Filetype
From Strands to Wires All the genetic information required to develop and maintain an organism is packed tightly into the molecule known as DNA. Determining the order of the four bases, which are the building blocks of DNA, enables the identification of a DNA segment. Modern disease diagnostics use this identification method, known as DNA sequencing, to inspect genetic integrity. Thus, it is vita
BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy
Introduction Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugat
BACKGROUND: The ORBITA and ORBITA-2 trials have provided valuable insights into the effects of coronary revascularization in chronic coronary syndrome (CCS). However, uncertainties remain regarding the efficacy of revascularization on symptoms in large real-world populations. To evaluate the efficacy of revascularization, we used dispensed long-acting nitrates as a proxy for the presence of angina
This study aimed to test and validate a dual-time-window (DTW) protocol for 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]MK6240) dynamic PET imaging in experimental datasets acquired in human subjects. Methods: DTW protocols were tested and validated in datasets previously collected in 25 participants: 13 were cognitively normal, 10 had mild cognitive impairment, and 2
Context. Ultra-hot Jupiters present a unique opportunity to understand the physics and chemistry of planets, their atmospheres, and interiors at extreme conditions. WASP-12 b stands out as an archetype of this class of exoplanets, with a close-in orbit around its star that results in intense stellar irradiation and tidal effects. Aims. The goals are to measure the planet's tidal deformation, atmos
BackgroundChronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are characterized by persistent airway inflammation and airflow limitation. Measuring airway inflammation may be of value both in research and clinical practice. Calprotectin, a protein associated with neutrophil activation, serves as a potential biomarker for airway inflammation. This study evaluates the performance o
Cooperation in soils can make a huge difference At a first glance, the coexistence of diverse plants in ecosystems seems to be completely harmonious. However, there is a high competence of these organisms for obtaining resources. In this scenario, most of the plants have decided to make a lifetime deal with fungi in order to ensure their development and survival. This symbiotic association is cal
Controlling growth of a cell How incredible would it be to control growth of cells? One of the most basic mechanisms in life. This knowledge would be especially useful for treating threatening cells such as cancer cells or pathogenic bacteria. It would be lifesaving to understand and determine their growth. Here the focus is on growth of bacteria, particularly those belonging to the genus Strepto
An upcoming trend in the current IT-landscape is to outsource services to so called Cloud Service Providers (CSPs). However, many companies are still sceptical to this new kind of services, since they bring about a certain loss of control. For this reason, it is important for CSPs to show that their services are secure. There are several options in proving this and it is up to every CSP to choose
Sveriges regering satte 2011 upp mål om att bli bäst på att utnyttja digitaliseringens möjligheter. Digitaliseringen av bygglovsprocessen har trots det gått långsamt. Bygglovsprocessen idag (2018) är en långsam, dyr och ineffektiv process. Möjligheten att söka bygglov med e-legitimation finns endast hos 30 procent av kommunerna och 60 procent har någon slags e-tjänst ansökan. Ansökningarna innebärThe Swedish government set up a goal in 2011 of making the best use of digitization opportunities. The digitization of the building permit process has, however, been slow. The process of building permits is today (2018) a slow, expensive and inefficient process. The possibilities to apply for building permits with e-credentials is only available in 30 percent of municipalities and 60 percent have
Persondosimetri för vårdpersonal, som i sitt yrke exponeras för joniserande strålning, är ständigt ett hett ämne och under konstant utveckling. Stråldosen mäts och registreras för att uppfylla riktlinjer och lagar, som syftar till att hålla personal säkra vid arbete med joniserande strålning. Det finns en rad olika sätt att mäta stråldoser till en människa. För att effektivt uppskatta och mäta strWithin the field of medical radiation protection, radiation safety and personal dosimetry, there is a constant pursuit for improving existing methods and evaluating new approaches for measuring and quantifying the radiation doses that hospital staff may be exposed to in their clinical work. There are numerous ways of determining what doses the staff are being exposed to and the most commonly used
This thesis is based on four projects with the overall aim to investigate vitamin K-dependent protein S functions in relation to its structure. The anticoagulant functions of protein S can be divided in three: 1) cofactor for activated protein C (APC), 2) cofactor for tissue factor pathway inhibitor (TFPI) and 3) APC and TFPI-independent anticoagulant functions. Microparticles might be shed from
Interstitial laser thermotherapy (ILT) is an attractive form of local therapy against cancer because of its anti-tumor immune activity. The aim of this work was to evaluate ILT in breast cancer with respect to technique, changes in tissue immunocompetent cells and effect on prognosis. The method is dependent on accurate assessment of the tumor, and another aim was therefore to evaluate if MRI is b
Syftet med denna studie är att utreda möjligheterna för Öresundskraft AB att utvinna marin förnyelsebar energi från norra Öresund. Studien genomförs i två delar där Öresunds fysikaliska egenskaper samt marina krafttekniker kartläggs i den första för att sedan analysera den möjliga miljöpåverkan från de alternativen som kan vara intressanta i Öresund. De marina energitekniker som studerades var OTEThe purpose of this study is to determine the possibilities for Öresundskraft AB to derive marine renewable energy from northern Öresund, the sound between Sweden and Denmark. The physical properties of the sound, such as temperature, current speed, wave height, salinity gradients, bathymetry, are researched as well as which technologies are present in the current marine renewable energy market. T
Background: Circulating tumor cells (CTCs) carry independent prognostic information in patients with metastatic breast cancer (MBC) on different lines of therapy. Moreover, CTC clusters are suggested to add prognostic information to CTC enumeration alone but their significance is unknown in patients with newly diagnosed MBC. We aimed to evaluate whether longitudinal enumeration of circulating tumo
Objective To date, the major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors and are estimated to control more than 30 candidate miRNAs among night shift workers.Materials and Methods RNA was extracted from plasma samples of 110 night and 90day shift worker
Background: Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear. Objectives: This study sought to compare the effectiveness of lower extremity compression with thigh-high ECS vs sham stockings for the prevention of VVS recurr
Arbetet är utfört åt skogsforskningsstationen Mógilsá som ligger strax norr om Reykjavik. Forskningen inom Mógilsá bedrivs inom delar av eller för hela Island med inriktning inom exempelvis dendrokronologi, proveniensförsök, och studier av insekter. Sedan 1900-talets början har inplantering av exotiska trädarter blivit allt vanligare och i en allt större skala. Syften med inplanteringen är bland aThis study was made in an attempt to give the forest research centre Mógilsá a produced tetratherm map and a better understanding of how topography and temperature influence the growth of two tree species. The digital tetratherm map model, covering the northern part of Iceland, was developed to investigate the correlation between tetratherm and the growth of Picea sitchensis and Larix (sukaczewii
BACKGROUND: Analyses of clinical outcomes following radiotherapy (RT) have advanced our understanding of fundamental radiobiological characteristics in head and neck squamous cell carcinoma (HNSCC). Low fractionation sensitivity appears to be a common feature, as well as susceptibility to changes in overall treatment time (OTT). Large tumors should be harder to cure if a successful RT requires the
