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Det finns i detta nu en pågående debatt inom den offentliga upphandlingen kring huruvida det är en för samhället positiv sak att i samband med upphandlingsprocessen ställa krav på att leverantören lever upp till vissa sociala åtaganden. De senaste årens utveckling har resulterat i att EU i allt större utsträckning uppmuntrar upphandlande myndigheter att använda sig av sociala hänsyn i sina upphandThere is, as we speak, an on-going debate within the area of public procurement, about whether the society has something to gain by setting social requirements on suppliers in the procurement process. The last years’ development has resulted in that the EU in a wider range encourage government bodies to take social concerns in public procurement, with the purpose to reach the common goals that the

Popular Abstract in English My PhD thesis has focused on increasing the understanding of the osteoclasts, the cells responsible for degradation of bone, by studying the rare hereditary disease autosomal recessive osteopetrosis (ARO). ARO is present already at birth and is caused by mutations affecting the osteoclasts ability to degrade bone. Non-functional osteoclasts lead to dramatic increases inThis thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed

Basement membranes (BMs) are sheet-like structures of extracellular matrix. They act as a supporting structure but can also significantly influence cellular behavior in development, tissue homeostasis and disease. Laminins, a major BM component, are multidomain proteins, consisting of three polypeptide chains (α, β and γ). During pregastrulation development, stem cells convert and epithelial tissu

Hässleholm Miljö who own the landfill site in Vankiva in southern Sweden are having difficulties in keeping their heavy metal emissions within the limits of their very strict permit. Today reduction is reached by chemical precipitation, but a more effective and environmentally friendly process is wanted. Biological heavy metal removal in leachate water, using sulfate reducing bacteria (SRB) and me

Chocaya Basin ligger i den nordvästra delen av dalen Cochabamba i Bolivia, där ett halvtorrt klimat råder. Den ökande befolkningen är beroende av lokala akviferer för dricksvatten och jordbruk, där brunnar används för att utvinna vattnet. Låg nederbörd, främst under torrperioden, och uppförandet av nya hus eller fabriksbyggnader, påverkar infiltrationen av vattnet i jorden och därmed akviferernas The Chocaya Basin is situated in the north-western part of the Valley of Cochabamba, Bolivia, where a semi-arid climate prevails. The increasing population is dependent on local aquifers for drinking water and irrigation. Wells are used to extract water. Scarce amount of rainfall, mainly during the dry season, and constructions of buildings, are reducing the infiltration of water in the soil and c

Photodynamic therapy (PDT) is an established treatment for actinic keratosis and selected non-melanoma skin cancers. Still, its broader use is limited by pain, skin irritation, and formulation constraints associated with high photosensitiser concentrations. This study aimed to develop and evaluate a Crystalip®-based topical PDT formulation that enables two-step manufacturing, delivers methyl-amino

Med en ökad efterfrågan på hållbara förpackningslösningar för den ständigt växande FMCG-marknaden, uppenbarar sig fiberbaserade system som ett svar på att fasa ut plast i förpackningar och minska vårt klimatavtryck. Att konstruera en förpackningslösning som till stor del består av kartong kommer med sina utmaningar, som att integrera funktioner i kartongen som polymerer tidigare bidragit till. Då With an increased demand for sustainable packaging solutions for the ever-growing FMCG market, fiber-based systems rise as an answer to phasing out plastics in packages and reducing the humanity’s climate footprint. However, constructing a packaging solution largely consisting of paperboard comes with its challenges, such as integrating functionalities in the anisotropic paperboard that formerly w

Title: The thin line between toxic leadership and transformational leadership: stories of Steve Jobs Seminar date: 1 June 2016 Course: FEKH49, Degree Project Undergraduate level, Business Administration, Undergraduate level, 15 University Credit Points (UPC) or ECTS‐cr) Authors: Amanda Bengtsson, Malin Lindskog and Sofia Jörnlid Advisor/s: Sverre Spoelstra Key words: Steve Jobs, Toxic Leadershi

In all living organisms, proteins which transport water and other small solutes across the membrane exist and are known as aquaporins. Aquaporins consist out of four monomers, forming a homo-tetramer with a substrate conducting channel in each monomer. Aquaporins can be regulated by either gating or trafficking, which allows the cell to control the permeability of the membrane. Aquaporin 5 is one

