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Shortcomings of current techniques used for the intracerebral transplantation of ventral mesencephalic dopamine neurons include low graft survival, high variability, considerable implantation trauma and suboptimal graft integration. In order to overcome these limitations, we have adopted a microtransplantation approach which allows precise and reproducible implantation of ventral mesencephalon cel

Diagnostic reference levels are the main and the most effective tools of optimization of the radiation protection of patients from medical exposure. Diagnostic reference levels should be established based on theresults of dedicated dose surveys, allowing evaluating typical patient dose distributions in a selected dose quantity for the selected X-ray examinations. The aim of the current study was t

Children with Down syndrome (DS) using intensive computer-based phonics (GraphoGame, GG) were studied. The children's independence and improvement in phonological processing, letter knowledge, word decoding, and reading strategies were investigated. Seventeen children (5-16 years) with DS participated in a crossover design through 8 weeks (one period), with three test sessions separated by 4 weeks

Membrane emulsification is a gentle process that produces emulsions with a narrow drop size distribution, which increases the stability of the emulsion. The dispersed phase is forced through the pores in a membrane and drops are formed at the other side of the membrane where a continuous phase, flowing along the membrane surface, sweeps away the forming drops. The growth and detachment of drops is

This paper deals with the question how urban crises – whether political, economic, financial, environmental or social – are defined, constructed, or discursively and materially appropriated by urban elites to serve their agendas of urban reform. Inspired by the work of Klein (2007), Smith (2005) and others, it will be argued that specific ‘emergency’ framings of urban decline, impoverishment, disa

Conventional wastewater treatment plants are designed for treating manmade wastewater (e.g., from households and industries) and to protect the environment (e.g., receiving water bodies) and humans from adverse effects.The objective of this work was to investigate the feasibility of treating municipal wastewater without a biological treatment step by applying different separation processes, such a

AbstractThe present compilation thesis is divided into two sections, one for each of two separate methodological issues: reduction of random errors in mortality estimates and offsetting random variation related bias in data generated estimators of risk inequalities.Summary of section AIn regard to the first issue a new family of survival functions is proposed. Its purpose is to provide valid and rThe present compilation thesis is divided into two sections, one for each of two separate methodological issues: reduction of random errors in mortality estimates and offsetting random variation related bias in data generated estimators of risk inequalities. Summary of section A In regard to the first issue a new family of survival functions is proposed. Its purpose is to provide valid and reliabl

This study presents the results of a set of large-scale fire tests performed on horizontal polyurethane foam slabs. Slab thickness, ignition location, and environment (free burn or corner wall) were varied over 23 individual tests. In a continuation of a previous study by the authors, four different slab thicknesses, five different ignition locations, and three environmental modification combinati

The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75–78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on mult

Formate dehydrogenases (FDHs) are metalloenzymes that catalyse the reversible conversion of formate to carbon dioxide. Since such a process may be used to combat the greenhouse effect, FDHs have been extensively studied by experimental and theoretical methods. However, the reaction mechanism is still not clear; instead five putative mechanisms have been suggested. In this work, the reaction mechan

Background: Chronic kidney disease, cardiovascular disease, and cognitive dysfunction are common in the elder population. There is evidence of a connection between these conditions, possibly by a shared vascular pathogenesis. Processing speed is commonly impaired in cerebrovascular disease. Methods: The data was obtained from the population based study “Good aging in Skåne” (GÅS), and included 905

Active ageing (AA) policies aim to improve quality of life of older people by enabling better social participation and inclusion. Despite many international initiatives to promote AA undertaken in recent years, Italy did not systematically address this policy challenge until very recently. This paper presents the first national Plan-of-Action (PoA) (2019–2022) adopted by this country for supportin

Background and aims: Environmental and genetic factors predispose to cardiovascular disease. Some first-generation immigrants have a higher cardiovascular risk in Sweden, while less is known about second-generation immigrants. We aimed to analyze the risk of acute myocardial infarction (AMI) among second-generation immigrants in Sweden. Methods: We included all individuals 18 years of age and olde

This article argues that despite the fact that “good governance” has acquired a very particular set of meanings within the international development community, this remains an inherently contested and political concept. It traces the emergence of a good governance agenda within international development—and particularly within the World Bank—and identifies the important shifts that have occurred i

The cellular polyamines spermine, spermidine, and their metabolic precursor putrescine, have long been associated with cell-growth, tumor-related gene regulations, and Alzheimer's disease. Here, we show by in vitro spectroscopy and AFM imaging, that these molecules promote aggregation of amyloid-beta (Aβ) peptides into fibrils and modulate the aggregation pathways. NMR measurements showed that the

This paper presents an in-depth analysis of the stability and performance of control systems experiencing sensor timing misalignments, a common challenge in practical applications such as autonomous vehicles and aerospace systems. We model multichannel sensor delays as independent random variables, capturing the variability of real-world systems where different sensors exhibit distinct and non-con

The preferred treatment of choice in muscle-invasive bladder cancer (MIBC) is usually transurethral resection followed by cystectomy, with neoadjuvant chemotherapy being a second option. As the treatment is associated with relevant side effects, a great effort is being made to improve the selection of patients, with molecular subtyping being one of the main strategies. Our aim was to develop an im

AimTo analyze the impact of a time-gain selective, first-responder dispatch system on the presence of a shockable initial rhythm (SIR), return of spontaneous circulation (ROSC) and 30-day survival after out-of-hospital cardiac arrest (OHCA).MethodA retrospective observational study comprising OHCA registry data and dispatch data in the Skåne Region, Sweden (2010–2018). Data were categorized accord