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BackgroundHypoplastic left heart syndrome is associated with significant morbidity and mortality. We aimed to assess the influence of left ventricular morphology and choice of shunt on adverse outcome in patients with hypoplastic left heart syndrome and stage 1 palliation.Methods and ResultsThis was a retrospective analysis of patients with hypoplastic left heart syndrome with stage 1 palliation b

BACKGROUND: Accumulating studies reported that several phosphodiesterases (PDEs) inhibitors might have cardiovascular benefits.OBJECTIVES: This study aimed to explore the relationship between genetically-predicted PDEs and ischemia heart disease via drug target Mendelian randomization (MR) approach, and then examine the effect of inhibitors of identified target on the outcomes by using real-world

PURPOSE: Several studies have indicated that broad genomic characterization of childhood cancer provides diagnostically and/or therapeutically relevant information in selected high-risk cases. However, the extent to which such characterization offers clinically actionable data in a prospective broadly inclusive setting remains largely unexplored.METHODS: We implemented prospective whole-genome seq

Background and purpose: Tamoxifen remains an important adjuvant treatment in premenopausal patients with hormone receptor-positive breast cancer. Thus, determination of hormone receptors is important. Here, we compare cytosol-based methods, immunohistochemistry (IHC), and gene expression (GEX) analysis for determining hormone receptor status in premenopausal breast cancer patients from a randomise

The effect of future changes in temperature and precipitation patterns on arctic ecosystem functioning is often assessed using state-of-the-art ecosystem models. Many models however lack detailed representation of wintertime processes, as pointed out by recent studies (Wang et al. 2016, Slater and Lawrence 2013). This bias may influence the derived outputs, such as soil temperature, permafrost ext

Title: The Power to be Creative - Unveiling the Influence of Power on Creativity Within Open Innovation Environments Authors: Savana Alves Pires and Arianna Isabelle Ragonese Purpose: This thesis aimed to explore the impact of power on creativity within an open innovation environment. Methodology: We employed a qualitative study utilizing the interpretivist tradition while using an abductive a

Gambling problems often coexist with various psychopathological conditions. The Hierarchical Taxonomy of Psychopathology (HiTOP; Kotov et al., 2017) offers an empirically based model to structure psychopathological symptoms into broader dimensional spectra, including internalizing (anxious-depressive), externalizing (impulsive-aggressive), and thought disorder (dissociated-psychotic) symptoms. The

Title: The Role of Concept Stores: Consumer Perceptions of the Intended Brand Image Seminar date: 2024-05-30 Course: BUSN39, Degree Project in Global Marketing, Business Administration: Master Level Authors: Petra Ohlson & Emma Stenkil Supervisor: Ulf Johansson Research question: Why are fashion manufacturing brands opening concept stores? How does consumers' perception of the concept stor

This thesis presents a comparative legal analysis of the dispute settlement mechanisms embedded in the EU–UK Withdrawal Agreement (WA), the Trade and Cooperation Agreement (TCA), and the framework of the World Trade Organization (WTO). In the aftermath of Brexit, the legal reconfigura-tion between the European Union and the United Kingdom has introduced new institutional and procedural complexitie

This thesis examines the norms, boundaries, and perceptions surrounding homosexuality in Swedish gay press between 1969 and 1973. The aim is to analyse how normative systems influenced the formation of identity, self-image, and sense of community among homosexual individuals. The aim is also to analyse how heteronormativity and the transgression of norms affected their relationship with society an

This essay deals with the tantric sect Aghora; its belief system, ritual practices and similarities with the Kapalika sect. Aghora exhibits peculiar and controversial ritual practices; for example the shava sadhana during which the aghori meditates on top of a corpse and then consumes part of it in order to reach identification with the god Shiva or the state of non-discrimination called aghor. Th

Purpose: The purpose of this study is to comprehend female millennial consumers’ perceptions towards lingerie brands that are categorised as ‘Brand Activist Aspirants’ compared to ‘Authentic Brand Activists’. Methodology: As this research focuses on studying consumers’ perceptions, a subjective social constructionist view was taken. By using an abductive approach, an exploratory qualitative resear

Lunds Klimatallians har ambitioner att hjälpa sina medlemmar arbeta mot en hållbar utveckling och letar efter nya metoder för att förbättra sin insats. Lunds Klimatallians är en organisation som startades i initiativ av Lund Kommuns miljöstrategiska enhet i syfte att bidra till Sveriges genomförande av FN:s klimatmål. Målen ska leda världen mot en hållbar utveckling men i dagsläget finns hållbarheLund's Climate Alliance was initiated 2010 by the municipality of Lund, in southern Sweden, to support local climate adaptation and mitigation efforts. The purpose of this paper is to investigate what each member of Lund's Climate Alliance believes will be necessary to realize sustainability goals particular to their organization in the future. The study thereby points to new topics, activ

Arsenic is a very potent toxicant. One major susceptibility factor for arsenic-related toxicity is the efficiency of arsenic metabolism. The efficiency, in turn, is associated with non-coding single nucleotide polymorphisms (SNPs) in the arsenic methyltransferase AS3MT on chromosome 10q24. However, the mechanism of action for these SNPs is not yet clarified. Here, we assessed the influence of gene

Background: Selective dorsal rhizotomy (SDR) is a well accepted neurosurgical procedure performed for the relief of spasticity interfering with motor function in children with spastic cerebral palsy (CP). The goal is to improve function, but long-term outcome studies are rare. The aims of this study were to evaluate long-term functional outcomes, safety and side effects during five postoperative y

Background: Subjects with non-O ABO blood group alleles have increased risk of pancreatic cancer. Glycosyltransferase activity is greater for the A(1) versus A(2) variant, whereas O01 and O02 variants are nonfunctioning. We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotyp

Background: The health status of individuals is determined by multiple factors operating at both micro and macro levels and the interactive effects of them. Measures of health inequalities should reflect such determinants explicitly through sources of levels and combining mean differences at group levels and the variation of individuals, for the benefits of decision making and intervention plannin