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In patients with severe haemophilia, spontaneous bleeding into joints initiates a sequence of events culminating in disabling arthropathy. Early evidence from Sweden suggested that clotting factor prophylaxis improved patient outcomes. Recent randomized, controlled trials comparing prophylaxis with on-demand treatment have definitively shown that prophylaxis reduces bleeding and improves joint out

Though proliferation has repeatedly shown a prognostic role in sarcomas, it has not reached clinical application. We performed a comprehensive evaluation of the prognostic role of 5 proliferation measures in a large series of soft tissue sarcomas of the extremities and the trunk wall. One hundred ninety-six primary soft tissue sarcomas of the extremities and the trunk wall were subjected to DNA fl

Dose conversion coefficients attempt to harmonize the material-, location-, and exposure-dependent results from retrospective dosemeters. The issues and uncertainties arising from dose conversion are explored within the framework of an interlaboratory comparison exercise in which mobile phones were positioned around anthropomorphic phantoms and exposed to non-uniform photon fields, with the glass

LTx remains the definitive treatment for end-stage lung disease, but the increasing demand for donor lungs outpaces the available supply. This chapter explores innovative approaches to expand the pool of viable donor lungs and reduce waiting times, which is crucial to lowering mortality rates among patients on transplant lists. Xenotransplantation, which has made its greatest strides using porcine

Comparative genomic analysis often involves visualization of alignments of genomic loci. While several software tools are available for this task, ranging from Python and R libraries to stand-alone graphical user interfaces, a tool is lacking that offers fast, automated usage and the production of publication-ready vector images. Here we present LoVis4u, a command-line tool and Python API designed

The problem: wearable eye trackers deliver eye-tracking data on a scene video that is acquired by a camera affixed to the participant’s head. Analyzing and interpreting such head-centered data is difficult and laborious manual work. Automated methods to map eye-tracking data to a world-centered reference frame (e.g., screens and tabletops) are available. These methods usually make use of fiducial

Oceanic islands have isolated biota, which typically include many endemic species. However, island endemics are vulnerable due to small population sizes, and they are often threatened by habitat destruction or by introduced pests and predators. Adequate conservation planning requires good information on genetic variability and population structure, also when seemingly viable species are considered

The global energy demand is increasing due to an increase in economic growth and urbanization which is set to rise by 4.6% in 2021. A major part of this increasing energy demand is accomplished by fossil fuels which create environmental pollution. Hydropower is the most mature, reliable, and cost-effective source of energy. However, the operation and maintenance (O&M) of hydro turbines is the

Due to the COVID-19 outbreak, industries have gained a thrust on contactless processing for computing technologies and industrial automation. Cloud of Things (CoT) is one of the emerging computing technologies for such applications. CoT combines the most emerging cloud computing and the Internet of Things. The development in industrial automation made them highly interdependent because the cloud c

Background and Objectives: Cancer biomarkers provide information on the characteristics and extent of cancer progression and help inform clinical decision-making. However, they can also play functional roles in oncogenesis, from enabling metastases and inducing angiogenesis to promoting resistance to chemotherapy. The resulting evolution could bias estimates of cancer progression and lead to subop

Foaming of most bio-based polymers is challenged by low pore formation and foam stability. At the same time, the developing utilization of bio-based materials for the circular economy is placing new demands for easily processable, low-density materials from renewable raw materials. In this work, we investigate cellulose nanofiber (CNF) foams in which foaming is facilitated with wood-based hemicell

Advanced cancer, with its considerable physical symptoms and psychosocial burdens, represents an existential threat and major stressor to patients and their caregivers. In response to such stress, patients and their caregivers use a variety of strategies to manage the disease and related symptoms, such as problem-focused, emotion-focused, meaning-focused, and spiritual/religious coping. The use of

Efficient design of urban drainage systems is based on statistical analysis of past rainfall events at fine time scales. However, fine time scale rainfall data are usually lacking in many parts of the world. A possible way forward is to develop methods to derive fine time scale rain intensities from daily observations. This paper applied cascade-based disaggregation modeling for generation of fine

Aim: To present the utilization of a highly interactive, internet-based, package for ophthalmological content. Summary of work: The clinical ophthalmology rotation in Malmö is a 6 weeks on-campus period integrated with ENT. Weekly interactive internet-based theory parts include, (1) a PBL scenario (pathophysiology and basic sciences), (2) a series of case presentations (management principles), (3)

This small scale study or pilot case looks into how studio audiences participate; as well as how we can characterize the interaction between host and studio audience in political comedy. The case used is "The Daily Show with Jon Stewart" (US), as it is widely popular but also has a following in Europe and Sweden. According to Corner et al (2013), political comedy includes satire, mocking, spoofing

Context: When using the Case Method in teaching situations, problem-solving is emphasized and taught, in order to acquire the skills and later be able to apply them in new situations. The basis of the learning process is the students’ own activity in the situation and is built on critical appraisal and discussion. Objectives: To explain what the Case Method is, what it is not and to describe when

Inbreeding depression may drive the evolution of inbreeding avoidance through dispersal and mate choice. In birds, many species show female-biased dispersal, which is an effective inbreeding avoidance mechanism. In contrast, there is scarce evidence in birds for kin discriminative mate choice, which may, at least partly, reflect difficulties detecting it. First, kin discrimination may be realized

Introduction: Soft tissue knee injury is a well-established and potent risk factor for development of knee osteoarthritis. However, there is a paucity of epidemiological data from the general population. Our aim was to estimate the annual person-level incidence for a wide spectrum of clinically diagnosed soft tissue knee injuries, and their distribution by age, sex, and season. Methods: In Sweden,

Sättet som världen presenterar sig för våra sinnesorgan är genom en kontinuerlig ström av information, men vår upplevelse av den är uppdelad i diskreta händelser. Enligt eventsegmenteringsteorin är den här segmenteringen en inbyggd och automatisk del av mänsklig kognition. Omfattande forskning ger inte bara stöd åt den här teorin utan tyder också på att sättet vi delar upp händelser påverkar vårt The world presents itself to our sense organs as a continuous stream of input, yet we appear to conceive experiences in terms of discrete events. According to event segmentation theory, this segmentation is an intrinsic and automatic component of human cognition. A considerable body of research provides evidence for this claim and suggests further that the way we segment events has consequences fo

It is becoming increasingly common for corporations to seek impact in society alongside profit and it is often argued that corporations should collaborate with startups. By collaborating with impact accelerators, intermediary organisations that support impact startups, corporations can gain access to innovation whilst having a positive impact on society and the environment. The purpose of this s