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Popular Abstract in Swedish Kritiskt sjuka patienter på intensivvårdsavdelningar (IVA) har ofta störningar i blodets levringsförmåga (koagulation). Kliniska tecken som blodpropp (djup ventrombos eller blodpropp i lungorna) och/eller blödning kan vara resultatet av aktivering och konsumtion av koagulationsfaktorer och koagulationshämmare. Disseminerad intravaskulär koagulation (DIC, som är en samtiCritically ill patients in intensive care units (ICU) often have coagulation disturbances. Clinical manifestations such as thromboembolism and/or bleeding may result from activation and consumption of coagulation factors and inhibitors. Disseminated intravascular coagulation (DIC) is a severe condition with an often-poor prognosis. Global haemostatic tests are inexpensive, widely available, and ma

Popular Abstract in Swedish Avregleringen av elmarknaden uppmuntrar kraftbolag och oberoende kraftproducenter till att driva sina kraftverksanläggningar på ett marknadsorienterat sätt. För att behålla de ekonomiska marginalerna på plussidan så har de mest populära åtgärderna varit att förbättra elverkningsgraden genom ändringar i hårdvaran samt höja totalverkningsgraden genom till exempel samproduThe deregulation of the electricity market drives utilities and independent power producers to operate heat and power plants as profit centers. In order to keep the economic margins on the credit side, the preferred measures have been to improve the electrical efficiency through changes in the hardware and boost the overall efficiency through e.g. combined heat and power (CHP) generation. The bett

Background Analysis of the Swedish Farmacotherapy (Swefot) trial at 12 months showed that the addition of an anti-tumour-necrosis-factor agent gave an improved clinical outcome compared with the addition of conventional disease-modifying antirheumatic drugs in patients with methotrexate-refractory early rheumatoid arthritis. Here we report the 2 year follow-up assessment. Methods In this randomise

OBJECTIVE: The influence of the gastrointestinal (GI) microflora in patients with irritable bowel syndrome (IBS) has not been clearly elucidated. This study was undertaken to see if patients with IBS have an imbalance in their normal colonic flora, as some bacterial taxa are more prone to gas production than others. We also wanted to study whether the flora could be altered by exogenous supplement

Background: Optimisation of dopaminergic therapy may alleviate fluctuation-related pain in Parkinson’s disease (PD). Opicapone (OPC) is a third-generation, once-daily catechol-O-methyltransferase inhibitor shown to be generally well tolerated and efficacious in reducing OFF-time in two pivotal trials in patients with PD and end-of-dose motor fluctuations. The OpiCapone Effect on motor fluctuations

Galactic Archaeology is the study of the formation and evolution of the Milky Way through the properties of stars and stellar populations. The combination of stellar ages, chemical compositions, positions, and velocities can reveal the history of star formation and chemical enrichment in different regions of the Galaxy. A large number of stellar spectroscopic, photometric, and astrometric surveys

BACKGROUND: Critically ill newborn infants undergo a variety of painful procedures or experience a variety of painful conditions during their early life in the neonatal unit. In the critically ill paediatric and neonatal population, clonidine is prescribed as an adjunct to opioids or benzodiazepines aiming to reduce the doses of these drugs that are required for analgesia or sedation, or to facili

Popular Abstract in Swedish Varje vecka firar ett stort antal människor gudstjänst i Svenska kyrkan. Vid varje enskild gudstjänst bildas en sorts gemenskap. Men vad är egentligen en gudstjänstgemenskap, hur kan den förstås sociologiskt och teologiskt, vilken ställning har den i Svenska kyrkan och vilken ställning borde den ha? Gudstjänstgemenskaper i Svenska kyrkan i dag kan beskrivas som öppna, iThe dissertation examines the theoretical identity and formal status of a worship community within the Church of Sweden. Two theoretical perspectives form the basis of the investigation. The first is that the identity of the church cannot be reduced to an abstract idea of its essential nature, but what is said about the church must refer to the actual people who belong to it, especially those who

Background: The benefits of exercise in mild and moderate knee or hip osteoarthritis (OA) are apparent, but the evidence in severe OA is less clear. We recently reported that neuromuscular training was well tolerated and feasible in patients with severe primary hip or knee OA. The aims of this controlled before-and-after study were to compare baseline status to an age-matched population-based refe

The rationale for thrombolysis, the most promising pharmacological approach in acute ischaemic stroke, is centred on the principal cause of most ischaemic strokes: the thrombus that occludes the cerebral artery, and renders part of the brain ischaemic. The occluding thrombus is bound together within fibrin. Fibrinolysis acts by activation of plasminogen to plasmin; plasmin splits fibrinogen and fi

Aims. The nature of the thick disc and its relation to the thin disc is presently an important subject of debate. In fact, the structural and chemo-dynamical transition between disc populations can be used as a test of the proposed models of Galactic disc formation and evolution. Methods. We used the atmospheric parameters, [alpha/Fe] abundances, and radial velocities, which were determined from t

