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Platinum Nanocatalysts Supported on Defective Hollow Carbon Spheres : Oxygen Reduction Reaction Durability Studies

The durability and long-term applicability of catalysts are critical parameters for the commercialization and adoption of fuel cells. Even though a few studies have been conducted on hollow carbon spheres (HCSs) as supports for Pt in oxygen reduction reactions (ORR) catalysis, in-depth durability studies have not been conducted thus far. In this study, Pt/HCSs and Pt/nitrogen-doped HCSs (Pt/NHCSs)

Mucosal cryobiopsies : a new method for studying airway pathology in asthma

Background In vivo studies of airway pathology in obstructive lung disease are limited by poor quality of specimens obtained with forceps. Obtainment of cryobiopsies has increased diagnostic yield in cancer and interstitial lung disease but has not been used in patients with asthma. In a recent pilot study, we found mucosal cryobiopsies to be larger and more intact than conventional forceps biopsi

hnRNP G/RBMX enhances HPV16 E2 mRNA splicing through a novel splicing enhancer and inhibits production of spliced E7 oncogene mRNAs

Human papillomavirus type 16 (HPV16) E2 is an essential HPV16 protein. We have investigated how HPV16 E2 expression is regulated and have identifed a splicing enhancer that is required for production of HPV16 E2 mRNAs. This uridine-less splicing enhancer sequence (ACGAGGACGAGGACAAGGA) contains 84% adenosine and guanosine and 16% cytosine and consists of three 'AC(A/G)AGG'-repeats. Mutational inact

Investigating Ancient Agricultural Field Systems In Sweden From Airborne Lidar Data By Using Convolutional Neural Network

Today, the advances in airborne LIDAR technology provide high-resolution datasets that allow specialists to detect archaeological features hidden under wooded areas more efficiently. Still, the complexity and large scale of these datasets require automated analysis. In this respect, artificial intelligence (AI)-based analysis has recently created an alternative approach for interpreting remote sen

Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits

Cerebellar dysfunction is commonly observed following traumatic brain injury (TBI). While direct impact to the cerebellum by TBI is rare, cerebellar pathology may be caused by indirect injury via cortico-cerebellar pathways. To address the hypothesis that degeneration of Purkinje cells (PCs), which constitute the sole output from the cerebellum, is linked to long-range axonal injury and demyelinat

Long-Read Sequencing Reveals Genetic Adaptation of Bartonella Adhesin A Among Different Bartonella henselae Isolates

Bartonella henselae is the causative agent of cat scratch disease and other clinical entities such as endocarditis and bacillary angiomatosis. The life cycle of this pathogen, with alternating host conditions, drives evolutionary and host-specific adaptations. Human, feline, and laboratory adapted B. henselae isolates often display genomic and phenotypic differences that are related to the express

Local structure of Nb in superconducting Nb-doped Bi2Se3

In the prospect of realizing bulk superconductivity in a topological insulator, metal-doped Bi2Se3 has been investigated with increased interest, where the Cu-, Sr-, and Nb-doped systems appear particularly promising. It is generally assumed that metal intercalation into the van der Waals (vdW) gap is responsible for the superconductivity. We have investigated the local structure of Nb in samples

The GALAH Survey: Chemical Clocks

We present the first large-scale study that demonstrates how ages can be determined for large samples of stars through Galactic chemical evolution. Previous studies found that the elemental abundances of a star correlate directly with its age and metallicity. Using this knowledge, we derive ages for 214 577 stars in GALAH DR3 using only overall metallicities and chemical abundances. Stellar ages a

Rational and efficient ground investigations for industrialised construction of new railways

To complete a new Swedish railway line in a much shorter timeframe than today, alter natives to the traditional methods need to be explored. One option is the use of prefabricated concrete slabs elevated on piers, analogous to the concept used in China for building new railways in record time (He et al., 2017). The method has the advantage of directly tackling the barrier effects exhibited by trad

Concordance of X-ray and AlphaFold2 Models of SARS-CoV-2 Main Protease with Residual Dipolar Couplings Measured in Solution

The 68-kDa homodimeric 3C-like protease of SARS-CoV-2, Mpro (3CLpro/Nsp5), is a promising antiviral drug target. We evaluate the concordance of models generated by the newly introduced AlphaFold2 structure prediction program with residual dipolar couplings (RDCs) measured in solution for 15N-1HN and 13C′-1HN atom pairs. The latter were measured using a new, highly precise TROSY-AntiTROSY Encoded R

Winds of change: An engaged ethics approach to energy justice

Theories of energy justice are standardly used to evaluate decision-making and policy-design related to energy infrastructure. All too rarely attention is paid to the need for a method of justifying principles of justice as well as justice-based judgments that are appealed to in this context. This article responds to this need by offering an engaged ethics approach to normative justification usefu

Fungal communities mediate but do not control leaf litter chemical transformation in a temperate oak forest

Background and Aims: In temperate forests, fungi are the main actors in leaf litter decomposition. Still, we have minimal knowledge of their influence on changes in leaf litter chemistry. Thus, we aimed to determine the main drivers behind leaf litter chemical transformation during decomposition. Methods: We monitored the development of fungal communities, extracellular enzyme activities, and litt