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Breast cancer is the most prevalent form of cancer among women in Sweden, with 9 000 diagnoses during 2023. While the five-year survival rate reaches 92.5% due to national screening programs, transitioning from 2D Digital Mammography to 3D Digital Breast Tomosynthesis (DBT) could further improve early detection. However, the high volumes of data increases the examination times, preventing it from
Classrooms are becoming increasingly digital. One novel digital technology that might enter classrooms soon is eye tracking. This is a method to estimate a person’s gaze direction and infer the point of visual attention. This technology has already provided insights into how students process computer-based instructional material. Moreover, it has been used to enhance pre-recorded video instruction
Although spatial resolution in fluorescence microscopy and related fields has advanced to the nanometer scale, time resolution has remained essentially unchanged and is set by the camera system’s imaging time. Yet adequate time resolution is crucial for information acquisition about, for instance, dynamical processes in cells. This acquisition typically proceeds by analyzing biomolecular trajector
Enzymes are dynamic entities, and their conformational dynamics are intimately linked to their function and evolvability. In this context, protein tyrosine phosphatases (PTPs) are an excellent model system to probe the role of conformational dynamics in enzyme function and evolution. They are a genetically diverse family of enzymes, with a highly conserved catalytic domain, identical catalytic mec
The RNA genome of SARS-CoV-2 contains a 5′ cap that facilitates the translation of viral proteins, protection from exonucleases and evasion of the host immune response1–4. How this cap is made in SARS-CoV-2 is not completely understood. Here we reconstitute the N7- and 2′-O-methylated SARS-CoV-2 RNA cap (7MeGpppA2′-O-Me) using virally encoded non-structural proteins (nsps). We show that the kinase
Purpose of Review: At elevated levels, the essential element manganese (Mn) is neurotoxic and increasing evidence indicates that environmental Mn exposure early in life negatively affects neurodevelopment. In this review, we describe how underlying genetics may confer susceptibility to elevated Mn concentrations and how the epigenetic effects of Mn may explain the association between Mn exposure e
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci. Cross-ancestry meta-analysis with a
Joel Penney made an innovative, interdisciplinary intervention into the scholarship on political participation with The Citizen Marketer: Promoting Political Opinion in the Social Media Age. By melding modern marketing frameworks with democratic theory, Penney offered a timely heuristic for rethinking citizens’ engagement with politics on social media. The “citizen marketer approach” developed in
One of the functional proteins in rapeseed-the amphiphilic protein oleosin-could be used to stabilize emulsions. The objectives of this study were to extract oleosins from cold-pressed rapeseed press-cake, optimize the extraction process, and investigate their emulsifying and anti-oxidative capacity. The proteins were recovered from industrially cold-pressed rapeseed press-cake at different alkali
Petrochemical enterprises in Kazakhstan discharge polluted wastewater into special recipients. Contaminants infiltrate through the soil into the groundwater, which potentially affects public health and environment safety. This paper presents the evaluation of a 7-year monitoring program from one of the factories and includes nineteen variables from nine wells during 2013–2019. Several multivariate
In this study, we investigate the responses of soil organic carbon (C) to nitrogen (N) and phosphorus (P) additions along a soil P stock gradient of five beech forest stands in Germany, using a modelling approach. Two different soil models with coupled C, N, and P cycles are used to simulate fertilization experiments conducted at the study sites. The first model, the stand-alone soil module of QUI
The aim of this study was to evaluate the degree of joint fusion and bone formation in dogs undergoing atlantoaxial arthrodesis after removal of articular cartilage associated or not to implant homogenous or autogenous cancellous bone. Twelve dogs, weighing between 8 and 12kg were randomly divided into three groups. Group I (GI) performed only the removal of joint cartilage and joint immobilizatio
The level of extracellular calcium has been demonstrated to regulate important physiological processes like cell growth and apoptosis. We demonstrate that in the bladder cancer cell line RT4, an increased extracellular calcium level induces apoptosis and that the HER1 receptor functions as a cell survival factor and delays apoptosis. After 12 h of calcium treatment (10 mM) apoptosis was detected i
Culture and discourses affect our understanding of the archive in the digital environment: preconceptions, norms, and practices developed in a paper-based administration colour and limit perceptions of digital archives. It can be difficult to reimagine the archive in the context of e-government and the networked environment, where the complexity of archival issues increases. This is a global probl
In molecular neurobiology, perhaps no molecule has been as thoroughly examined as Alzheimer's beta-amyloid precursor protein (beta-APP). In the years since the cDNA encoding beta-APP was cloned, the protein has been the subject of unparalleled scrutiny on all levels. From molecular genetics and cellular biology to neuroanatomy and epidemiology, no scientific discipline has been left unexplored - a
In molecular neurobiology, perhaps no molecule has been as thoroughly examined as Alzheimer's beta-amyloid precursor protein (betaAPP). In the ten years since the cDNA encoding betaAPP was cloned, the protein has been the subject of unparalleled scrutiny on all levels. From molecular genetics and cellular biology to neuroanatomy and epidemiology, no scientific discipline has been left unexplored -
Using a penalized maximum likelihood, we estimate, for the first time, the velocity distribution of white dwarfs in the solar neighbourhood. Our sample consists of 129 675 white dwarfs within 500 pc in Gaia Early Data Release 3. The white dwarf velocity distributions reveal a similar structure to the rest of the solar neighbourhood stars, reflecting that white dwarfs are subject to the same dynami
PURPOSE: To evaluate vertical acceleration, vector magnitude, non-wear time, valid day classifications and valid period classifications, in the data processing phase when using the ActiGraph GT3X accelerometer in non-ambulant children and adolescents with cerebral palsy (CP).MATERIAL AND METHODS: Accelerometer data retrieved from 33 non-ambulant children and adolescents (4-17 years) with CP, were
Fluid anomalies were often considered as possible precursors before earthquakes. However, fluid properties at the surface can change for a variety of reasons, including environmental changes near the surface, the response of the superficial fluid system to loads associated with the mechanical nucleation of earthquake fractures, or as a result of transients in fluid flow from the depths. A key prob
Aims: We investigated the sequential gene expression in the gingiva during the induction and resolution of experimental gingivitis. Material and Methods: Twenty periodontally and systemically healthy non-smoking volunteers participated in a 3-week experimental gingivitis protocol, followed by debridement and 2-week regular plaque control. We recorded clinical indices and harvested gingival tissue
