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Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly
Abstract not available.
Pufendorfinstitutet är ett tvärvetenskapligt institut med syfte att stimulera till samarbete mellan forskare från olika discipliner inom Lunds universitet. I "Teman" och" Advanced Study Groups" ges forskare från alla universitetets fakulteter möjlighet att tillsammans utforska vetenskapliga problem .The Pufendorf Institute for Advanced Studies is an interdisciplinary institute with the aim to stimulate collaboration between researchers from different disciplines within Lund University. In "Themes" and "Advanced Study Groups", researchers from all faculties of the university are given the opportunity to jointly explore scientific issues.
OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>
Objective Blood cell populations, including red blood cells (RBC) unique to the extremely preterm (EPT) infant, are potentially lost due to frequent clinical blood sampling during neonatal intensive care. Currently, neonatal RBC population heterogeneity is not described by measurement of total haemoglobin or haematocrit. We therefore aimed to describe a subpopulation of large RBCs with hyper high
