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Inom nuklearmedicinen utnyttjas radioaktiva läkemedel och strålningen som sänds ut från dessa för att diagnosticera och behandla ett flertal olika sjukdomar. Det radioaktiva läkemedlet ges ofta till patienten som en intravenös injektion, och läkemedlets egenskaper i kombination med patientens fysiologi och eventuella sjukdom avgör hur läkemedlet sedan fördelas, omsätts och utsöndras från kroppen. Many nuclear medicine investigations rely on gamma-camera imaging to study and quantify the distribution of radiopharmaceuticals or radionuclides in the patient as a function of time. This is typically used for diagnostic studies of physiological functions or for calculation of absorbed doses following radionuclide therapy. In this work, computational patient models (phantoms) have been developed

MOTIVATION: Neutrophil extracellular traps (NETs) are believed to be essential in controlling several bacterial pathogens. Quantification of NETs in vitro is an important tool in studies aiming to clarify the biological and chemical factors contributing to NET production, stabilization and degradation. This estimation can be performed on the basis of fluorescent microscopy images using appropriate

Background: PSMA PETs can track treatment response in patients with prostate cancer. Recent integration of the RECIP framework with PROMISE v2 allows quantitative assessment of PSMA PETs. While useful for assessing differentially responding lesions, manual measurement and tracking is cumbersome and PSA reliance can be misleading. We evaluated an automated AI-enabled platform, aPROMISE, for longitu

The volcanic island of Jan Mayen, located in the Norwegian – Greenland Sea, has very few lake basins out of which only one, Lake Nordlaguna, holds a permanent lake throughout the year. The island is volcanic and has been glaciated, but the lake basin is not genetically typical for volcanic crater lakes or other common types of volcanic lakes. Nor is it typical for ice-scoured glacial lakes. Instea

A striking feature of nucleic acids and lipid membranes is that they all carry net negative charge and so is true for the majority of intracellular proteins. It is suggested that the role of this negative charge is to assure a basal intermolecular repulsion that keeps the cytosolic content suitably ‘fluid’ for function. We focus in this review on the experimental, theoretical and genetic findings

A sports-related concussion (SRC) is most commonly sustained in contact sports, and is defined as a mild traumatic brain injury. An exercise-induced elevation of core body temperature is associated with increased brain temperature that may accelerate secondary injury processes following SRC, and exacerbate the brain injury. In a recent pilot study, acute head-neck cooling of 29 concussed ice hocke

OBJECTIVE: To investigate potential risk factors behind the increased incidence of necrotising enterocolitis (NEC) in Swedish extremely preterm infants.DESIGN: Registry data from two population-based national cohorts were studied. NEC diagnoses (Bell stage ≥II) were validated against hospital records.PATIENTS: All liveborn infants <27 weeks of gestation 2004-2007 (n=704) and 2014-2016 (n=895) in S

Quantitative in-cylinder measurements of soot volume fraction in a single-cylinder HSDI Diesel engine, based on a VOLVO D5, has been carried out using the laser-induced incandescence (LII) technique using laser excitation at 1064 nm and an ICCD camera with prompt gate detection. Quantitative data was obtained by relating the LII signal response from the engine to that from a calibration flame. The

One of the most significant political changes over the past 25 years in Tamil Nadu, as elsewhere in India, is the implementation of a statutory status for a local elected government in accordance with the 73rd and 74th amendments to the Constitution passed by the Indian Parliament in 1993. The performance of the new system in Tamil Nadu is rather average and not very vibrant. Nevertheless, it has

The second generation (2G) cellular networks are the current workhorse for machine-to-machine (M2M) communications. Diversity in 2G devices can be present both in form of multiple receive branches and blind repetitions. In presence of diversity, intersymbol interference (ISI) equalization and co-channel interference (CCI) suppression are usually very complex. In this paper, we consider the improve

Popular Abstract in Swedish Ämnet för denna sammanläggningsavhandling är lärande i en svensk konsthögskolekontext. Det finns sparsamt med forskning som avser högre utbildning i fri konst, och vi vet inte mycket om studenternas lärandeprocesser. Vilka kvaliteter utvecklar studenterna under utbildningen, och hur främjas utvecklingen av dessa kvaliteter? I linje med dessa grundläggande frågor, är detThe object of research in this thesis is learning within the context of a practice-based Master of Fine Arts program in visual art in Sweden. Research on learning in visual art practice within higher education is sparse, and we know little of the students’ learning processes. What qualities do the students actually develop during their studies? How may the development of these qualities be support

Background: A large number of individuals with Alzheimer’s disease (AD) live alone and receive little or no help from family members, which implies an additional pressure on the increasing societal costs of dementia care. Their adult children, if any, might have very limited ability to assist by providing informal help because of social structural changes, such as full-time work for most women and

Homelessness became a conspicuous facet of Russian metropolitan cityscapes only in the 1990s, when the Soviet criminalization of ‘vagrancy’ and similar offences was abolished. This study investigates homelessness as a sociostructural phenomenon as well as an individually experienced life condition, with a focus on homeless people in St. Petersburg in 1999 onwards. To these men and women, homeless

The major objective of this thesis was to produce descriptions of the land vegetation-cover in Europe for selected time windows of the Holocene (6000, 3000, 500, 200, and 50 calendar years before present (BP=1950)) that can be used in climate modelling. Land vegetation is part of the climate system; its changes influence climate through biogeophysical and biogeochemical processes. Land use such as

Inom läkemedelsindustrin är det väldigt viktigt att göra en noggrann kontroll av läkemedel så att de är tillräckligt rena för personen som ska använda dem. En vanlig analysteknik i industrin är HPLC (High Performance Liquid Chromatography), som används för att separera och identifiera olika ämnen i exempelvis krämer eller tabletter. Analysmetoden används för att upptäcka orenheter i produkterna. HPLC is one of the most widely used analytical techniques in the pharmaceutical industry used for separation and identification of compounds in complex formulations. Despite its advantages, HPLC method development remains challenging. This is due to the need to optimize multiple interdependent parameters simultaneously, while gaining high precision, reproducibility, and efficiency. Even minor cha

Neural tissue grafting can be highly effective and constitutes a potentially curative approach for progressive neurodegenerative disorders such as PD. Virtually all signs and symptoms of PD have been shown to improve after grafting but not necessarily simultaneously in one patient. Several technical aspects require improvement before widespread use of neural tissue implants can be recommended. The

Flooding is one of the main social impacts in urban areas, especially in larger, densely impermeable cities. Therefore, developing studies capable of identifying areas that are vulnerable to this type of event is crucial to provide early warning and a quick and effective response to reduce damages. Thus, this study sought to identify areas vulnerable to flood in the Igapó Lake Basin, a densely urb