Popular Abstract in English Huntingtons sjukdom (HS), även kallad danssjukan, är en ärftlig och dödlig sjukdom som leder till ofrivilliga motoriska rörelser. Personer med HS får vanligtvis symtom i medelål- dern och avlider efter 15–20 år. Diagnosen ställs klinisk när de första ofrivilliga rörelserna uppträder. Dessa symtom kan kopplas till celldöd i de delar av hjärna som styr vår rörelse. SjukdoHuntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. The hypothalamus is an area in the brain involved in the regulation of emotions and m

Objective: Transcatheter valve-in-valve implantation has emerged as an option, in addition to reoperative surgical aortic valve replacement, to treat failed biologic heart valve substitutes. However, the clinical experience with this approach is still limited. We report the comprehensive experience of transcatheter valve-in-valve implantation in the Nordic countries from May 2008 to January 2012.

The heterogeneous group of T-cell lymphomas consist mostly of aggressive diseasess, with generally unfavourable outcome compared to aggressive B-cell lymphomas following similar therapy. This thesis focus on outcome and risk factors for inferior survival, in an unselected population-based cohort of T-cell lymphoma patients. In the first study, outcome of the precursor malignancy T-cell Lymphoblast

BACKGROUND: Radioiodine (131I) has been used in thyroid cancer treatments for many years, and has demonstrated good results with regards to disease management. Radioiodine therapy is however partially empirical, as not very much is known concerning radiation dosimetry. At Skåne University Hospital, the number of treatments has been growing steadily over the past couple of years, resulting in an in

Mål om krigsförbrytelser är en relativt ny företeelse i svenska domstolar och utgör ofta typexempel på vad som kan betraktas som stora brottmål. Inte sällan föregås handläggningen av långa förundersökningar, till följd av komplex och svårutredd brottslighet, vilket leder till att processmaterialet blir mycket omfattande. Detta får till följd att dessa mål binder upp rättsväsendets och parternas reWar crime cases are a relatively new phenomenon in Swedish courts and often serve as a typical example of what can be considered major criminal cases. Often the proceedings are preceded by lengthy preliminary investigations due to crimes being complicated and hard to investigate, resulting in significant amounts of trial material. Consequently, these cases tie up the resources of the judiciary and

I samband med att den nya höghastighetsjärnvägen mellan Stockholm och Göteborg/Malmö planeras, har regeringen utsett ett antal personer från regeringskansliet som ska förhandla om medfinansieringslösningar för byggnationen. ”Sverigeförhandlingen” har även fått i uppdrag av regeringen, att ta fram ett lagförslag för hur fastighetsägare, som gynnas av offentliga investeringar, frivilligt ska kunna åIn connection with the planned high-speed rail links between Stockholm and Gothenburg / Malmö, the government has appointed a committee to negotiate a co-financing solutions for the project. This group, Sverigeförhandlingen, was also commissioned by the government to draw up a bill for how property owners, who benefit from public investment, could voluntarily return parts of this value increase ba

Det sen-Triassiska massutdöendet (STM) var ett av de fem stora massutdöenden i Fanerozoikum och inträffade för omkring 201 miljoner år sedan. Forskningen är enig om att utdöendet orsakades av vulkanutbrotten associerade med bildandet av den Centralatlantiska magmatiska provinsen (CAMP), som är kopplade till uppbrottet av superkontinenten Pangea. De omfattande vulkaniska utsläppen av CO2 och SO2 leThe end-Triassic mass extinction (ETE) was one of the five big mass extinctions of the Phanerozoic and occurred ~201 Ma ago. Research agrees that the main triggering factor for the ETE was the eruptions of the Central Atlantic Magmatic Volcanic Province (CAMP), linked to the break-up of the supercontinent Pangaea. The large amounts of CO2 and SO2 released from the volcanic eruptions had a series o

En utökning av EU:s medlemsstaters nationella koncernbeskattningssystem till att även inkludera gränsöverskridande aktiviteter har under en lång tid varit uppe för debatt inom den Europeiska Unionen. Den Europeiska Kommissionen har presenterat kommunikationer och utkast till direktiv som syftar till att harmonisera de nationella reglerna på området, framförallt i förhållande till utjämning av förlThe extension of Member States domestic group taxation schemes to also involve cross-border activities has for long been debated within the European Union. The European Commission has put forward various communications and draft directives in order to harmonize the national laws in that area, in particular in relation to relief of losses occurred at a subsidiary resident in a state other than its

Popular science summary Do metformin and phenformin cause toxicity to mitochondria of human blood cells? Metformin and phenformin are anti-diabetic drugs associated with lactic acidosis as a rare side effect. This side effect is thought to be due to drug-induced mitochondrial dysfunction. In this project, the mitochondrial toxicity of metformin and phenformin was assessed in human blood cells. I