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Prediction of Allosteric Binding Modes in Homologous NMDA-Receptors

The NMDA receptors are natural glutamate binders that play critical roles in the function of the central nervous system, with their dysfunction implicated in serious psychiatric disorders and neurodegenerative conditions. Understanding their roles in the brain and developing treatments will benefit from the existence of small molecules specifically targeting different NMDA receptor subtypes. This

Har HD kastat ut barnet med badvattnet? - Konsekvensanalys av NJA 2022 s. 1115 ”Lägenheten på Sibyllegatan”

På senare tid har en särskild typ av företag, vars affärsverksamhet går ut på att hyra bostadslägenheter för att vidareupplåta dem till företag som behöver personalbostäder, vuxit fram på hyresmarknaden i Sverige. Detta fenomen är vanligast i storstadsregionerna, företagen brukar kallas för mellanhandsföretag och bostäderna som hyrs ut för företagsbostäder. En av reglerna som aktualiseras vid dennIn recent years, a new category of business has emerged within the Swedish rental housing market, operating by leasing residential flats and subsequently subletting them to companies in need of staff accommodation. This phenomenon is most prevalent in metropolitan areas. Such businesses are usually referred to as intermediary companies, and the flats as corporate apartments. One of the legal provi

Begränsandet av billighetsskälen och upprättelse för brottsoffer

I juli 2023 tillsatte regeringen en utredning i syfte att genomföra en övergri- pande översyn av straffskalorna samt lägga fram förslag till ett reformerat och mer rättvist påföljdssystem. Regeringen framhåller i direktivet att straffsyste- met bör uttrycka en tydligare klandervärdering av brottsliga gärningar för att undvika att brottsoffer upplever rättsprocessen som ytterligare en kränkning. DeIn July 2023, the Swedish government appointed an inquiry with the purpose of conducting a comprehensive review of the penalty scales and presenting proposals for a reformed and fairer penalty system. The government empha- sizes in the directive that the penal system should express a clearer condem- nation of the blameworthiness of criminal acts in order to avoid that victims experience the legal

Kärnegenskap som anses utfäst – En undersökning av säljarens skadeståndsansvar vid avsaknad av kärnegenskap

Vid fel i köpt egendom har köparen möjlighet att rikta skadeståndsanspråk mot säljaren. Beroende på om den köpta egendomen är fast eller lös egendom skiljer sig skadeståndsgrunderna åt. En gemensam skadeståndsgrund är säljarens ansvar för utfästelser, som fastställer att säljaren blir skadeståndsskyldig om egendomen avviker från vad säljaren har utfäst. Vid fel i fast egendom har HD har genom NJA In case of defects in purchased property, the buyer has the possibility to claim damages for the loss. Depending on whether the purchased property is real or personal property, the grounds for damages differ. A common ground for damages is the seller’s liability for representations, which establishes that the seller is liable for damages if the property differs from what the seller has represented

Made in EU-China - How the EU's role conception and expectation of its external action is shaped by China

The relationship between the European Union (EU) and China distinguishes itself by its unique nature and place in world affairs. The two distinctive economic giants have over the past two decades developed a structured relationship centred around trade and major economic interests. Growing in both intensity and complexity, EU-China engagements have over the years produced evidence to suggest for t

Själ att döma - En komparativ studie av juridiska personers straffrättsliga ansvar

Den här uppsatsen undersöker juridiska personers roll som straffrättsliga förövare. Undersökningen har genomförts i ett antal delar. Den börjar generellt och blir mer specifik under uppsatsens gång. För att kunna undersöka hur straffrätten och juridiska personer interagerar med varandra etableras först straffrättens vedergällande och utilitaristiska syften och funktioner. Hur dessa interagerar medThis thesis examines criminal liability for legal persons. The examination has been done in several parts. It starts generally and becomes more specific over the course of the thesis. In order to examine how criminal law and legal persons interact with each other the thesis starts by establishing the retributive and utilitarian purposes and functions of criminal law. The interactions between retri

