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doi:10.1016/j.yexcr.2006.12.014 Research Article Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells Elin K.I. Anderssona,b, Dwain K. Irvina,c, Jessica Ahlsiöa, Malin Parmara,b,⁎ aWallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, S-221 84 Lund, Sweden bLund Strategic Center for Stem Cell Biology and
Syfte: Syftet med uppsatsen är att undersöka vilka kompetenser som anses viktiga för en revisor att besitta och utifrån Det dubbla greppet analysera hur den teknologiska utveckl-ingen i revisionsbranschen har påverkat revisorns kompetenser. Metod: För att undersöka syftet har en intressentanalys genomförts. Denna har genomfört med hjälp av kvalitativa och semi-strukturerade intervjuer med sex olPurpose: The purpose of this essay is to investigate which competences that’s considered important for auditors to possess and based on Det dubbla greppet analyse how the techno-logical development has effected competences auditors possess. Methodology: In order to investigate the purpose of the essay the authors conducted a stakeholder analysis. To achieve this semi structured qualitative inter
We present palaeomagnetic secular variation and relative palaeointensity estimates from multiple sediment cores recovered from a varved lake sediment sequence in Kalksjon, a lake in central west Sweden. Alternating field demagnetization of discrete samples reveals natural remanent magnetizations dominated by a stable, single component. Magnetic grain size indicators-which include Day plots and fir
Traits that increase mating success in males may come at a cost, such as an increased risk of predation. However, predator-mediated selection is challenging to document in natural populations, hampering our understanding of the trade-offs between sexual selection and predation. Here we report on a study of predator-mediated natural selection on wing traits in the damselfly Calopteryx splendens, th
Understanding the relationship between photosynthesis, net primary productivity and growth in forest ecosystems is key to understanding how these ecosystems will respond to global anthropogenic change, yet the linkages among these components are rarely explored in detail. We provide the first comprehensive description of the productivity, respiration and carbon allocation of contrasting lowland Am
In I-123-IBZM brainSPECT, the main interest is the activity uptake in the striatum relative to the background, and semi-quantitative techniques using regions of interest are typically used for this purpose. Uncertainties in the measured uptakes can however be a problem due to low contrasts and high noise levels. Like SPECT in general, IBZM SPECT should benefit from reconstruction methods that incl
The platelet-derived growth factor (PDGF) ß receptor mediates mitogenic and chemotactic signals. Like other tyrosine kinase receptors, the PDGF ß receptor is negatively regulated by protein tyrosine phosphatases (PTPs). To explore whether T-cell PTP (TC-PTP) negatively regulates the PDGF ß receptor, we compared PDGF ß receptor tyrosine phosphorylation in wild-type and TC-PTP knockout (ko) mouse em
Nucleic acid aptamer selection is a powerful strategy for the development of regulatory agents for molecular intervention. Accordingly, aptamers have proven their diligence in the intervention with serine protease activities, which play important roles in physiology and pathophysiology. Nonetheless, there are only a few studies on the molecular basis underlying aptamer-protease interactions and th
Popular Abstract in Swedish Fotosyntesen är den process i växter, alger och fotoautotrofa bakterier, där solljusets energi fångas i kemiska föreningar och levande materia. Avsikten med konstgjord fotosyntes är på lång sikt att framställa bränsle (t ex vätgas) med hjälp av solenergi och vatten, enligt fotosyntesens principer. I växter är den centrala principen för denna process, som är den viktigasPhotosynthesis is the process by which light energy is converted into chemical products, in photoautotrophic bacteria, algae and plants. The principal idea is the production of reducing agents by photo-induced oxidation of a sacrificial electron donor. Photosystem II in plants, algae and cyanobacteria, absorbs light and catalyzes the oxidation of water, liberating electrons that are used to form r
Popular Abstract in Swedish Benskörhet (osteoporos) är ett tillstånd som definieras av låg benmassa och ökar med stigande ålder. Osteoporos är idag en av de stora folksjukdomarna och man räknar med att en tiondel av alla män och en fjärdedel av alla kvinnor i Sverige drabbas. Tillståndet är i sig symptomfritt men ökar risken att råka ut för ett benbrott (fraktur) redan vid lättare fall. Frakturer The aim of this thesis was to evaluate risk factors for bone fragility and fractures in postmenopausal women in a long-term perspective. The study period spanned from the age of 48 to age 82 and is thus unique in its length. The studied sample was homogeneous and consisted of 390 north European women from a population-based cohort. At the start of the study, general health and lifestyle parameters
The Black-headed Gull Larus ridibundus is a monomorphic species with little size variation over its wide distribution range. This is in agreement with the wide dispersal of young birds and change of breeding sites of adults between years, which probably means an almost panmictic dispersal of genes. In 1965 I measured and weighed 319 eggs collected at Sjolunda near Malmo, southern Sweden. When I go
In order to evaluate three common human papillomavirus (HPV) DNA tests for key performance indices in population-based cervical screening, we sampled 12,527 women aged 3238 years who attended invitational, population-based screening and followed them for 4 years with comprehensive registry linkages. Three different HPV DNA tests (GP5+/6+general primer PCR (using either AmpliTaq or AmpliTaq Gold DN
Background Acute pyelonephritis is a common infection in adult women, but there is a paucity of controlled trials of its treatment and the optimum duration of antibiotic treatment has not been properly defined. We compared the efficacy of ciprofloxacin for 7 days and 14 days in women with community-acquired acute pyelonephritis. Methods In a prospective, non-inferiority trial undertaken at 21 cent
Soils beneath former dry cleaning sites are often contaminated with the chlorinated hydrocarbons PCE and its degradation products, which are highly toxic and cancerogenic. In this study, resistivity and time domain induced polarization (DCIP) were measured at a former dry cleaning site in order to investigate if the source contamination of PCE could be detected. 80 meter long 2D-profiles were meas
1. Task-dependent modulation of cutaneous input to climbing fibres projecting to the C1, C2 and C3 zones in the cerebellar paravermal lobule V was investigated in awake cats during performance of a reaching task. 2. Climbing fibre responses resulting from low intensity (non-noxious) electrical stimulation of the ipsilateral superficial radial nerve were recorded as extracellular field potentials i
