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Aim: The increasing spread of vector-borne diseases has resulted in severe health concerns for humans, domestic animals and wildlife, with changes in land use and the introduction of invasive species being among the main possible causes for this increase. We explored several ecological drivers potentially affecting the local prevalence and richness of avian malaria parasite lineages in native and

Background: Deep learning (DL)-based organ segmentation is increasingly used in radiotherapy. While methods exist to generate voxel-wise uncertainty maps from DL-based auto-segmentation models, these maps are rarely presented to clinicians. Purpose: This study aimed to evaluate the impact of DL-generated uncertainty maps on experienced radiation oncologists during the manual correction of DL-based

Aim: Clinical trial data have demonstrated that direct oral anticoagulants (DOACs) are both noninferior to and safer than conventional therapy for the treatment of venous thromboembolism (VTE). This study aimed to compare the effectiveness and safety of DOACs versus warfarin using Nordic population-based registries. Materials & methods: This observational cohort study used Swedish, Norwegian a

Research on HIV vaccines, as well as studies on HIV pathogenesis in human and SIV in the macaque model, require the availability of simple and standardized assays for quantification of neutralizing antibodies to primary virus isolates. We have recently developed and standardized assays using human cell lines engineered to express CD4 and co-receptors for HIV and SIV entry. One cell line originated

Aims: To evaluate the effects of adding glucagon-like peptide-1 (GLP-1) analogue therapy to insulin on glycated hemoglobin (HbA1c), weight, insulin dosage, treatment satisfaction, and risk of hypoglycaemia. Methods: Type 2 diabetes patients with insulin therapy receiving a GLP-1 analogue at 4 Swedish centers were studied. Hypoglycemia was evaluated using glucometers and patient self-report. The Di

BackgroundHeart failure is an established risk factor for poor outcomes in patients undergoing non-cardiac surgery, yet risk stratification remains a clinical challenge. We developed an index for 30-day mortality risk prediction in this particular group. Methods and resultsAll individuals with heart failure undergoing non-cardiac surgery between October 23 2004 and October 31 2011 were included fr

An increase in hip fracture incidence during the recent half-century has been reported worldwide and has been predicted to continue. Recent publications, however, have reported stable or even decreasing hip fracture incidence. No reports evaluate whether these changes in hip fracture incidence are associated with changes in bone mineral density (BMD), if they apply in both urban and rural settings

Objective. New proposed definitions of chronic kidney disease necessitate the development and use of simple and accurate methods for estimating glomerular filtration rate (GFR). Plasma cystatin C has been shown to be a more reliable GFR marker than creatinine and formulae for estimating GFR have been reported. The purpose of this study was to validate a cystatin C-based GFR prediction equation in

It is important to understand the relative contribution of primary and secondary particles to regional and global aerosol so that models can attribute aerosol radiative forcing to different sources. In large-scale models, there is considerable uncertainty associated with treatments of particle formation (nucleation) in the boundary layer (BL) and in the size distribution of emitted primary particl

Post-translational modifications of proteins can generate antigenic conformations that may cause autoimmune diseases in persons with specific HLA-haplotypes. Monocytes and macrophages, attracted to an inflamed site, can release post-translationally acting enzymes, such as transglutaminases and peptidylarginine deiminases. In vivo, the activation of these enzymes is crucial for the further course o

The VDR is a prime candidate gene for osteoporosis. Here, we studied three common VDR haplotypes in relation to bone phenotypes in 5014 participants of the global MrOS Study. We also studied the relative expression of the haplotypes in human bone cells. One haplotype was associated with increased fracture risk and differently expressed in primary human bone cells. Introduction: Vitamin D plays an

Det finns en stor potential för ett ökat utnyttjande av biomassa för energiändamål i Sverige. En ökad användning av biomassa skulle kunna bidra till att minska utsläppen av koldioxid från förbränning av fossila bränslen, minska beroendet av importerade fossila energibärare samt påverka den regionala och lokala miljösituationen såväl positivt som negativt. Föreliggande studie behandlar framför alltThere is a large potential for increasing the use of biomass for energy purposes in Sweden. Increasing the use of biomass can reduce emissions of carbon dioxide (CO2) from fossil-fuel combustion and dependence on imported fossil fuels. Furthermore, increased biomass use will affect emissions of other air pollutants than carbon dioxide as well as environmental impacts from land use. The study deals

Background: Obesity and its associated metabolic complications continue to increase worldwide. We investigated the development of metabolic syndrome (MetS) during aging in relation to body mass index (BMI) and exercise habits. We assigned special emphasis to the metabolic stability in individuals with obesity, but without MetS, a condition often referred to as metabolically healthy obesity. Materi

During the course of this three-year project, we have studied aeolian deposits at 70 sites within sixteen areas in south-central Sweden. Inland dunes have been the focus, but some sites with coversand and coastal dunes have also been investigated. We have mapped dune morphology, mainly by LiDAR-based remote sensing, studied the internal sediment architecture by ground-penetrating radar profiling a

OBJECTIVE: The aim of this study was to describe the clinical characteristics of early onset prostate cancer, with special reference to family history as a possible prognostic factor.MATERIAL AND METHODS: We identified all cases of prostate cancer diagnosed before the age of 51 in the Southern health care region in Sweden between 1958 and 1994. Clinical data were collected retrospectively from med

Popular Abstract in Swedish Vad är det för något i human mjölk som dödar cancer celler? Kan “fel” veckade proteiner vara nyttiga? Kan fett vara inblandat i protein veckning? Det är några av frågorna som tas upp i denna avhandling. Allt levande består av proteiner som i sin tur är uppbyggda av amino syror. Det finns 20 st. olika amino syror som på olika sätt kan länkas samman till proteinkedjor. DBy varying its secondary or tertiary structure a single protein can attain new biological functions. The amyloid forming proteins are the best known examples where a change in conformation leads to the formation of amyloid fibrils that accumulate in tissues and cause disease. a-lactalbumin in contrast, is an example of a protein that acquires a beneficial function when the conformation is altered

Popular Abstract in Swedish Andelen vindkraft i elnätet har ständigt ökat under de senaste åren. I många länder utgör idag vindkraften en betydande del av den totala elproduktionen. Detta gäller även vid störningar då vindkraftverk – precis som vattenkraftverk och kärnkraftverk – måste fortsätta bidra till balansen mellan elproduktion och förbrukning. De nya reglerna för anslutning av vindkraft tiSynchronous generators have always been the dominant generation type in the grid. This fact affected both planning and operation of power systems. With the fast increase of wind power share in the grid in the last decade, the situation is changing. In some countries wind power represents already a consistent amount of the total generation. Wind turbines can be classified as non-synchronous generat

Title: Next generation rear axle assembly - A case study at Scania Authors: Richard Andrae & William Bergmark Background: Following the development of industry 4.0, new production technologies enabling more efficient assembly processes constantly evolve. Scania is a leading manufacturer of trucks in Sweden, offering a wide product portfolio and the possibility for their customers to customize

Att exploatera jordbruksmark är idag en debatterad fråga. Det tar många år för jordbruksmarken att utvecklas och marken är avgörande för Sveriges livsmedelsproduktion. Samtidigt som marken kring våra städer behövs för att bygga nya bostäder och verksamheter. Idag finns det ett skydd i 3 kap. 4 § miljöbalken (MB) för brukningsvärd jordbruksmark mot exploatering som inte är av väsentligt samhällsintExploitation of agricultural land is today a debated issue. It takes many years for agricultural land to develop and the land is important to preserve for food production. However, land in general is also needed for the development of new housing and new businesses. Today agriculture land is protected by Chapter 3, Section 4 of the Swedish Environmental Code. This section protects agricultural lan