Search results

Popular Abstract in Swedish Diabetes är en världssjukdom – om 50 år räknar det internationella diabetesförbundet med att en tiondel av världens befolkning har någon form av diabetes. Diabetes innebär att kroppen inte kan ta hand om allt socker som man äter. Detta medför att sockerhalten i blodet blir för högt. Högt blodsocker gör att kroppens celler arbetar konstant, och om blodsockret är för högtThe primary aim of this thesis was to investigate the role of G protein coupled receptors (GPCRs) in insulin secretion and beta-cell survival. The second aim was to determine which pathway is involved in insulin release and beta-cell protection via GPCRs. This has been investigated in three different studies, which concluded the following: Study 1) GPR30 is expressed in female mice pancreatic isle

An overview of the present knowledge about succinate:quinone oxidoreductase in Paracoccus denitrificans and Bacillus subtilis is presented. P. denitrificans contains a monoheme succinate:ubiquinone oxidoreductase that is similar to that of mammalian mitochondria with respect to composition and sensitivity to carboxin. Results obtained with carboxin-resistant P. denitrificans mutants provide inform

In communication systems, all service control nodes, such as for example Web sites or mobile switching centers, can be modeled as a server system with one or more servers processing the incoming requests. To avoid overload at the service node some type of admission control mechanism is usually implemented to guarantee good performance also during high traffic loads. In this paper we investigate, f

Prostate specific antigen (PSA) is a well-established tumor marker, which is frequently employed as model biomarker to develop and evaluate emerging quantitative proteomics techniques, partially due to wide access to commercialized immunoassays serving as "gold standard". We designed a multiple reaction monitoring (MRM) assay to detect PSA proteoforms in clinical samples (n=72), utilizing specific

Shannon's seminal approach to estimating information capacity is widely used to quantify information processing by biological systems. However, the Shannon information theory, which is based on power spectrum estimation, necessarily contains two sources of error: time delay bias error and random error. These errors are particularly important for systems with relatively large time delay values and

The Biochemical Methane Potential (BMP) test is increasingly recognised as a tool for selecting and pricing biomass material for production of biogas. However, the results for the same substrate often differ between laboratories and much work to standardise such tests is still needed. In the current study, the effects from four environmental factors (i.e. ambient temperature and pressure, water va

We demonstrate the reversible intercalation of CO between a hexagonal boron nitride (h-BN) monolayer and a Rh(111) substrate above a threshold CO pressure of 0.01 mbar at room temperature. The intercalation of CO results in the flattening of the originally corrugated h-BN nanomesh and an electronic decoupling of the BN layer from the Rh substrate. The intercalated CO molecules assume a coverage an

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To determine whether rare or low-frequency coding variants are associated with LDL-C, we exome sequenc

The article analyzes the recent genre of Islamic children’s picture books, originally produced as a means of religious socialization for the British Muslim communities, but marked on a global Islamic market. Particular attention is devoted to the visual norms of the books produced by one of the pioneering publishers of Islamic children’s literature, the Islamic Foundation. With one foot in the ped

Avhandlingen, som består av fyra delstudier, är en femårsuppföljning av kvinnliga missbrukare, som var tvångsomhändertagna på Lunden mellan januari 1997 och december 2000, och som genomgick en omfattande utredning. Klienterna har systematiskt utretts med psykologiska och neuropsykologiska test i samarbete med personal och Lundens psykiater. Test och skattningsskalor som använts är standardiserade The study focus is a sample of women with drug dependence admitted to compulsory treatment according to the Swedish act of care for drug abusers (LVM, 1988:870) and according to the act of care for young persons (LVU, 1990:52). From a cohort consecutively admitted to residential treatment at Lunden between 1997 and 2000, a sample of 132 women was selected for a five year follow-up. They were evalu

BACKGROUND: Knee rotation plays an important part in knee kinematics during weight-bearing activities. An external device for measuring knee rotation (the Rottometer) has previously been evaluated for validity by simultaneous measurements of skeletal movements with Roentgen Stereometric Analysis (RSA). The aim of this study was to investigate the reliability of the device. METHOD: The within-day

The validity of a Swedish translation of the Measures of Criminal Attitudes and Associates (MCAA) was evaluated. All four subscales showed acceptable reliability, but the Entitlement scale can be improved by replacing items with low loadings. Confirmatory factor analysis supported a model with one common criminal attitude factor and three subfactors (corresponding to subscales of the test). The An

Previous research has shown a male bias in the media. This study tests this statement by examining how the pronouns She and He are used in a news media context. More specifically, the study tests whether He occurs more often and in more positive semantic contexts than She, as well as whether She is associated with more stereotypically and essential labels than He is. Latent semantic analysis (LSA)

The release of two compositionally different solutes from a composite gel composed of two different populations of microgel particles embedded in a single bulk gel matrix is described, showing the potential of the "plum-pudding gel" as a multifunctional platform for controlled surface release. One hydrophobic solute (pyrene) and one hydrophobic and charged solute (rhodamine 123) were chosen as the

The need to estimate indoor temperatures, heating or cooling load and energy requirements for buildings arises in many stages of a buildings life cycle, e.g. at the early layout stage, during the design of a building and for energy retrofitting planning. Other purposes are to meat the authorities requirements given in building codes. All these situations require good calculation methods. The main

The capacity of downlink cellular multiple-input multiple-output (MIMO) systems, where co-channel interference is the dominant. channel impairment, is investigated in this paper, mainly from a signal-processing perspective. Turbo space-time multiuser detection (ST MUD) is employed for intracell communications and is shown to closely approach the ultimate capacity limits in Gaussian ambient noise f

We present detailed low-temperature transport measurements of a single quantum dot formed in an InGaAs/InP heterostructure with a strong tunnel coupling to the source and drain leads. The conventional spin-1/2 Kondo effect is observed for the quantum dot in the N = 9 charge state. By changing the voltages applied to the quantum dot barrier gates, we find a zero-field splitting of the Kondo resonan

The response of electric devices to an applied thermal gradient has, so far, been studied almost exclusively in two-terminal devices. Here we present measurements of the response to a thermal bias of a four-terminal, quasiballistic junction with a central scattering site. We find a novel transverse thermovoltage measured across isothermal contacts. Using a multiterminal scattering model extended t

The European steady-state Simple Mass Balance (SMB) model and the dynamic soil acidification model SAFE were used to assess the risk of future forest soil acidification in Switzerland. 2010 deposition forecasts on a 150x150 km grid resolution as well as corresponding ecosystem protection levels were obtained from RAINS model runs based on the 1999 Gothenburg Protocol obligations under the UN/ECE L

The biochemistry and molecular genetics underlying the related carbohydrate blood group antigens P, P(k), and LKE in the GLOB collection and P1 in the P blood group system are complex and not fully understood. Individuals with the rare but clinically important erythrocyte phenotypes P(1)k and P(2)k lack the capability to synthesize P antigen identified as globoside, the cellular receptor for Parvo