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Background. To characterize participant reasons for withdrawing from a diabetes focused longitudinal clinical observational trial (TEDDY) during the first three study years. Methods. 8677 children were recruited into the TEDDY study. At participant withdrawal staff recorded any reason parents provided for withdrawal. Reasons were categorized into (1) family characteristics and (2) protocol reasons
POU5F1 has two alternatively spliced transcripts: a long (variant 1, NM_002701) and a short (variant 2, NM_203289) transcript. Only variant 1 is a key regulator of pluripotency. Hence, it is important to be able to distinguish this transcript from variant 2 and from the many pseudogenes present in the genome. Previous studies on the expression of POU5F1 were, however, usually carried out without c
Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoprotei
The Variation Ontology (VariO) is used for describing and annotating types, effects, consequences and mechanisms of variations. To facilitate easy and consistent annotations, the online application VariOtator was developed. For variation type annotations VariOtator is fully automated, accepting variant descriptions in Human Genome Variation Society (HGVS) format, and generating VariO terms, either
Although the direction of loads applied to the proximal human femur is unpredictable during sideways fall, most in vitro and numerical simulations refer to a single loading condition (15° internal rotation; 10° adduction), which has been anecdotally suggested in the 1950s. The aim of the present study was to improve in vitro simulations of sideways falls on the proximal femur. An in vitro setup w
The city of Stockholm has increased its number of surveillance cameras in public places the last few years in the name of crime prevention. However, as the number of cameras increases, how does this affect the people living in the city? This paper examines how surveillance cameras affect young women between the ages of 18-24 and their perception in different area around Sergels torg, T-Centralen a
I den här rapporten undersöks möjligheten för att tillverka och använda gjutmodeller tillverkade genom additiv tillverkning, i folkmun kallat 3D-printing. Först görs en grundläggande analys över hur modellerna tillverkas idag och vilka krav som ställs på modellen. Detta innefattar både rena material och hållfasthetskrav, men även mer svårdefinierade krav där man enbart kan resonera kring rimliga aIn this report the possibility for the manufacture and use of molding-patterns made through additive manufacturing methods, commonly called 3D-printing, is evaluated. First an analysis of how the patterns are currently being made and which demands that are put on them will be made. This includes more pure material and load demands, as well as more abstract and hard defined demands. After this the
Education has the potential to play a critical role in the sustainable transformation of society which is needed to limit the consequences of the multiple ecological crises society is facing. While this has been recognised internationally at least since 1992, not a lot has been done within the Danish educational system to address issues of climate change, biodiversity loss, and sustainability with
This case study investigates the involvement of private military companies (PMCs) in two African conflicts. Nigeria and Mozambique hired PMCs in 2014 and 2019 respectively to combat internal insurgencies. The paper aims to answer why these countries hired PMCs and if the PMCs were successful in combating the insurgencies. For the first question, the intensity of the insurgency and the state of the
The pressing issue of sustainability necessitates a broader collaboration span across all fields, such as finance and communication. Investments hold substantial power in the current sustainability reform, and it is therefore crucial that they not only meet the escalating demands of society but also actively contribute to forging a better future. The financial industry continues to grapple with ne
Investor sentiment is an important research object in behavioral finance, and its analysis has been one of the hot topics in stock market research recently. As an abstract concept, investor sentiment needs to be visualized by the construction of the investor sentiment index. In 2006, Baker and Wurgler proposed the Baker & Wurgler (BW) index, which can reflect investor sentiment in the American
Dark matter accounts for about 85% of all matter in the Universe, yet its particle nature remains unknown. The Light Dark Matter eXperiment (LDMX) is a proposed fixed-target missing-momentum experiment that intends to probe the predominantly experimentally uncharted MeV-GeV mass range for "light dark matter". A significant challenge for LDMX is to efficiently veto rare photo-nuclear back
Geographic Information Systems (GIS) are a powerful tool for supporting disaster risk reduction (DRR). International agreements such as the Sendai Framework for Disaster Risk Reduction call on high-income countries and other partners to support lower-income countries in strengthening their DRR capacities. This thesis explores the experiences of stakeholders in strengthening GIS capacities for DRR
Title: Food for Thought: Investigating Brand Activism and the Positioning of FMCG Brands in the Plant-Based Space Seminar date: 2022-06-03 Course: BUSN39, Degree Project in Global Marketing - Master Level Authors: Jesper Karlsson & Sophie Weir Advisor: Javier Cenamor Keywords: Brand activism, brand positioning, plant-based brands, FMCG, brand identity Research questions: How do marketing profe
Syftet med den här uppsatsen är att urskilja ett federalistiskt mönster inom EU:s makroekonomiska styrning och att söka förklaringar till förstärkningen av det rättsliga ramverket i detta avseende. Uppsatsen verkar i ett konstitutionellt perspektiv och antar ett multidimensionellt tillvägagångssätt för att uppfylla uppsatsens syfte. Gemensamt för dessa tillvägagångssätt är att de förhåller sig tilThe purpose of the thesis is to discern the pattern of federalism in EU macroeconomic governance and seek explanations for the strengthening of the framework in this regard. The thesis operates in a constitutional perspective, adopting a multidimensional approach in order to fulfil the purpose. These approaches have in common that they regard issues of legal power. By tackling the research questio
It is a common practise to quote option prices using their BlackScholes implied volatility. A volatility surface describes an options implied volatility as a function of the strike price and time to maturity. It can be used as a tool for hedging but also valuation when prices are not directly observable. The short-term evolution of this surface has been described by a variety of apocryphal rules.
Problem definition Additive manufacturing is a technology that has received a lot of attention and many are wondering how it will affect them plastic industry in the future. Additive manufacturing is mostly used for prototyping today but there is reason to believe that the technology has potential to overtake other application areas for plastic or used as a complementary method to existing manufac
This thesis work is part of a larger project with final goal to be able to measure the oxygen concentration in the lungs of infants, using non-invasive laser spectroscopy. This thesis is specifically dealing with simulations of light transport through the upper body of infants, as well as constructing a tissue-like model (phantom) that can be used in experiments. The goal is to use these simulatio
Nanowires are promising structures for improving light absorption due to their enhanced optical properties compared to bulk materials. Silicon is a suitable semiconducting material for driving water splitting in a photoelectrochemical (PEC) cell, and is particularly attractive due to its small bandgap as well as its relative abundance and low cost. PEC cells can be enhanced by including silicon na
