Search results

Video capsule endoscopy (VCE), perfomed by ingesting a small vitamin-sized camera pill, was developed over a period of a couple of decades and –since its introduction in clinical practice at the dawn of the millennium– has become an essential tool in the diagnosis and management of small bowel (SB) diseases. At the same time, other fields such as minimally invasive diagnosis of other parts of the

Diagnostik av cancer avseende typ och ursprung är tillsammans med hur avancerad cancern är och om vissa särskilda tumöregenskaper föreligger de viktigaste faktorerna för val av behandling. Cancer diagnostiseras i de flesta fall med hjälp av mikroskop. Cancer i lunga kan vara svårdiagnostiserad då man ofta har tillgång till begränsad mängd vävnad från provtagning från tumören, och immunhistokemiskaDiagnostics of cancer concerning type and origin is, together with cancer stage and some specific tumor characteristics, the most important factors for treatment selection. Most cancers are diagnosed using a microscope. Pulmonary cancers may be tricky to diagnose as there is often limited tissue to examine from the tumor sampling, and immunohistochemical analyses are often necessary for subtyping

Our research uses advanced technology to generate neurons from novel cell sources with the aim to extensively define the subtype and function of the generated neurons and their potential for therapeutic use in the future. For this we are using reprogramming technology in animal models or human stem cell culture system, together with electrophysiology, RNA sequencing, tracing technologies and cell

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. One of the hallmarks of the disease is a multitude of autoantibodies, indicating a breakdown in self tolerance. The corresponding antigens have been fou

Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl

Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac

Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.

Centre for Innovation Research – CIRCLE – is an interdisciplinary centre which connects innovation researchers from different faculties at Lund University as well as other Swedish and international universities. The meaning of the term innovation has transformed and is now tightly linked to sustainable development goals including climate change, social sustainability and food security. CIRCLE’s a