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Background-Sphingosine-1-phosphate (S1P) signaling is a central regulator of resistance artery tone. Therefore, S1P levels need to be tightly controlled through the delicate interplay of its generating enzyme sphingosine kinase 1 and its functional antagonist S1P phosphohydrolase-1. The intracellular localization of S1P phosphohydrolase-1 necessitates the import of extracellular S1P into the intra

The smaller isoform of glutamic acid decarboxylase, GAD65, is an important autoantigen implicated in the pathogenesis of type 1 diabetes whereas the larger isoform, GAD67 appears to play no major role. The primary difference between the two isoforms resides in the N-terminal part of the molecule including the GAD65 membrane-anchoring domain. The aim of this study was to generate mutants of the mem

Estimation of high-resolution terrestrial evapotranspiration (ET) from Landsat data is important in many climatic, hydrologic, and agricultural applications, as it can help bridging the gap between existing coarse-resolution ET products and point-based field measurements. However, there is large uncertainty among existing ET products from Landsat that limit their application. This study presents a

Prolidase is a ubiquitously distributed dipeptidase and the only dipeptidase in humans capable of cleaving the peptide bond preceding the amino acids proline (Pro) or hydroxyproline (Hyp). It is mainly implicated in the degradation of dietary and endogenous proteins. It is also involved in the terminal steps of collagen catabolism by hydrolyzing Pro and Hyp-containing dipeptides. Finally, it is be

Factor V (FV) is a regulator of both pro- and anticoagulant pathways. It circulates as a single-chain procofactor, which is activated by thrombin or FXa to FVa that serves as cofactor for FXa in prothrombin activation. The cofactor function of FVa is regulated by activated protein C (APC) and protein S. FV can also function as an anticoagulant APC cofactor in the inhibition of FVIIIa in the membra

Synthesis of heme A from heme B (protoheme IX) most likely occurs in two steps with heme O as an intermediate. Bacillus subtilis CtaB, an integral membrane protein, functions in farnesylation of heme B to form heme O. CtaA, also a membrane protein, is required for heme A synthesis from heme O and appears to be a monooxygenase and/or a dehydrogenase. Wild-type ctaA and ctaB expressed together from

Monitoring is science keeping our thumb on the pulse of the environment to detect any changes of concern for societies. Basic science is the question-driven search for fundamental processes and mechanisms. Given the firm root of monitoring in human interests and needs, basic sciences have often been regarded as scientifically "purer"-particularly within university-based research communities. We ar

The Mallard (Anas platyrhynchos) is an important reservoir species for influenza A viruses (IAV), and in this host, prevalence and virus diversity are high. Studies have demonstrated the presence of homosubtypic immunity, where individuals are unlikely to be reinfected with the same subtype within an autumn season. Further, evidence for heterosubtypic immunity exists, whereby immune responses spec

Wild birds, particularly duck species, are the main reservoir of influenza A virus (IAV) in nature. However, knowledge of IAV infection dynamics in the wild bird reservoir, and the development of immune responses, are essentially absent. Importantly, a detailed understanding of how subtype diversity is generated and maintained is lacking. To address this, 18,679 samples from 7728 Mallard ducks cap

There is a growing need for selective recognition of microorganisms in complex samples due to the rapidly emerging importance of detecting them in various matrices. Most of the conventional methods used to identify microorganisms are time-consuming, laborious and expensive. In recent years, many efforts have been put forth to develop alternative methods for the detection of microorganisms. These m

B cells produce antibodies, key effector molecules in health and disease. They mature their properties, including their affinity for antigen, through hypermutation events; processes that involve, e.g., base substitution, codon insertion and deletion, often in association with an isotype switch. Investigations of antibody evolution define modes whereby particular antibody responses are able to form

The detection of reactive oxygen species (ROS) after traumatic brain injury (TBI) is based on indirect methods due to the high reactivity and short half-life of ROS in biological tissue. The commonly used salicylate trapping method has several disadvantages making it unsuitable for human use. We have evaluated 4-hydroxybenzoic acid (4-HBA) together with microdialysis (MD) in the rat as an alternat

The fate of carcinogens differs among individuals who have different activities of drug-metabolizing enzymes that are important in activating and detoxifying carcinogens. A drug that profoundly alters the metabolism of the drugs and carcinogens is the anticonvulsive agent phenobarbital. To investigate why epileptic patients appear to have a low risk of cancer of the urinary bladder, and on the bas

Aims: This study investigates the lobbying actors of the food and drink industry (FDI), their web lobbying arguments used in the sugar taxation debate and the tactics deployed when facing legislative restrictions on their products to curb the burden of non-communicable diseases in Europe. Methods: A stakeholder analysis was performed to identify the FDI’s actors lobbying against sugar taxation wit

Dnr U 2016/116 Samhällsvetenskapliga fakulteten A Utbildningsplan för kandidatprogram i samhällsplanering - urban och regional utveckling (Bachelor of Science Programme in Urban and Regional Planning) Omfattning: 180 högskolepoäng Nivå: Grundnivå Programkod: SGSPL Utbildningsplanen är fastställd av dekanus 2013-03-26 enligt samhällsvetenskapliga fakultetens delegationsordning, dnr S2012/60 och rev

https://www.keg.lu.se/sites/keg.lu.se/files/sgspl_utbildningsplan_beslut_2016-03-01.pdf - 2026-06-08

Management of Environmental Product Information By: Angela Billings Lund University Masters in Environmental Science (LUMES) February 2001 Management of Environmental Product Communication 1 1.1 Background ....................................................................................................................................................... 2 1.2 Purpose.............................

https://www.lumes.lu.se/sites/lumes.lu.se/files/billings_angela.pdf - 2026-06-08

PowerPoint Presentation Lund University Faculty of medicine 2025 1 Nine Faculties and several world-leading research fields. 2 Nine faculties in three locations Faculty of Engineering – LTH Faculty of Science Faculty of Law Faculty of Social Sciences Faculty of Medicine Joint Faculties of Humanities and Theology School of Economics and Management Faculty of Fine & Performing Arts Campus Helsingbor

https://www.intramed.lu.se/sites/intramed.lu.se/files/2025-02/Presentation_Faculty_of_Medicine_2025-en.pptx - 2026-06-08

LUNDS U N IVE RS ITET Konstnärliga fakulteten Fakultetsstyrelsen Närvarande ledamöter Närvaro- och yttranderätt Jan Michelsen Almaz Ybeio Amin Zouiten Ida Wachsberger Frånvarande MariaHedh,rnd Kirse JLrnge- Stevnsborg Sofie Lebech Outi Stålhane Sanimir Resió Staffan Storm Håkan Andersson Sven Bjerstedt Henrik Frendin Per Olof Persson ,4se Lugnér Maria Frej Jesper Larsson Moa Lindell Adam Brenthel

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/2021-11/protokoll_kfs_211117.pdf - 2026-06-08

Control of emission by intermolecular fluorescence resonant energy transfer (IFRET) and intermolecular charge transfer (ICT) is investigated with the quantum-chemistry method using two-dimensional (2D) and three-dimensional (3D) real space analysis methods. The work is based on the experiment of tunable emission from doped 1,3,5-triphenyl-2-pyrazoline (TPP) organic nanoparticles (Peng, A. D.; et a