Breast cancer is the most common type of cancer in women and, in Sweden, is the most deadly second only to lung cancer. While treatment and diagnostic options have improved in the past decades and short- to mid-term survival is good, long-term survival is much poorer. On the other hand, many women are likely cured by surgery and radiotherapy alone, but receive unnecessary adjuvant treatment leadin

As semiconducting nanowires have promising applications for materials science, nanoelectronics and photovoltaic devices, absolute control of their structure, morphology and composition is a prerequisite for their functionality. Nanowires, grown through the vapor-liquid-solid (VLS) method, exhibit a complex relationship between their liquid seed particle and what properties, such as the aforementio

De första universiteten i Europa grundades i en tid då samhället var strikt hierarkiskt. Det bestod av sammanslutningar, så kallade korporationer, med olika rättigheter och skyldigheter sinsemellan. Universitetet utvecklades till att bli en sådan korporation. Efterhand tillerkändes vissa korporationer privilegier, inledningsvis av den andliga makten och sedan av den värdsliga. Ett av de privilegieThe first universities in Europe were founded during a time when society was strictly hierarchical. It consisted of various associations, so called corporations, each with their own different rights and obligations. The university developed to become such a corporation. Subsequently, certain privileges were granted certain corporations, at first by the spiritual power and later by the worldly powe

Guidance for managing extensions of doctoral studentships at the Faculty of Social Sciences due to the Covid-19 pandemic Page 1 of 9 Faculty Office MEMO Reg. No. STYR 2021/780 2021-03-18 Guidance for managing extensions of doctoral studentships at the Faculty of Social Sciences due to the Covid-19 pandemic Background For some doctoral students, the Covid-19 pandemic may entail obstacles that make

https://www.sam.lu.se/en/internal/sites/sam.lu.se.en.internal/files/2022-04/guidance-extensions-of-doctoral-studentships-due-to-the-covid-19-pandemic.pdf - 2026-07-04

Over the past couple of decades, increased interdependencies between and institutional defragmentation of, our Critical Infrastructures (CIs) have created a setting were traditional risk management might no longer suffice. In particular, analysis and management of risks have evolved from being a predominantly intra-organisational task towards a process that also requires inter-organisational coord

The main research question that guides the analysis for this Work Package 6 Deliverable 6.3 report is: What are the barriers and opportunities that govern niche development and scaling of aqua thermal energy (AE)systems? In answering this research question, we map and analyze the enabling policy and opportunitiesthat support AE system niche development, as well as policy that can also play a role

Northern forest ecosystems make up an important part of the global carbon cycle. Hence, monitoring local-scale gross primary production (GPP) of northern forest is essential for understanding climatic change impacts on terrestrial carbon sequestration and for assessing and planning management practices. Here we evaluate and compare four methods for estimating GPP using Sentinel-2 data in order to

Background Direct cell reprogramming is characterized by the use of defined factors to rewire the transcriptional and epigenetic network of one cell-type into one of a different lineage. We have recently identified the transcription factors PU.1, IRF8, and BAFT3 (PIB) as sufficient to induce a type 1 conventional dendritic cell (cDC1) fate in both somatic and cancer cells.1,2 cDC1 is a rare dendri

Propolis is a resin-like material produced by bees from the buds of poplar and cone-bearing trees and is used in beehive construction. Propolis is a common additive in various biocosmetics and health-related products, despite the fact that it is a well-known cause of contact allergy. Caffeic acid and its esters have been the primary suspects behind the sensitization potency of propolis-induced con

BACKGROUND: Lumbar puncture is a common invasive procedure performed in newborns for diagnostic and therapeutic purposes. Approximately one in two lumbar punctures fail, resulting in both short- and long-term negative consequences for the clinical management of patients. The most common positions used to perform lumbar puncture are the lateral decubitus and sitting position, and each can impact th

Water stress can severely decrease crop productivity by restricting photosynthesis, while the use of plastic film mulching can mitigate these water stress effects. However, the intricacies of photosynthetic and stomatal responses to soil water stress under plastic film mulching, particularly when combined with atmospheric water stress, have not been well studied, especially in arid irrigation area