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Enzymes are dynamic entities, and their conformational dynamics are intimately linked to their function and evolvability. In this context, protein tyrosine phosphatases (PTPs) are an excellent model system to probe the role of conformational dynamics in enzyme function and evolution. They are a genetically diverse family of enzymes, with a highly conserved catalytic domain, identical catalytic mec
Following the recent resurgence of capitalism as a key subject in historical analysis, historians have highlighted the globally interconnected making and remaking of capitalism. Commodity-centred histories in global history have shown how to write locally grounded histories of global capitalism emphasising the complex and contingent relationship between the local and the global. In these accounts,
This study examines the views of stakeholders involved in house renovations regarding the one-stop-shop business concept innovation, and assesses their level of preparedness to adopt such a concept in order to enter the promising market of detached house renovations. The investigation is based on 25 interviews with construction SMEs owners, real estate agents and loan consultants, and on a concept
Background Multiple myeloma cells uniformly overexpress CD38. We studied daratumumab, a CD38-targeting, human IgG1κ monoclonal antibody, in a phase 1-2 trial involving patients with relapsed myeloma or relapsed myeloma that was refractory to two or more prior lines of therapy. Methods In part 1, the dose-escalation phase, we administered daratumumab at doses of 0.005 to 24 mg per kilogram of body
In molecular neurobiology, perhaps no molecule has been as thoroughly examined as Alzheimer's beta-amyloid precursor protein (beta-APP). In the years since the cDNA encoding beta-APP was cloned, the protein has been the subject of unparalleled scrutiny on all levels. From molecular genetics and cellular biology to neuroanatomy and epidemiology, no scientific discipline has been left unexplored - a
In molecular neurobiology, perhaps no molecule has been as thoroughly examined as Alzheimer's beta-amyloid precursor protein (betaAPP). In the ten years since the cDNA encoding betaAPP was cloned, the protein has been the subject of unparalleled scrutiny on all levels. From molecular genetics and cellular biology to neuroanatomy and epidemiology, no scientific discipline has been left unexplored -
Popular Abstract in Swedish Kostfiber visar på gynnsamma effekter på blodsockersvar, inflammationsmarkörer och blodfetter utifrån tre humanstudier som genomfördes i detta arbete. I en av studierna analyserades blod och urin med metabolomik. Det är en metod där man analyserar alla små molekyler (metaboliter) som finns i provet med hjälp av vätskekromatografi kopplat till masspektrometri. Med hjälp It is well-known that dietary fibre can have a positive effect on the development of lifestyle-dependent diseases such as cardiovascular disease and type 2 diabetes. However, the effect may be different for different kinds of fibre and different sub-populations at risk. Therefore, the effects of three different kinds of fibre on postprandial and long-term response in healthy subjects were investig
The business model concept is becoming increasingly popular within e-businesses and e-business research. However, the concept is often used relatively independently from theory, meaning model components and their interrelations are relatively obscure. This paper analysis three e-business models taxonomies based on a generic business model, which include customers and competitors, the offering, act
Leachate constitutes the main potential long-term environmental risk of landfill emissions. The EU landfill directive 1999/3 I/EC requires minimum monitoring during the active landfill life and the after-care phase. Due to time and resource limitations, monitoring of leachate quality is a compromise between information density and applicability. Samples from passively collected leachate are suspec
One major problem for integrating study results into a common body of knowledge is the heterogeneity of reporting styles: (1) It is difficult to locate relevant information and (2) important information is often missing. Reporting guidelines are expected to support a systematic, standardized presentation of empirical research, thus improving reporting in order to support readers in (1) finding the
Agriculture in India is characterised by low productivity, and structural change has been slow and unconventional. Nevertheless, at state-level one can identify different patterns for these process. The attempt in this work has been to understand the linkages between farm mechanisation, agricultural productivity and structural change at the state-level during the post-reform period. The aim was to
Denna uppsats undersöker räckvidden av det straffrättsliga ansvaret för försök till sexualbrott mot barn på nätet när polisen uppträder som barn, samt hur detta ansvar förhåller sig till rätten till en rättvis rättegång enligt artikel 6 i EKMR. Rättsläget har förändrats påtagligt under de senaste åren. Genom NJA 2023 s. 393 ”Vapenattrappen” preciserade Högsta domstolen det straffbara området för This thesis examines the scope of criminal liability for attempted sexual offences against children online when a police officer impersonates a child, and how this liability relates to the right to a fair trial under Article 6 of the ECHR. The legal position has shifted markedly in recent years. In NJA 2023 p. 393 "Vapenattrappen" (The weapon replica), the Supreme Court of Sweden clarif
The aim of this master thesis is to investigate if WTO members' shifting behaviour in the Dispute Settlement Mechanism may be explained using a game theoretic approach. To do this, the author uses a three step process: First, a thorough quantitative analysis of how the DSM works and how the members behave in it is carried out. Second, with the result from the first part in mind, a game theore
The purpose of this thesis is to examine how the issue of car dependency is represented within the transportation system of Region Skåne and how that representation shapes the region’s strategy for mobility. This is done through a document analysis of the active version of the transportation strategy from 2017 as well as the soon-to-be implemented draft version from 2025 using the “What’s the prob
Trans parenting, scarcely explored in scientific literature, is often treated through the lens of accessibility to procreation technology, state of legislation or experiences of family continuity. A “doing family practice” approach allows us to explore how trans parenthood is conceived in actions for trans parents in France. Through narrative interviews, a “doing family” approach to parenthood, an
The United Nations High Commissioner for Refugees (UNHCR) has estimated that around 120 million people are forcibly displaced around the world and about 32 million of them are refugees. Our aim with this study was to examine and demonstrate the process of forced migration from people's home countries based on a refugee perspective. The method used was a qualitative text analysis of autobiograp
Passive radiators are components that can be integrated into loudspeakers to amplify the bass frequencies. To ensure good sound quality, the passive radiator, the speaker driver, and the loudspeaker enclosure must all be well-dimensioned and fine-tuned in relation to each other. This master’s thesis, written at the Department of Design Sciences at Lund University, aims to deliver a set of general
Accurately predicting terrestrial ecosystem responses to climate change over long-timescales is crucial for addressing global challenges. This relies on mechanistic modeling of ecosystem processes through land surface models (LSMs). Despite their importance, LSMs face significant uncertainties due to poorly constrained parameters, especially in carbon cycle predictions. This paper reviews the prog
Although spatial resolution in fluorescence microscopy and related fields has advanced to the nanometer scale, time resolution has remained essentially unchanged and is set by the camera system’s imaging time. Yet adequate time resolution is crucial for information acquisition about, for instance, dynamical processes in cells. This acquisition typically proceeds by analyzing biomolecular trajector