The pollination tragedy

The creation of floral resources for pollinators, such as flower strips, is seen as a relevant and needed intervention but comes with both cost and an opportunity for farmers. It may be worth it if, for example, pollinators are attracted to pollinator-dependent crops and deliver crop pollination. Unfortunately, since pollinators are mobile organisms, the spatial distribution of crop pollination re

Undersökning av Workflow Core och Elasticsearch för förbättrad hantering av arbetsflöden

Under den senaste tiden har det skett en betydande ökning av intresse inom forskningen och utvecklingen av arbetsflödesmotorer som är tekniska verktyg för att styra en sekvens av steg och processer. Detta har bidragit till bättre automatisering av komplexa och tidskrävande arbetsprocesser. I en del av de verksamhetssystem som Advania levererar finns det ofta ett behov av att kunna sätta upp och koIn recent times, there has been a significant increase in interest regarding the research and development of workflow engines, which are technical tools to control a sequence of steps and processes. This has enhanced the automation process of complex and time-consuming work processes. In some of the operational systems that Advania delivers, there is often a need to set up and configure different

Det digitala guldet - en juridisk gråzon? En analys huruvida Bitcoin går att utmäta i ljuset av utsökningsbalken.

Teknisk innovation inom den finansiella sektorn och inom elektronisk han- del har växt dom senaste åren. Detta har bidragit till att nuvarande betal- ningsmarknad erbjuder allt fler digitala betalmetoder för enskilda- och juri- diska personer. En utav dessa betalmetoder är Bitcoin. Bitcoin fick sitt ge- nomslag efter finanskrisen 2009 och har sedan dess lockat användare värl- den över. Bitcoin är Technical innovation within the financial sector and electronic commerce has grown in recent years. This has contributed to the current payment mar- ket offering an increasing number of digital payment methods for individu- als and legal entities. One of these payment methods is Bitcoin. Bitcoin gai- ned prominence after the 2009 financial crisis and has since attracted users worldwide. Bitcoin is

Detaljplan eller Vägplan? - En jämförelse mellan plan- och bygglagen och väglagen som medel i kommunal infrastrukturplanering

Det svenska vägnätet är uppdelat i allmänna vägar, kommunala gator och enskilda vägar. De allmänna vägarna sköts generellt av staten via Trafikverket. Ansvaret kan emellertid, om regeringen lämnat ett förordnande om det, överlämnas till den berörda kommunen. Förordnandet kan gälla för ett helt område, eller enskilda vägar. Kommunen är väghållare för de kommunala gatorna inom detaljplan med kommunaA municipality in Sweden has two different choices regarding how to plan and build transportational infrastructure such as roads. The most used way is to use the planning and building act and establish a detailed development plan, but the municipality could also establish a road plan according to the road act. This paper examines the connection between the two laws and how those apply on the munic

Digitala folkminnen : en uppsats om enskild internetarkivering

This thesis examines the preservation of social media user activity as digitala folkminnen (digital folk memories), using as a case the two Swedish platforms of LunarStorm and Bilddagboken (Dayviews), which were integral to the daily lives of young people in Sweden in the early 2000s. As these platforms face closure or data loss, there is a risk of losing users’ contributions forever. While govern

Sexköpslagen i Sverige respektive Finland: En komparativ studie ur ett moralfilosofiskt perspektiv

Uppsatsen behandlar hur köp av sexuella tjänster regleras i Norden, med ett särskilt fokus på komparationen av den svenska respektive finska lagstiftningen ur ett moralfilosofiskt perspektiv. Den svenska lagstiftningens bestämmelse återfinns i 6 kap. 11 § brottsbalken (BrB), vilken konstaterar att den som skaffar sig en tillfällig sexuell förbindelse mot ersättning som döms för köp av sexuell tjänThe essay discusses the regulation of the purchase of sexual services in the Nordic countries, with a particular focus on the comparison of Swedish legislation which is found in Chapter 6, paragraph 11 of the Swedish Penal Code (BrB), stating that anyone who engages in a temporary sexual connection for compensation is sentenced to a maximum of one year in prison for the purchase of sexual services

