in aqueous solutions of the drug bicalutamide and the effect of the polymer polyvinylpyrrolidone (PVP) have been studied. Results showed that PVP decreased the crystallization Fate significantly in a system with PVP concentrations as low as 0.01% (w/w), without changing the polymorph formed. The crystal habit was altered already at PVP concentrations as low as 0.001% (w
Background: T1D and AITD are autoimmune disorders commonly occurring in the same family and even in the same individual. The genetic contribution to these disorders is complex making uncovering of susceptibility genes very challenging. The general aim of this study was to identify loci and genes contributing to T1D/AITD susceptibility. Our strategy was to perform linkage and association studies in
This thesis explores office paper as a medium between 1920 and 1960 in Sweden. During this period, paper was muchdebated due to the number of standards that were implemented. These standardstransformed paper, making it a modern medium in many different ways. The aim ofthe present thesis is to analyze how office paper was reshaped to solveproblems regarding production, reproduction, circulation and
Context. Observational evidence indicates that the orbits of extrasolar planets are more various than the circular and coplanar ones of the solar system. Planet-planet interactions during migration in the protoplanetary disc have been invoked to explain the formation of these eccentric and inclined orbits. However, our companion paper (Paper I) on the planet-disc interactions of highly inclined an
Microencapsulation by spray drying of oil-in-water (o/w) emulsions provides a means to encapsulate functional lipophilic ingredients. The active ingredient is dispersed in continuous solid phase providing protection. However, the encapsulation efficiency depends on the microstructure and morphology of the dry particles influenced by several mechanisms occurring during processing such as oil drople
Background: Malignant melanoma and non-melanoma skin cancers are among the fastest increasing malignancies in many countries. With the help of new tools, such as teledermoscopy referrals between primary health care and dermatology clinics, the management of these patients could be made more efficient. Objective: To evaluate the diagnostic agreement and interobserver concordance achieved when asses
Popular Abstract in Swedish Alla kroppens celler omges av olika typer av bindväv. Om cellerna liknas vid levande varelser kan bindväven liknas vid den strukturella omvärld de lever i, den kan motsvara deras hus och gator, deras skogar och hav. Man förstår då vilken oerhörd vikt denna omgivande bindväv har för cellernas välbefinnande. Vad hade vi varit utan bostäder, utan skogar, utan hav? BindväveThe functions of proteoglycans often depend on the fine structure of the covalently attached glycosaminoglycan (GAG) side-chains. The process leading to the mature GAG is complex and involves a multitude of different enzymatic steps. GAG synthesis is initiated on serine residues, where a xylose residue is transferred to the protein core, a reaction catalyzed by a xylosyltransferase (XT). It therea
Children spend a large percentage of their day with their classmates in school. Classmates are not only co-workers, but also individuals interacting socially as friends. The understanding of group affiliation and friendship interaction in school is of great importance to social work in school because of its implications on children’s wellbeing and academic performance. Several studies show that soChildren spend a large percentage of their day with their classmates in school. Classmates are not only co-workers, but also individuals interacting socially as friends. The understanding of group affiliation and friendship interaction in school is of great importance to social work in school because of its implications on children’s wellbeing and academic performance. Several studies show that so
Various improvements were made to a state-of-the-art aerosol–cloud model and comparison of the model results with observations from field campaigns was performed. The strength of this aerosol–cloud model is in its ability to explicitly resolve all the known modes of heterogeneous cloud droplet activation and ice crystal nucleation. The model links cloud particle activation with the aerosol loading
“The death of distance” has become the battle cry of a modern generation of managers, policy makers and scientists who embrace the new globalized economy and its promise of frictionless exchange across the world. While highly influential, this view does not, however, stand unchallenged. Over the last 15 years, there has been a growing interest in the geographical clustering of industry. Well-known
Popular Abstract in Swedish Alla levande organismer behöver kväve för att producera till exempel proteiner och DNA. I jorden förekommer kväve grovt indelat i två huvudformer, organiskt och oorganiskt. Mikroorganismer har förmågan att bryta ner det organiska kvävet till oorganiskt i en process som kallas för mineralisering. Växter tar i stort sett bara upp oorganiskt kväve och är beroende av den miMicroorganisms in forest ecosystems normally recycle nitrogen (N), such that gaseous losses and leaching are limited. Mobilization of organic N, including microbial N, and immobilization of inorganic N, especially NH4+, are the quantitatively most important N transformation processes. Various factors influence their rates, e.g. the amount of carbon and nitrogen, temperature, moisture, and the micr
Leachate constitutes the main potential long-term environmental risk of landfill emissions. The EU landfill directive 1999/3 I/EC requires minimum monitoring during the active landfill life and the after-care phase. Due to time and resource limitations, monitoring of leachate quality is a compromise between information density and applicability. Samples from passively collected leachate are suspec
