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https://www.cec.lu.se/staff-pages/finances-and-purchasing/administrative-guide-2025 - 2026-07-05

A unique anti-inflammatory property of IgG, independent of antigen specificity, is described. IgG with modification of the heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-beta-N-acetylglucosaminidase (EndoS) induced a dominant suppression of immune complex (IC)-mediated inflammation, such as arthritis, through destabilization of local ICs by fragment crystallizable-fragment c

This thesis investigates if it is possible to measure the plunger position in a Ledex 282352-023 solenoid actuator without the use of external sensors. To do this, various different methods, all based on comparing the current response to the applied voltage were evaluated from different categories such as calculation time, reliability and distinct position levels. The method that performed best in

Abstract not available

Despite systematic screening and improved treatment strategies, the prognosis remains worse in patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) compared to patients with idiopathic/hereditary pulmonary arterial hypertension (IPAH). We aimed to investigate differences in clinical characteristics, outcome and performance of the European Society of Cardiolo

Video capsule endoscopy (VCE), perfomed by ingesting a small vitamin-sized camera pill, was developed over a period of a couple of decades and –since its introduction in clinical practice at the dawn of the millennium– has become an essential tool in the diagnosis and management of small bowel (SB) diseases. At the same time, other fields such as minimally invasive diagnosis of other parts of the

Diagnostik av cancer avseende typ och ursprung är tillsammans med hur avancerad cancern är och om vissa särskilda tumöregenskaper föreligger de viktigaste faktorerna för val av behandling. Cancer diagnostiseras i de flesta fall med hjälp av mikroskop. Cancer i lunga kan vara svårdiagnostiserad då man ofta har tillgång till begränsad mängd vävnad från provtagning från tumören, och immunhistokemiskaDiagnostics of cancer concerning type and origin is, together with cancer stage and some specific tumor characteristics, the most important factors for treatment selection. Most cancers are diagnosed using a microscope. Pulmonary cancers may be tricky to diagnose as there is often limited tissue to examine from the tumor sampling, and immunohistochemical analyses are often necessary for subtyping

Our research uses advanced technology to generate neurons from novel cell sources with the aim to extensively define the subtype and function of the generated neurons and their potential for therapeutic use in the future. For this we are using reprogramming technology in animal models or human stem cell culture system, together with electrophysiology, RNA sequencing, tracing technologies and cell

Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl

https://www.mhm.lu.se/internt/sites/mhm.lu.se.internt/files/2026-06/La%CC%88sa%CC%8Arso%CC%88versikt_26-27_24.06.26.pdf - 2026-07-06

Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.