Ungdomsfängelse - symbol för en offensiv kriminalpolitik? En diskursanalys av de kriminalpolitiska trenderna med utredningen om ungdomsfängelser som exempel

I november 2021 beslutade den dåvarande regeringen att tillsätta en utredning för att göra en översyn av regleringen om frihetsberövande påföljder för unga. I augusti 2023 publicerades utredningen som ställer sig positiv införandet av s.k. ungdomsfängelser. Den frihetsberövande påföljd som i nuläget finns för unga lagöverträdare (15–17 år), utöver fängelse, är sluten ungdomsvård (och stadgas i 32 In November 2021, the Swedish government at the time decided to appoint an inquiry to review the regulations on custodial sanctions for young people. In August 2023, the investigation was published, which is in favor of juvenile prisons. The custodial sanction that currently exists for young offenders (15-17 years old), in addition to imprisonment, is "closed youth care" (and is stipulat

Synonymous codon selection bias and its impact on evolutionary co-translational protein folding

Protein biosynthesis follows a hierarchical process, as genes are transcribed into mRNA, translated into a chain of amino acids, and ultimately folded into functional proteins. This implies that the protein structure is merely determined by the amino acid sequence. Yet, studies on translation efficiency indicate that codon usage, which is organism dependent, significantly impacts protein folding k

Den stigmatiserade mannen - En kvalitativ studie om några mäns erfarenheter av att vara våldsutsatt av en kvinna i nära relation

The purpose of this study was to investigate men's experiences of being subjected to domestic violence by their female partners, identify the consequences of this violence, and analyse barriers to seeking help or leaving the relationship. The goal is to understand the nature of the violence and its impact on the men involved. Two theories have been used to analyse the results: Goffman’s theory

Ådalen - Craft in Continuation

The site of the project is located in Ådalen, a stretch along Ångermanälven in northern Sweden. A region that during the 19th century grew and flourished through the wood industry only to stagnate and be phased out in the middle of the 20th century. After that the region has been fraught with closures and population decline. In relation to the industries that have existed in the region, I have c

Environmental protests- Should I stay or should I go? Reasons for not going

Abstract Devastating climate change, polluted oceans and biodiversity loss make up only a few of the issues facing the planet in the current man made environmental crisis. Many efforts have been made, but often failed in an attempt to mitigate the crisis. Many social scientists suggest that environmental movements have the potential of promoting change. In Spite of the impressive size of recent en

Pretreatment of lignocellulosic biomass at atmospheric conditions by using different organosolv liquors: a comparison of lignin

In order to strengthen the bio-based economy, it is necessary to produce value-added products by processing all fractions of the biomass, especially lignin. Isolation of lignin at atmospheric pressure and lower temperature will make it possible to recover lignin and use it for different purposes. In the present study, lignins were recovered from wood sawdust by applying six different organosolv tr

Identification, isolation and analysis of human gut-associated lymphoid tissues

Gut-associated lymphoid tissues (GALTs) comprise key intestinal immune inductive sites, including the Peyer’s patches of the small intestine and different types of isolated lymphoid follicle (ILF) found along the length of the gut. Our understanding of human GALT is limited due to a lack of protocols for their isolation. Here we describe a technique that, uniquely among intestinal cell isolation p

Serotonin transporter messenger RNA expression in neural crest-derived structures and sensory pathways of the developing rat embryo

A growing body of evidence suggests that serotonin plays an important role in the early development of both neural and non-neural tissues from vertebrate and invertebrate species. Serotonin is removed from the extracellular space by the cocaine- and antidepressant-sensitive serotonin transporter, thereby limiting its action on receptors. In situ hybridization histochemistry was used to delineate s