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Metachromatic leukodystrophy (MLD) is a rare autosomal recessive lysosomal storage disorder caused by disease-causing variants in the gene coding for arylsulfatase A, leading to deficient enzyme activity and subsequent accumulation of sulfatides. MLD is characterized by demyelination and neurodegeneration of the central and peripheral nervous system, manifesting as progressive motor and cognitive
In the last decade, with the growing demand for efficient and more sustainable products that reduce our CO2 footprint, progresses in Additive Manufacturing (AM) have paved the way for optimized heat exchangers, whose disruptive design will heavily depend on predictive numerical simulations. Typical AM rough surfaces show limited resemblance to the artificially constructed rough surfaces that have
In many civil engineering problems, soil is stabilized by a combination of binders and water. The success of stabilization is evaluated using seismic tests with measured P-wave velocities. Optimization of process, laboratory testing and data modelling are essential to reduce the costs of the industrial projects. This paper reports the optimized workflow of soil stabilization through evaluated effe
The safety and pharmacokinetics of carbetocin, a long-acting oxytocin analogue, were studied in 25 healthy nonpregnant women. The distribution and elimination half-lives of a 0.4-mg intravenous dose were found to be 5.5 ± 1.6 minutes and 41 ± 11.9 minutes, respectively. Similarly, the half-lives of a 0.8-mg intravenous dose were found to be 6.1 ± 1.2 minutes and 42.7 ± 10.6 minutes. Approximately
This thesis covers a set of methods related to machine perception and localization, which are two important building blocks of artificial intelligence. In Paper I, we explore the concept of regression via classification (RvC), which is often used for perception tasks where the target variable is either ordinal or when the distance metric of the target space is not well-suited as an objective funct
Background: There is no consensus or clinical guidelines for screening routines of autoimmune disease in individuals with juvenile idiopathic arthritis (JIA), since results are conflicting whether the risk for such conditions is increased or not among individuals with JIA. The aim of this study was to investigate if the frequency of comorbid autoimmune conditions is increased after JIA diagnosis i
Background: High gluten and low dietary fiber in pregnancy intake is associated with an increased risk of celiac disease (CeD) in the child. Early life higher dietary quality is suggested to reduce the subsequent risk of CeD. Objectives: The aim was to investigate associations of pregnancy dietary quality and diversity with child risk of CeD. Methods: In The Norwegian Mother, Father and Child Coho
A new efficient synthesis method of angular selective surfaces (ASSs) based on the accurate equivalent circuit model is proposed. The angular dispersion of different components under oblique incidence is modeled by virtual lumped elements in the angular domain. The processes of obtaining the equivalent circuit for substrates, electrically small grids and patch arrays are presented in detail. The s
Industrial biotechnology has been defined as the use and application of biotechnology for the sustainable processing and production of chemicals, materials and fuels. It makes use of biocatalysts such as microbial communities, whole-cell microorganisms or purified enzymes. Although biocatalysts are considered advantageous, since they operate under mild conditions regarding temperature and pH and e
Bangladesh became an independent country in 1971 and enforced a democratic governance system in 1991. The country has been witnessing a fairly steady economic and social growth processes during the past two decades. However, the political system in the country has not been seeing the same type of development. During four out of eight years in the time period 2001-08 Bangladesh was considered to be
Forests are vital ecosystems that support biodiversity, regulate climate, and provide economic and social value. Their resilience is strongly influenced by harvesting methods, with selective cutting and rotation forestry having noticeably different impacts on carbon dynamics. Understanding these effects requires accurate data on the number and location of felled trees. Although modern harvesters c
Samhället idag kännetecknas av digital interaktion, där både privata såväl som yrkesmässiga kontakter sker via olika tekniska plattformar. Människor skrol-lar, kommunicerar och tar till sig information via mobiltelefoner eller datorer vilket har blivit det normala sättet att interagera i vardagen. Allt fler rättsområ-den har tagit digitaliseringen i beaktning, men det finns fortfarande rättsområ-dSociety today is characterized by digital interaction, with both private and pro-fessional contacts taking place through various technological platforms. Peo-ple browse, communicate and absorb information via mobile phones or com-puters, which has become the normal way of interacting in everyday life. More and more areas of law have taken digitalization into account, but there are still areas of l
I Sverige måste man som utgångspunkt samtycka till all hälso- och sjukvård. Det förutsätter att man har beslutsförmåga vilket för patienter med demens-sjukdom inte alltid är fallet. Tydliga regler för hur vård ska ges till patienter som inte har förmågan att samtycka och bestämma över sin vård saknas i Sverige. Denna framställning uppehåller sig kring denna problematik. Uppsatsen syfte är att undIn Sweden, consent is required for all health care. This requires the ability to make decisions, which is not always the case for patients with dementia. Clear rules on how care should be provided to patients who do not have the capacity to consent and decide on their care are lacking in Sweden. This presentation focuses on this problem. The aim of the paper is to examine the right to health of p
Novel circuit design and manufacturing methodologies are emerging into the market. Heterogeneous Integration allows for chiplet technologies of different process nodes to be combined in one large package. To allow for seamless communication between them, a definition of standards is necessary, and so is the construction of interconnects that follow them. In this thesis, we present an offload engin
Det har hävdats att den teoribildning rörande beslutsfattande under osäkerhet som utvecklats främst inom matematiken, men även inom den ekonomiska vetenskapen bland andra, med fördel skulle kunna inkorporeras även i den juridiska disciplinen. I första hand är det i detta sammanhang Bayes sats som avses, och denna sats tillämplighet på juridiska spörsmål. Detta började diskuteras på allvar mot slutThere have been claims put forth which aims at proving that the theories developed within mathematics, but also within economics to name one, regarding decision making and fact finding would suit very well to be adopted into the legal decision making as well. It is in this context primarily Bayes’ theorem which is referred and mentioned theorems compatibility with law. One of the first articles re
Misshandel är ett begrepp vi i allmänhet förknippar med allvarligt våld mot en, helt eller delvis, försvarslös part. Våld mot den enskilde är en gärning som kriminaliserats i lag då samhället ser den som klandervärd både i Sverige och Danmark. Rättsordningen har till syfte att skydda den enskildes intresse, och i vissa fall till och med skydda den enskilde från sig själv. Det man ofta inte tänker Assault is a concept we generally associate with serious violence against a, wholly or partly, defenceless party. Violence against an individual is an act the society has criminalized because of the danger and effect it can have on the party concerned. The purpose of the legal system is to protect the individual´s interest, and in some cases even protecting the individual from himself. Even if the
Transposable elements (TEs) are genetic entities that have the ability to move around the genome and regulate nearby genes. Therefore, they constitute a potential threat (and sometimes an evolutionary advantage) for the host's genome. Among other regulatory activities, DNA methylation and KRAB-ZNF are responsible for TE silencing. The dysregulation of these silencing mechanisms have been studi
