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Variable selection properties of procedures utilizing penalized-likelihood estimates is a central topic in the study of high-dimensional linear regression problems. Existing literature emphasizes the quality of ranking of the variables by such procedures as reflected in the receiver operating characteristic curve or in prediction performance. Specifically, recent works have harnessed modern theory
Body-focused repetitive behavior disorders, including trichotillomania (hair-pulling disorder) and excoriation (skin picking) disorder, typically emerge in early adolescence, but little is known about the clinical characteristics and treatment outcomes of these disorders in young people, particularly in real-world clinical settings. Participants were 63 children and adolescents (51 girls; age rang
With ongoing climate change, aridity is increasing worldwide, affecting biodiversity and ecosystem function in drylands. However, how the depth-profile microbial community structure and metabolic limitations change along aridity gradients are still poorly explored. Here, 16S rRNA and ITS amplicon sequencing and ecoenzymatic stoichiometry analysis were used to investigate both bacterial and fungal
Background and Purpose: Target delineation in glioblastoma is still a matter of extensive research and debate. This guideline aims to update the existing joint European consensus on delineation of the clinical target volume (CTV) in adult glioblastoma patients. Material and Methods: The ESTRO Guidelines Committee identified 14 European experts in close interaction with the ESTRO clinical committee
Objective Longitudinal clinical registry-infrastructures such as Anti-Rheumatic Therapies in Sweden (ARTIS) allow simultaneous comparison of the safety of individual immunomodulatory drugs used in clinical practice, with consistent definitions of treatment cohorts, follow-up and outcomes. Our objective was to assess and compare incidence rates of key safety outcomes for individual targeted synthet
Part II of the European clinical guidelines for Tourette syndrome and other tic disorders (ECAP journal, 2011) provides updated information and recommendations for psychological interventions for individuals with tic disorders, created by a working group of the European Society for the Study of Tourette Syndrome (ESSTS). A systematic literature search was conducted to obtain original studies of ps
BACKGROUND: Although most pediatric radial neck fractures can be treated with either immobilization alone or closed reduction and immobilization, a small subset result in permanent loss of motion despite surgical management. We sought to characterize the most problematic fractures and correlate final outcomes with both presenting fracture characteristics and the reduction achieved through surgical
Background: Despite newer treatments with immunosuppressive agents, there still exists a considerable morbidity and mortality risk among patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Since 1994 the European Vasculitis Society (EUVAS) has aimed for an improved outcome for patients with AAV, conducting several prospective randomized controlled trials (RCTs).
An important part of responsible business practices is compliance with the law. This article details what actually happens when the laws of the host country fail to ensure adequate protection. The focus here is on land dispossession and loss of livelihood in relation to a gold mine project in central Ghana. How is it that a well-known international company—Newmont—with its own corporate social res
Objectives. We investigated whether comorbidity burden of comatose survivors of out-of-hospital cardiac arrest (OHCA) affects outcome and if comorbidity modifies the effect of target temperature management (TTM) on final outcome. Design. The TTM trial randomized 939 patients to 24 h of TTM at either 33 or 36 °C with no difference regarding mortality and neurological outcome. This post-hoc study of
Magnetic compass orientation in birds has been shown to be light dependent. Results from behavioural studies indicate that magnetoreception capabilities are disrupted under light of peak wavelengths longer than 565 nm, and shifts in orientation have been observed at higher light intensities (43-44x1015 quanta s-1 m-2). To investigate further the function of the avian magnetic compass with respect
Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association, between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. O
Dammar som samlar fosfor Jordbruksinformation 11-2010 2 Text: Katarina Börling Omslagsfoto: Katarina Börling Grafisk form: Holmbergs i Malmö AB 3 Inledning Denna broschyr vänder sig till dig som funderar på att anlägga en damm som samlar fosfor. Här hittar du information om vad du ska tänka på innan du börjar, praktiska råd kring hur dammen ska anläggas och en presentation av tidigare erfarenheter
https://www.nateko.lu.se/sites/nateko.lu.se/files/jordbruksverket_11-2010_0.pdf - 2026-05-23
Nya byggnormer – smartare tunnlar? Cut-and-Cover-tunnlar är vanliga vid grund anläggningsnivå i svensk infrastruktur. Dessa betongkonstruktioner utsätts för konstant vattentryck, vilket ställer krav på sprickkontroll. Sprickor uppstår ofta på grund av tvångslaster, exempelvis från temperaturvariationer och krympning, när dessa deformationer hindras av omgivningen. För att begränsa sprickbildning dTunnel structures play an important role in Sweden’s infrastructure. At shallow depths, a common construction method is the so-called “Cut-and-Cover” tunnel, where the tunnel placement is excavated, cast in concrete on-site, and then backfilled. Such tunnels are typically subjected to constant water pressure, which yields high demands on crack control. Cracking in elongated concrete structures oft
Jaboticaba (Plinia jaboticaba) is an underutilized Brazilian berry and a source of dietary fiber, cyanidin-3-O-glucoside, and ellagic acid derivatives. Non-clinical studies have shown the potential of jaboticaba to alleviate insulin resistance, low-grade inflammation, and obesity-related cognitive decline, although clinical evidence remains limited. A clinical study was conducted to investigate wh
Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining 1 . HR supresses tumorigenesis 1 , but is restricted to the S and G2 phases of the cell cycle when a sister chromatid is present 2 . Breast cancer type 1 susceptibility protein (BRCA1) promotes HR by antagonizing the anti-resection factor TP53-binding prote
Fluorescence microscopy is an effective tool for imaging biological samples, yet captured images often contain noises, including photon shot noise and camera read noise. To analyze biological samples accurately, separating background pixels from signal pixels is crucial. This would ideally be guided by the knowledge of a parameter called the Poisson parameter, 𝜆bg, representing the mean number of
BACKGROUND: Child abuse continues to pose a significant threat to children's health. The repercussions of abuse are profound, impacting the child's physical, social, and emotional well-being, with potential long-term effects that may extend into adulthood. To assist in identifying health concerns in children associated with exposure to physical abuse, a health questionnaire was developed to be use
Uppsatsen utgår från spänningen mellan en enhetlig avtalstolkningslära eller att låta branschspecifika omständigheter och principer styra avtalstolkning. Fokus ligger på upphovsrättsliga överlåtelse- och upplåtelseavtal, där specifikationsprincipen länge har förordat en restriktiv tolkning till upphovsmannens förmån, och där endast det som uttryckligen angetts i avtalet, ska anses ha överlåtits elThe thesis explores the tension between a unified doctrine of contract interpretation or an approach that allows sector-specific circumstances and principles to influence the interpretation of contracts. The primary focus of this analysis is on copyright transfer and licensing agreements, where the principle of specification has long supported a restrictive interpretation in the author’s interest,
