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PURPOSE: Renal cell carcinoma (RCC) is derived from a tissue with a remarkable capacity for vectorial transport. We therefore performed an unbiased exploration of transporter proteins in normal kidney and kidney cancer in order to discover novel clinical targets.EXPERIMENTAL DESIGN: Using the TCGA database we investigated differences in membrane transporter expression in ccRCC and normal kidney. W
Aims. Helium-like ions provide an important X-ray spectral diagnostics in astrophysical and high-temperature fusion plasmas. An interpretation of the observed spectra provides information on temperature, density, and chemical compositions of the plasma. Such an analysis requires information for a wide range of atomic parameters, including energy levels and transition rates. Our aim is to provide a
For more than 30 years since it was first proposed by Harrington et al., the Theory of Characteristic Mode (TCM) has only been applied to perfect electric conductors (PEC), and more recently lossless dielectric materials. One key challenge in computing the characteristic modes (CMs) of non-PEC materials using the PMCHWT surface integral equation is the presence of internal resonances in the soluti
Popular Abstract in Swedish Denna avhandling syftar till att belysa vilket professionskunnande som blivande lärare ges möjlighet att utveckla under sin högskoleförlagda utbildning och hur detta professionskunnande kan karaktäriseras. Detta belyses genom ett antal forskningsfrågor: Vilka olika undervisningspraktiker konstituerar den högskoleförlagda lärarutbildningen? På vilket sätt upprättas dessaThe starting point for this dissertation was the reform of the school system in Sweden with consequences for teachers´ work and new demands on their professional knowledge. This thesis aims to illuminate the issue of what professional knowledge student teachers are offered during their time in the university, and how this professional knowledge can be characterised. This is carried out with respec
[1] Vigorous debate still surrounds the cloud electrification process and unexplained regional variations in lightning activity. Here, we show that climatological maxima in lightning activity are associated with small effective diameter D-e of ice crystals near cumulonimbus cloud tops. This relationship, unlike lightning's more well-known relationship with cloud top height, is consistent over land
PowerPoint-presentation Staff meeting CEC, INES & geology 2024-08-22 Ahead of a possible decision to co-organise CEC, INES and Geology Welcome to this staff meeting organised in three sessions: CEC: 10:00-11:00 Geology: 13:00-14:00 INES: 14:15-15:15 No co-organisation Co-organisation Changes Name and vision No co-organisation No organisational change Co-location of CEC, INES and Geology at
A sustainable development was defined by the Brundtlandscommission for the United Nations Conference on Environment and Development as "... a development that meets present needs without compromising future generations to meet their own needs". The definition includes a broad consideration of economic, environmental and social aspects. The definition thus creates a good example of the
Problem definition: Companies competing in a market environment are trying to improve their competitiveness. A widespread company strategy is to focus on the core operations and competencies and outsource non-core activities. Managing companies’ vehicle fleets is often considered non-core operations which have led to the creation of the operational vehicle leasing industry. It means that the leasi
Qinghai-Tibet Plateau grasslands are unique geographical regions and store substantial soil organic matter (SOM) in the soil surface, which make them very sensitive to global climate change. Here, we focused on three main grassland types (alpine meadow, steppe, and desert) and conducted a soil incubation experiment at five different temperatures (5, 10, 15, 20, and 25°C) to investigate SOM decompo
Background: Listening effort seems to depend on input-related listening demands and several factors internal to the individual listener. Input-related demands may be listening in noise compared with listening in quiet, and internal factors may be cognitive functions. Purpose: The purpose was to apply measures of listening effort and perceived listening effort in participants with normal hearing, t
Macromolecular crowding in biological media is an essential factor for cellular function. The interplay of intermolecular interactions at multiple time and length scales governs a fine-tuned system of reaction and transport processes, including particularly protein diffusion as a limiting or driving factor. Using quasielastic neutron backscattering, we probe the protein self-diffusion in crowded a
Reliable information on solar activity over the Holocene period is important to predict the Sun in the future and to understand the mechanism behind the Sun-climate linkage. Presently, there are discrepancies in the proxy data of solar activity due to reasons that are not yet understood. This leads to major uncertainties in Holocene solar reconstructions. This PhD project aims to improve the Holoc
Metallic nano-antennas are devices used to concentrate the energy in light into regions that are much smaller than the wavelength. These structures are currently used to develop new measurement and printing techniques, such as optical microscopy with sub-wavelength resolution, and high-resolution lithography. Here, we analyze and design a nano-antenna in a two-dimensional setting with the source b
BACKGROUND: Many factors influence housing choices among older adults, but far from all have been identified. There is little systematic analysis that has included economic factors and virtually no knowledge about the interplay among perceived costs of moving, health status, and the mobility rate of older homeowners. It is currently unclear whether economic factors influence older adults' willingn
The steel and chemical production industries are the largest industrial emitters of greenhouse gases in the European Union, together accounting for half of the EU’s industrial greenhouse gas (GHG) emissions. A promising strategy for achieving deep GHG emissions reductions is the electrification of these two industries, which would depend on the rapid expansion of renewable electricity supply. Such
The Cherenkov Telescope Array (CTA) will be the next generation gamma-ray observatory and will be the major global instrument for very-high-energy astronomy over the next decade, offering 5 − 10 × better flux sensitivity than current generation gamma-ray telescopes. Each telescope will provide a snapshot of gamma-ray induced particle showers by capturing the induced Cherenkov emission at ground le
As video and computer games get increasingly more advanced, the immersive experience for the player of these games also follows this trajectory. In these games, one aspect that has been explored to the greatest extent is that of choice and player agency. Often, these choices and acts are of a moral character, whether it be choosing what to do on an ambiguously formulated questline with multiple br
The Amazon rainforest is highly biodiverse and has the largest extent of the remaining intact tropical forests in the world. To this day, undisturbed tropical forests act as a carbon sink by taking up about 15% of anthropogenic carbon emissions per year. However, in the past decades, a declining trend in the carbon sink capacity in the Amazon rainforest has been observed due to increased carbon lo
Atrial fibrillation (AF) is the most common arrhythmia in the world, leading to a significant burden to patients and the healthcare system. It is characterised by rapid and irregular atrial contractions stemming from disorganised electrical activity in the atria. The atrioventricular (AV) node regulates heart rate during AF by filtering electrical impulses from the atria.However, for persistent AF
BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospect
