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Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining 1 . HR supresses tumorigenesis 1 , but is restricted to the S and G2 phases of the cell cycle when a sister chromatid is present 2 . Breast cancer type 1 susceptibility protein (BRCA1) promotes HR by antagonizing the anti-resection factor TP53-binding prote
Fluorescence microscopy is an effective tool for imaging biological samples, yet captured images often contain noises, including photon shot noise and camera read noise. To analyze biological samples accurately, separating background pixels from signal pixels is crucial. This would ideally be guided by the knowledge of a parameter called the Poisson parameter, 𝜆bg, representing the mean number of
Abstract Purpose: The purpose of this paper is to investigate the key factors that contribute to the success of corporate apologies issued in response to a crisis. Methodology: This paper uses a qualitative research method. The primary data was collected in the form of case studies of 30 apologies across three decades and multiple industries. These cases were analyzed using relevant theories foun
Dupljaja loess-palaeosol sequence in southeasternmost sector of the Banat Loess Plateau (Serbia), situated in the southeastern Carpathian (Middle Danube) Basin, is important for understanding the evolution of the Last Glacial climate and southeastern Carpathian as a potential corridor for human migration throughout Europe. The Dupljaja loess-palaeosol sequence in the southeasternmost sector of the
BACKGROUND: Child abuse continues to pose a significant threat to children's health. The repercussions of abuse are profound, impacting the child's physical, social, and emotional well-being, with potential long-term effects that may extend into adulthood. To assist in identifying health concerns in children associated with exposure to physical abuse, a health questionnaire was developed to be use
Tattoo ink on the European market has been reported to contain many human toxicants, which has raised concerns about health effects. Clarifying the exposure distribution in the population is key to understanding potential public health implications. We investigated the prevalence of tattoos in a population-based Swedish cohort of 13 046 individuals aged 20–68 years with exposure data collected thr
MAX IV Laboratory, inaugurated in 2016, is a Swedish national synchrotron radiation facility that presently has 16 beamlines in operation. MAX IV consists of three accelerators with different characteristics. The 3 GeV storage ring is the world’s first fourth-generation ring and pioneered the use of the multibend achromat lattice to produce ultrahigh brightness X-rays. MAX IV is the continuation o
Uppsatsen utgår från spänningen mellan en enhetlig avtalstolkningslära eller att låta branschspecifika omständigheter och principer styra avtalstolkning. Fokus ligger på upphovsrättsliga överlåtelse- och upplåtelseavtal, där specifikationsprincipen länge har förordat en restriktiv tolkning till upphovsmannens förmån, och där endast det som uttryckligen angetts i avtalet, ska anses ha överlåtits elThe thesis explores the tension between a unified doctrine of contract interpretation or an approach that allows sector-specific circumstances and principles to influence the interpretation of contracts. The primary focus of this analysis is on copyright transfer and licensing agreements, where the principle of specification has long supported a restrictive interpretation in the author’s interest,
Purpose: The PET Response Criteria in Solid Tumours (PERCIST) 1.0 provides a standardized framework for evaluating treatment response using [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography – computed tomography (PET-CT), but its clinical use is hindered by manual complexity. This study presents coPERCIST, an artificial intelligence (AI)-assisted module integrated into the RECOMIA pl
Interneurons have been found to be important for normal cognitive function. Impairments to their growth or signaling have been indicated to be involved in the development of schizophrenia, autism and epilepsy. Defective functioning in GABA:ergic interneurons has been linked to undesired desynchronous firing in neural signals as a consequence of these interneurons firing too infrequently or not at
I Sverige vänds omkring 50.000 barns liv upp och ner varje år, när deras föräldrar väljer att gå skilda vägar. Det som en gång varit barnets trygghet och hela värld, rivs upp och känns istället skrämmande och otryggt. Föräldrarnas viljor och känslor styr processen, vilket gör att barnen allt som ofta hamnar i kläm. I en majoritet av fallen löser föräldrarna barnets boende, vårdnad och umgänge gemeIn Sweden the lives of about 50.000 children are turned upside down every year, just because their parents have choosen to separate. What has once been the childs secure and safe world, are now ripped apart and frightening instead. The wills of the parents and their emotions, can greatly impact the decisions of the jucidial process which can in turn have a catasprohic backlash on the child. In the
Abstract in Undetermined Assume that in periods with stochastic demand remain until the next replenishment arrives at a central warehouse. How should the available inventory be allocated among N retailers? This paper presents a new policy and a new lower bound for the expected cost of this problem. The lower bound becomes tight as N -> infinity. The infinite horizon problem then decomposes into N
Objective: To evaluate the safety, adherence, and efficacy of self-administered balance and resistance exercise using the Borg scale in patients with chronic kidney disease, and to examine relationships between exercise intensity or duration and baseline measures, and relationships between change in physical performance and baseline measures, intensity, or duration. Design: Post-hoc analysis of a
INTRODUCTION: This study aimed to adapt the Short Digital Stress Scale (SDSS) into Turkish and to evaluate its psychometric properties in an adult population. Digital stress has become increasingly relevant with the widespread and continuous use of digital technologies, highlighting the need for valid and reliable instruments across cultural contexts.METHODS: A total of 276 adults (72.8% female, 2
Mild traumatic brain injury (mTBI) is a frequent but underreported consequence of professional cycling crashes, yet current helmet testing standards primarily simulate head-first impacts, and their representation of real-world head impact scenarios is unclear. This study explores crash typology of professional cycling crashes involving head-ground contact through systematic video analysis of 128 h
Seasonality is a core aspect of life in West African artisanal fishing communities, with fisherfolk having long adapted to bumper and lean fishing seasons. In an attempt to tackle dwindling fish stocks, however, the Government of Ghana introduced a month-long closed fishing season. This paper explores the ways in which fishing communities, which are accustomed to seasonal change, make sense of and
Artificial intelligence (AI) is frequently described as a strategic resource for marketing, yet empirical insights into how AI is adopted and used in business-to-business (B2B) marketing remain limited. Prior research has predominantly focused on technological capabilities or consumer-oriented contexts, while organizational and strategic considerations in B2B firms have received less attention. Th
Winter is a critical bottleneck period for many insects and is particularly pivotal for pest species, being a major regulator of their populations. In winter, insect fruit pests such as the invasive fly, Drosophila suzukii, not only have to cope with harsh environmental conditions but also need to find alternative resources when cultivated fruit are scarce. This study aimed to disentangle the rela
Full text linksBMC Public Health. 2026 Apr 17;26(1):1273.doi: 10.1186/s12889-026-27378-1.Individual and environmental determinants of body mass index trajectories: results from a longitudinal study in Southern SwedenPauline Rebouillat 1 , Kristoffer Mattisson 2 , Giedre Gefenaite 3 , Per-Olof Östergren 4 , Peter M Nilsson 5 6 , Jonas Björk 2 7Affiliations PMID: 41998602 PMCID: PMC13091265 DOI: 10.
