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The global methylation profile and the mutational status of 633 specific epigenetic regulators were analyzed in the pediatric tumor clear cell sarcoma of the kidney (CCSK). Methylation array analyses of 30 CCSKs revealed CCSK tumor DNA to be globally hypermethylated compared to Wilms tumor, normal fetal kidney, and adult kidney. The aberrant methylation pattern of CCSKs was associated with activat

We present a qualitative physical model of the origin of two very brightUV lines of Fe II at 2507-2509 Å, present in high-resolutionspectra of gaseous condensations (blobs) close to the central star ofeta Carinae. The spectra have been obtained with the Hubble SpaceTelescope (HST). The model is based on a type of Bowen mechanism withselective photoexcitation of Fe II by a broad HLyalpha profile,ge

Aims: A study was undertaken to examine whether poor self-rated health (SRH) can independently predict all-cause mortality during 22-year follow-up in middle-aged men and women. Subjects and methods: Data are derived from a population-based study in Malmo¨ , Sweden. This included baseline laboratory testing and a self-administered questionnaire. The question on global SRH was answered by 15,590 me

The effect of gamma irradiation (60Co) with doses of 5–30 kGy on the amylose–lipid complex transition and retrogradation occurring in gels containing ca. 50% and ca. 20% wheat starch was studied by differential scanning calorimetry (DSC) during heating–cooling–heating cycles (up to three cycles). Transition of the amylose–lipid complex occurs in all the irradiated samples at a lower temperature as

This paper presents a preliminary model of the occupational history of the valley bottoms at the edges of the bed of the Quequén Grande River (Argentina) during the late Holocene. The ultimate goal of the research is to situate some aspects of technology, mobility, land-use patterns and settlement systems as a proximal consequence of a long-term process of 'lithification', that is, the positioning

Popular Abstract in Swedish Potatis har varit, och är fortfarande ett viktigt baslivsmedel i svensk kosthållning. Det finns många sorter med olika egenskaper vilket bidrar till dess variationsrikedom. Potatisen är en rik källa till stärkelse, kostfibrer samt vitaminer och mineraler, t ex C-vitamin och järn. En invändning mot potatis ur nutritionell synvinkel är att stärkelsen lätt bryts ned av enzDespite decreased consumption potatoes still constitute an important staple in the Swedish diet. An objection to potatoes and potato products from a nutritional point of view is the ease by which the starch is digested and absorbed in the gastrointestinal tract. This results in unfavourably high glycaemic and insulinaemic responses (glycaemic index, GI and insulinaemic index, II, respectively). Su

Objective: To investigate the relationship between meniscus magnetic resonance (MR) relaxation parameters and meniscus degradation through quantitative imaging of ex vivo posterior horns of menisci from subjects with and without knee osteoarthritis (OA). Design: We sampled medial and lateral menisci from ten medial compartment knee OA patients (mean age 63 years) undergoing total knee replacement

The focus of this work is detecting pedestrians, captured in a surveillance setting, and locating them in world coordinates. Commonly adopted search strategies operate in the image plane to address the object detection problem with machine learning, for example using scale-space pyramid with the sliding windows methodology or object proposals. In contrast, here a new search space is presented, whi

The high-spectral-resolution optical studies of the energy gap evolution, supplemented with electronic, magnetic, and structural characterization, show that the modification of the GaAs valence band caused by Mn incorporation occurs already for a very low Mn content, much lower than that required to support ferromagnetic spin-spin coupling in (Ga,Mn)As. Only for n-type (Ga,Mn)As with the Mn conten

AIMS : Transcatheter aortic valve implantation (TAVI), now a common procedure to treat high-risk patients with severe aortic stenosis, has rapidly been expanding into younger and lower-risk populations, creating a need to better understand long-term outcome after TAVI. The aim of the present investigation was to determine the incidence, risk factors for, clinical presentation of, and outcome after

This study was undertaken to evaluate the role of internalization in the action of the peptide autacoid bradykinin (BK). At 4°C [3H]BK binds to an apparently single class of B2 kinin receptors on DDT1 MF-2 smooth muscle cells (C. M. Munoz, S. Cotecchia, and L. M. F. Leeb-Lundberg, manuscript submitted). At this temperature the [3H]BK binding was confined exclusively to the cell surface. On the oth

Surface-enhanced Raman spectroscopy is a popular tool for the detection of extremely small quantities of target molecules. Au nanoparticles have been very successful in this respect due to local enhancement of the light intensity caused by their plasmon resonance. Furthermore, Au nanoparticles are biocompatible, and target substances can be easily attached to their surface. Here, we demonstrate th

The food sector is currently very inefficient due to a large amount of food waste it generates, and the volumes of water and energy used. This problem is aggravated by increasing economic costs and stricter regulations associated with the disposal and treatment of food waste, carbon emissions and wastewater discharge. Because of this, resource efficiency is key to a sustainable food system. In thi

Three interlaboratory tests conducted by European laboratories were studied, in which 37 laboratories participated in 2018, rising to 46 in 2019 and 2020. A RTFO-aged neat bitumen 20/30 and PMB 45/80-55 in RTFO-aged and unaged conditions were tested using a DSR at frequency of 1.59 Hz with PP08 and PP25 geometries at temperatures ranging from 10°C to 65°C. To assess variation in numerous areas of

In order to improve the surface quality of TC4 titanium alloy parts, the effect of grinding parameters on surface integrity must be known. In this research, an experimental analysis has been conducted to understand the effect of grinding parameters, including cutting velocity, feed rate, grinding depth and abrasive size, on material removal and surface integrity. Before conducting experiment, test

We present a study of high-order-harmonic generation (HHG) assisted by extreme ultraviolet (XUV) attosecond pulses, which can lead to the excitation of inner-shell electrons and the generation of a second HHG plateau. With the treatment of a one-dimensional model of krypton, based on time-dependent configuration interaction singles (TDCIS) of an effective two-electron system, we show that the XUV-

In this letter, the fading statistics of wireless channels in high-speed railway cutting scenarios are characterized based on measurements. A multiple scattering model called second-order scattering fading (SOSF) is used to model the small-scale fading considering the influence of cuttings and bridges. The SOSF model can offer the possibility of analytical estimation for different fading severitie

OBJECTIVE:: Arterial stiffening increases with age and is associated with increased cardiovascular risk. Several risk factors have been shown to predict the development of arterial stiffening; however, a positive family history (FH+) of cardiometabolic disease (CMD) and hypertension has not been extensively studied. We hypothesize that FH+ of CMD plays a significant role in the development of arte