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Dominant pole placement for multi-loop control systems

This paper proposes a method for multi-loop PI controller design which can achieve dominant pole placement for two input two output processes. It is an extension of the original dominant pole design (PID Controllers: Theory, Design, and Tuning, Instrument Society of America, Research Triangle park, NC, 1995.) for SISO systems. Unlike its SISO counterpart, where the controller parameters can be obt

Development of and Recovery from Secondary Hypogonadism in Aging Men: Prospective Results from the EMAS

Context: Secondary hypogonadism is common in aging men; its natural history and predisposing factors are unclear. Objectives: The objectives were 1) to identify factors that predispose eugonadal men (T >= 10.5 nmol/L) to develop biochemical secondary hypogonadism (T < 10.5 nmol/L; LH <= 9.4 U/L) and secondary hypogonadal men to recover to eugonadism; and 2) to characterize clinical features associ

Exit Pursued by a Bugbear : Stage Renderings of Mythical Moments in The Winter's Tale

This paper takes as its starting‑point three particular moments in The Winter’s Tale (Exit pursued by a bear (3.1), Time (4.1) and the Statue scene (5.3) – moments that have become famous, or infamous, even mythical, by being so difficult to stage1. Having worked intensively with The Winter’s Tale throughout the academic year 2012/13 (among other things directing it with two consecutive groups of

Decision-making in critical situations during pregnancy and birth

The overall aim of this thesis was to describe the experiences of obstetricians and parents and the attitudes of midwives in relation to critical situations during pregnancy and birth. The data collection (Paper I and II) started in year 2000 with interviews with obstetricians (n=14) concerning the meaning of being in ethically difficult situations. During 2002 to 2004 interviews with parents (n=2

Synthetic studies on naphthoxylosides - labeled compounds and mechanistic studies on acetals

Labeled analogs to an antiproliferative naphthoxyloside have been synthesized and evaluated. Our investigations have shown that the fluorescently labeled analogs are poor structural analogs, and the physical and biological properties are altered to a large extent. Instead, a radioactively labeled compound was synthesized, which made it possible to follow the pathway in the cell. The results showed

Critical obstetric situations - obstetricians' ethical decision-making and parents' handling of threat of preterm birth

Ethical issues arise in obstetric situations and demand the obstetrician’s moral consideration for those who are involved in the actual case (Paper I). A balance between the health of the foetus and the autonomy of the woman is necessary to do the best for both the mother and her foetus/infant. Preterm birth is one of the main causes of mortality and morbidity for the child, in short and long term

Feasibility Study of the Electrokinetic Remediation of a Mercury-Polluted Soil

This chapter is focused on the study of electroremediation of heavy metals from a real soil. Specifically, the case of the study was a soil from Almaden mining district, with a very high mercury concentration. The risk assessment of heavy metals depends on the mobility and bioavailability and not only on the total concentration. Therefore, this study evaluates the distribution of mercury into diff

Simultaneous determination of fragmentation and coalescence rates during pilot-scale high-pressure homogenization

The emulsification process is primarily determined by the rate of fragmentation and coalescence of emulsion drops. However, there is presently no fast, reliable method for measuring these rates for pilot and production scale high pressure homogenizers. In this paper a method for simultaneous estimating fragmentation and coalescence is developed and tested based on the work of Hounslow and Ni (2004

Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment

The aspartic protease cathepsin D, a poor prognostic indicator of breast cancer, is abundantly secreted as procathepsin D by human breast cancer cells and self-activates at low pH in vitro, giving rise to catalytically active cathepsin D. Due to a lower extracellular pH in tumor microenvironments compared to normal tissues, cathepsin D may cleave pathophysiological substrates contributing to cance

Robust Surface Doping of Bi2Se3 by Rubidium Intercalation

Rubidium adsorption on the surface of the topological insulator Bi2Se3 is found to induce a strong downward band bending, leading to the appearance of a quantum-confined two-dimensional electron gas state (2DEG) in the conduction band. The 2DEG shows a strong Rashba-type spin orbit splitting, and it has previously been pointed out that this has relevance to nanoscale spintronics devices. The adsor

Evaluating the Machinability of Inconel 718 Using Polar Diagrams

Abstract in UndeterminedThe use of a polar diagram method for describing and evaluating the machinability ofInconel 718 was explored. Five key parameters of the work material, representing themechanical and physical properties, which have the strongest influence on its machinability,were employed in the diagrams. These five parameters were integrated into asingle polar diagram, used to describe th

Off-resonance rotating-frame relaxation dispersion experiment for (13)C in aromatic side chains using L-optimized TROSY-selection.

Protein dynamics on the microsecond-millisecond time scales often play a critical role in biological function. NMR relaxation dispersion experiments are powerful approaches for investigating biologically relevant dynamics with site-specific resolution, as shown by a growing number of publications on enzyme catalysis, protein folding, ligand binding, and allostery. To date, the majority of studies

Strategies for the enzymatic enrichment of PUFA from fish oil

PUFA from oil extracted from Nile perch viscera were enriched by selective enzymatic esterification of the free fatty acids (FFA) or by hydrolysis of ethyl esters of the fatty acids from the oil (FA-EE). Quantitative analysis was performed using RP-HPLC coupled to an evaporative light scattering detector (RP-HPLC-ELSD). The lipase from Thermomyces lanuginosus discriminated against docosahexaenoic

The structure of allozyme variation in Silene nutans (Caryophyllaceae) in Denmark and in north-western Europe

We used allozymes to investigate the structure of genetic variation in populations of the perennial herb Silene nutans at local (Denmark), regional (Nordic area) and wide (over a 19A degrees latitudinal gradient) geographic scales in north-western Europe. New data from Denmark were combined with data from previously studied Fennoscandian and western populations. We related patterns of nuclear vari

Retarded sorption in wood : experimental study, analyses and modeling

Models of moisture flow processes in wood are normally based on a Fickian approach. In many instances, there are considerable discrepancies between modelling and experimental results. It is shown in this thesis that a major cause for these discrepancies is a so-called retarded sorption which is not accounted for in conventional theories. This retarded sorption occurs in the wood cell wall. A spec

Potential and utilization of thermophiles and thermostable enzymes in biorefining

In today's world, there is an increasing trend towards the use of renewable, cheap and readily available biomass in the production of a wide variety of fine and bulk chemicals in different biorefineries. Biorefineries utilize the activities of microbial cells and their enzymes to convert biomass into target products. Many of these processes require enzymes which are operationally stable at high te

Bed agglomeration problems in fluidized-bed biomass combustion

Bed material agglomeration was studied experimentally in a fluidized-bed biomass combustor, Four biomass fuels, four bed materials, three bed additives, and three NOx additives were tested in a temperature range of 670-870 degreesC and at two pressure levels of 1.0 and 1.5 MPa. Two types of agglomeration were observed, a homogeneous and a heterogeneous type. The first occurred at low temperature a

A randomised study in all cervical hip fractures Osteosynthesis with Hansson hook-pins versus AO-screws in 199 consecutive patients followed for two years

A consecutive series of patients with all types of cervical hip fracture (both undisplaced and displaced) were randomised to osteosynthesis with Hansson hook-pins (n = 98) or AO-screws (n = 101). Background parameters, fracture type and reduction of the fracture did not differ significantly between the groups. Fifty-seven percent of the patients were operated on within 6 h of admission to hospital